背景:保持足够的水分对最佳健康至关重要,幸福,和性能。那些在压力环境中身体活跃的人,如温暖和/或潮湿的场景,可能特别有脱水的风险,随之而来的是电解质的损失,导致迟缓和身体表现受损。
方法:我们评估了含有L-丙氨酸和L-谷氨酰胺的电解质和氨基酸产品,以及选择维生素[B3(烟酸),B5(泛酸),B6(吡哆醇),B12(钴胺素),和维生素C(抗坏血酸)]。受试者(n=40;四组,n=10)被随机分配服用安慰剂包或安慰剂包,两个,或每天三包测试产品,持续4周,在0、2和4周进行实地考察。我们通过分析血液学参数(全血细胞计数)来测试安全性和耐受性,代谢参数(肝,肾,酸碱平衡),尿液分析最终产品,甲状腺状态[T3(三碘甲状腺原氨酸),T4(甲状腺素),TSH(促甲状腺激素)],耐受性(通过问卷调查),生命体征,和饮食摄入。
结果:统计分析显示了白细胞的十个显着的主要影响(p<0.05),淋巴细胞,中性粒细胞,尿液pH值,甲状腺素,排尿频率,钙,卡路里,脂肪,和胆固醇。观察到MCV的时间和组的相互作用(p<0.05),eGFR,钾,总体耐受性,腹胀,和痉挛-表现为轻度GA紊乱。对于任何结果变量,生理相关性几乎没有变化,无论剂量水平。
结论:我们的结果表明,与安慰剂组相比,该产品在所有剂量水平下都具有良好的耐受性,并且任何测试参数均未发生明显的不良变化。表明在4周治疗期内摄入的相对安全性,在使用的卷中,在物理压力的范围之外。
BACKGROUND: Maintaining adequate hydration is critical to optimal health, well-being, and performance. Those who are physically active in stressful environments, such as warm and/or humid scenarios, may be at particular risk for dehydration with ensuing loss of electrolytes, leading to sluggishness and impaired physical performance.
METHODS: We evaluated an electrolyte and amino acid product containing L-alanine and L-glutamine, as well as select
vitamins [B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B12 (cobalamin), and vitamin C (ascorbic acid)]. Subjects (n = 40; four groups, n = 10) were randomized to consume either a placebo packet or one, two, or three packets daily of the test product for 4 weeks with site visits at 0, 2, and 4 weeks. We tested safety and tolerability by analyzing hematological parameters (complete blood counts), metabolic parameters (hepatic, renal, acid-base balance), urinalysis end products, thyroid status [T3 (triiodothyronine), T4 (thyroxine), TSH (thyroid-stimulating hormone)], tolerability (via questionnaire), vital signs, and dietary intake.
RESULTS: Statistical analyses displayed ten significant main effects (p < 0.05) with white blood cells, lymphocytes, neutrophils, urinary pH, thyroxine, urination frequency, calcium, calories, fat, and cholesterol. Interactions for time and group (p < 0.05) were observed for MCV, eGFR, potassium, overall tolerability, bloating, and cramping-demonstrating mild GA disturbances. Little to no change of physiological relevance was noted for any outcome variable, regardless of dosing level.
CONCLUSIONS: Our results indicate the product was well-tolerated at all dosing levels and no significant adverse changes occurred in any of the test parameters compared to the placebo group, indicating relative safety of ingestion over a 4-week treatment period, at the volumes used, and outside the context of physical stress.