PDF(Pubmed)
Abstract：
BACKGROUND: Maintaining adequate hydration is critical to optimal health, well-being, and performance. Those who are physically active in stressful environments, such as warm and/or humid scenarios, may be at particular risk for dehydration with ensuing loss of electrolytes, leading to sluggishness and impaired physical performance.
METHODS: We evaluated an electrolyte and amino acid product containing L-alanine and L-glutamine, as well as select vitamins [B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B12 (cobalamin), and vitamin C (ascorbic acid)]. Subjects (n = 40; four groups, n = 10) were randomized to consume either a placebo packet or one, two, or three packets daily of the test product for 4 weeks with site visits at 0, 2, and 4 weeks. We tested safety and tolerability by analyzing hematological parameters (complete blood counts), metabolic parameters (hepatic, renal, acid-base balance), urinalysis end products, thyroid status [T3 (triiodothyronine), T4 (thyroxine), TSH (thyroid-stimulating hormone)], tolerability (via questionnaire), vital signs, and dietary intake.
RESULTS: Statistical analyses displayed ten significant main effects (p < 0.05) with white blood cells, lymphocytes, neutrophils, urinary pH, thyroxine, urination frequency, calcium, calories, fat, and cholesterol. Interactions for time and group (p < 0.05) were observed for MCV, eGFR, potassium, overall tolerability, bloating, and cramping-demonstrating mild GA disturbances. Little to no change of physiological relevance was noted for any outcome variable, regardless of dosing level.
CONCLUSIONS: Our results indicate the product was well-tolerated at all dosing levels and no significant adverse changes occurred in any of the test parameters compared to the placebo group, indicating relative safety of ingestion over a 4-week treatment period, at the volumes used, and outside the context of physical stress.
METHODS: We evaluated an electrolyte and amino acid product containing L-alanine and L-glutamine, as well as select vitamins [B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B12 (cobalamin), and vitamin C (ascorbic acid)]. Subjects (n = 40; four groups, n = 10) were randomized to consume either a placebo packet or one, two, or three packets daily of the test product for 4 weeks with site visits at 0, 2, and 4 weeks. We tested safety and tolerability by analyzing hematological parameters (complete blood counts), metabolic parameters (hepatic, renal, acid-base balance), urinalysis end products, thyroid status [T3 (triiodothyronine), T4 (thyroxine), TSH (thyroid-stimulating hormone)], tolerability (via questionnaire), vital signs, and dietary intake.
RESULTS: Statistical analyses displayed ten significant main effects (p < 0.05) with white blood cells, lymphocytes, neutrophils, urinary pH, thyroxine, urination frequency, calcium, calories, fat, and cholesterol. Interactions for time and group (p < 0.05) were observed for MCV, eGFR, potassium, overall tolerability, bloating, and cramping-demonstrating mild GA disturbances. Little to no change of physiological relevance was noted for any outcome variable, regardless of dosing level.
CONCLUSIONS: Our results indicate the product was well-tolerated at all dosing levels and no significant adverse changes occurred in any of the test parameters compared to the placebo group, indicating relative safety of ingestion over a 4-week treatment period, at the volumes used, and outside the context of physical stress.
摘要：
背景：保持足够的水分对最佳健康至关重要，幸福,和性能。那些在压力环境中身体活跃的人，如温暖和/或潮湿的场景，可能特别有脱水的风险，随之而来的是电解质的损失，导致迟缓和身体表现受损。
方法：我们评估了含有L-丙氨酸和L-谷氨酰胺的电解质和氨基酸产品，以及选择维生素[B3（烟酸），B5（泛酸），B6（吡哆醇），B12（钴胺素），和维生素C（抗坏血酸）]。受试者（n=40；四组，n=10）被随机分配服用安慰剂包或安慰剂包，两个,或每天三包测试产品，持续4周，在0、2和4周进行实地考察。我们通过分析血液学参数（全血细胞计数）来测试安全性和耐受性，代谢参数(肝，肾,酸碱平衡)，尿液分析最终产品，甲状腺状态[T3（三碘甲状腺原氨酸），T4（甲状腺素），TSH（促甲状腺激素）]，耐受性（通过问卷调查），生命体征,和饮食摄入。
结果：统计分析显示了白细胞的十个显着的主要影响（p<0.05），淋巴细胞，中性粒细胞，尿液pH值,甲状腺素,排尿频率,钙，卡路里,脂肪，和胆固醇。观察到MCV的时间和组的相互作用（p<0.05），eGFR,钾，总体耐受性，腹胀,和痉挛-表现为轻度GA紊乱。对于任何结果变量，生理相关性几乎没有变化，无论剂量水平。
结论：我们的结果表明，与安慰剂组相比，该产品在所有剂量水平下都具有良好的耐受性，并且任何测试参数均未发生明显的不良变化。表明在4周治疗期内摄入的相对安全性，在使用的卷中，在物理压力的范围之外。
方法：我们评估了含有L-丙氨酸和L-谷氨酰胺的电解质和氨基酸产品，以及选择维生素[B3（烟酸），B5（泛酸），B6（吡哆醇），B12（钴胺素），和维生素C（抗坏血酸）]。受试者（n=40；四组，n=10）被随机分配服用安慰剂包或安慰剂包，两个,或每天三包测试产品，持续4周，在0、2和4周进行实地考察。我们通过分析血液学参数（全血细胞计数）来测试安全性和耐受性，代谢参数(肝，肾,酸碱平衡)，尿液分析最终产品，甲状腺状态[T3（三碘甲状腺原氨酸），T4（甲状腺素），TSH（促甲状腺激素）]，耐受性（通过问卷调查），生命体征,和饮食摄入。
结果：统计分析显示了白细胞的十个显着的主要影响（p<0.05），淋巴细胞，中性粒细胞，尿液pH值,甲状腺素,排尿频率,钙，卡路里,脂肪，和胆固醇。观察到MCV的时间和组的相互作用（p<0.05），eGFR,钾，总体耐受性，腹胀,和痉挛-表现为轻度GA紊乱。对于任何结果变量，生理相关性几乎没有变化，无论剂量水平。
结论：我们的结果表明，与安慰剂组相比，该产品在所有剂量水平下都具有良好的耐受性，并且任何测试参数均未发生明显的不良变化。表明在4周治疗期内摄入的相对安全性，在使用的卷中，在物理压力的范围之外。
