PDF(Pubmed)
Abstract：
Hashimoto\'s thyroiditis (HT) is the leading cause of hypothyroidism, affecting mainly the female population. Many patients with HT have metabolic disorders and nutritional deficiencies. The aim of this study was to evaluate vitamin D, A, E, B2, and B6 concentrations, thyroid function, metabolic profile, and anthropometric parameters of patients with Hashimoto\'s thyroiditis. In 81 female patients with HT (study group), vitamin A and B2 concentrations were significantly lower than in 34 healthy women (control group). No differences were noted in vitamin D, E, and B6 concentrations between groups. Moreover, HT patients had similar anthropometric parameters, lipid profiles, and glucose and insulin concentrations compared to controls. This study showed some relationships between vitamin concentrations and anthropometric or biochemical profiles in HT patients. Among others, in the HT group, the concentration of vitamin D was positively correlated with the level of HDL and negatively correlated with BMI, total fat mass, and insulin level, which influence cardiovascular risk. The results indicate that patients with HT should be routinely tested for vitamin concentrations to prevent nutritional deficiencies. Further studies are also needed on the role of vitamins in the development and progression of HT and the presence of metabolic complications in this population.
摘要：
桥本氏甲状腺炎（HT）是甲状腺功能减退症的主要原因，主要影响女性人口。许多HT患者存在代谢紊乱和营养缺乏。这项研究的目的是评估维生素D，A,E,B2和B6浓度，甲状腺功能,代谢概况，桥本甲状腺炎患者的人体测量参数。在81例女性HT患者（研究组）中，维生素A和B2浓度显著低于34名健康女性(对照组)。维生素D没有差异，E,以及组间的B6浓度。此外，HT患者的人体测量参数相似，脂质分布，与对照组相比，葡萄糖和胰岛素浓度。这项研究显示了HT患者的维生素浓度与人体测量或生化特征之间的一些关系。其中,在HT组中，维生素D浓度与HDL水平呈正相关,与BMI呈负相关,总脂肪量,和胰岛素水平，影响心血管风险。结果表明，应常规测试HT患者的维生素浓度，以防止营养缺乏。还需要进一步研究维生素在HT的发生和发展中的作用以及该人群中代谢并发症的存在。
