PDF(Pubmed)
Abstract：
UNASSIGNED: Though considerable studies suggesting connections between micronutrients and pregnancy complications, current evidence remains inconsistent and lacks causative confirmation. Our study aimed to explore the causal links between them with a two-sample Mendelian randomization (MR) analysis.
UNASSIGNED: Genome-wide association studies (GWAS) data for circulating micronutrients were sourced from GWAS Catalog consortium and PubMed, while data for pregnancy outcomes, including gestational diabetes mellitus (GDM), gestational hypertension (GH), spontaneous abortion (SA), preterm birth (PTB), and stillbirth (SB), were retrieved from the UK Biobank and FinnGen consortia. Causal effects were appraised using inverse variance weighted (IVW), weighted median (WM), and MR-Egger, followed by sensitivity analyses and meta-analysis for validation.
UNASSIGNED: Genetically predicted higher vitamin E (OR = 0.993, 95% CI 0.987-0.998; p = 0.005) levels were inversely associated with SA risk. Consistent results were obtained in meta-analysis (OR = 0.99, 95% CI 0.99-1.00; p = 0.005). Besides, a potential positive causality between genetic predisposition to vitamin B12 and SB was identified in both IVW (OR = 0.974, 95% CI 0.953-0.996; p = 0.018) and WM analysis (OR = 0.965, 95% CI 0.939-0.993; p = 0.013). However, no causal relationships were observed between other analyzed circulating micronutrients and pregnancy complications.
UNASSIGNED: This study offers compelling evidence of causal associations between circulating levels of vitamins E, B12 and the risk of SA and SB, respectively. These findings are pivotal for pregnancy complications screening and prevention, potentially guiding clinical practice and public health policies toward targeted nutritional interventions.
UNASSIGNED: Genome-wide association studies (GWAS) data for circulating micronutrients were sourced from GWAS Catalog consortium and PubMed, while data for pregnancy outcomes, including gestational diabetes mellitus (GDM), gestational hypertension (GH), spontaneous abortion (SA), preterm birth (PTB), and stillbirth (SB), were retrieved from the UK Biobank and FinnGen consortia. Causal effects were appraised using inverse variance weighted (IVW), weighted median (WM), and MR-Egger, followed by sensitivity analyses and meta-analysis for validation.
UNASSIGNED: Genetically predicted higher vitamin E (OR = 0.993, 95% CI 0.987-0.998; p = 0.005) levels were inversely associated with SA risk. Consistent results were obtained in meta-analysis (OR = 0.99, 95% CI 0.99-1.00; p = 0.005). Besides, a potential positive causality between genetic predisposition to vitamin B12 and SB was identified in both IVW (OR = 0.974, 95% CI 0.953-0.996; p = 0.018) and WM analysis (OR = 0.965, 95% CI 0.939-0.993; p = 0.013). However, no causal relationships were observed between other analyzed circulating micronutrients and pregnancy complications.
UNASSIGNED: This study offers compelling evidence of causal associations between circulating levels of vitamins E, B12 and the risk of SA and SB, respectively. These findings are pivotal for pregnancy complications screening and prevention, potentially guiding clinical practice and public health policies toward targeted nutritional interventions.
摘要：
■尽管大量研究表明微量营养素与妊娠并发症之间存在联系，目前的证据仍然不一致，缺乏因果关系的确认。我们的研究旨在通过双样本孟德尔随机化（MR）分析来探索它们之间的因果关系。
■循环微量营养素的全基因组关联研究（GWAS）数据来自GWAS目录联盟和PubMed，而妊娠结局的数据，包括妊娠期糖尿病（GDM），妊娠期高血压(GH),自然流产(SA),早产（PTB），和死产（SB），是从英国生物库和FinnGen财团中检索到的。使用逆方差加权(IVW)评估因果关系，加权中位数(WM)，和MR-Egger,其次是敏感性分析和荟萃分析进行验证。
■遗传预测的较高维生素E水平（OR=0.993，95％CI0.987-0.998；p=0.005）与SA风险呈负相关。在荟萃分析中获得了一致的结果（OR=0.99，95％CI0.99-1.00；p=0.005）。此外,IVW(OR=0.974,95%CI0.953-0.996;p=0.018)和WM分析(OR=0.965,95%CI0.939-0.993;p=0.013)均发现维生素B12遗传易感性与SB之间存在潜在的正因果关系.然而,未观察到其他分析的循环微量营养素与妊娠并发症之间的因果关系.
■这项研究提供了令人信服的证据，证明维生素E的循环水平之间存在因果关系。B12和SA和SB的风险，分别。这些发现对于妊娠并发症的筛查和预防至关重要，潜在的指导临床实践和公共卫生政策对有针对性的营养干预。
■循环微量营养素的全基因组关联研究（GWAS）数据来自GWAS目录联盟和PubMed，而妊娠结局的数据，包括妊娠期糖尿病（GDM），妊娠期高血压(GH),自然流产(SA),早产（PTB），和死产（SB），是从英国生物库和FinnGen财团中检索到的。使用逆方差加权(IVW)评估因果关系，加权中位数(WM)，和MR-Egger,其次是敏感性分析和荟萃分析进行验证。
■遗传预测的较高维生素E水平（OR=0.993，95％CI0.987-0.998；p=0.005）与SA风险呈负相关。在荟萃分析中获得了一致的结果（OR=0.99，95％CI0.99-1.00；p=0.005）。此外,IVW(OR=0.974,95%CI0.953-0.996;p=0.018)和WM分析(OR=0.965,95%CI0.939-0.993;p=0.013)均发现维生素B12遗传易感性与SB之间存在潜在的正因果关系.然而,未观察到其他分析的循环微量营养素与妊娠并发症之间的因果关系.
■这项研究提供了令人信服的证据，证明维生素E的循环水平之间存在因果关系。B12和SA和SB的风险，分别。这些发现对于妊娠并发症的筛查和预防至关重要，潜在的指导临床实践和公共卫生政策对有针对性的营养干预。
