PDF(Pubmed)
Abstract：
UNASSIGNED: To identify the impact of redox imbalance on the clinical evolution of patients with polycystic ovary syndrome and carry out a qualitative and quantitative projection of the benefits of vitamin D supplementation.
UNASSIGNED: Combinations of the keywords polycystic ovary syndrome, vitamin D, oxidative stress, reactive oxygen species, antioxidant, and free radicals were used in PubMed, Cochrane Library, LILACS, EMBASE, and Web of Science databases. The last search was conducted on August 22, 2023.Selection of studies: Based on the inclusion and exclusion criteria, studies were selected considering a low risk of bias, published in the last 5 years in English, which investigated the effects of vitamin D supplementation in women with PCOS, focusing on oxidative stress markers. Of the 136 articles retrieved, 6 intervention studies (445 women) were included.
UNASSIGNED: The risk of bias in included studies was assessed using the Jadad scale, and analysis and visualization of continuous data were performed using Review Manager 5.4.1, summarized as standardized mean differences (SMD) with confidence intervals (CI) of 95%.
UNASSIGNED: Vitamin D effectively reduced malondialdehyde (P=0.002) and total testosterone (P=0.0004) levels and increased total antioxidant capacity levels (P=0.01). Although possible improvements in the modified Ferriman-Gallwey hirsutism score, levels of sex hormone-binding globulin, and free androgen index were identified and the results were not statistically significant.
UNASSIGNED: Vitamin D is a promising alternative for the treatment of PCOS with a positive influence on the oxidative, metabolic, and endocrine disorders of this syndrome.
UNASSIGNED: Combinations of the keywords polycystic ovary syndrome, vitamin D, oxidative stress, reactive oxygen species, antioxidant, and free radicals were used in PubMed, Cochrane Library, LILACS, EMBASE, and Web of Science databases. The last search was conducted on August 22, 2023.Selection of studies: Based on the inclusion and exclusion criteria, studies were selected considering a low risk of bias, published in the last 5 years in English, which investigated the effects of vitamin D supplementation in women with PCOS, focusing on oxidative stress markers. Of the 136 articles retrieved, 6 intervention studies (445 women) were included.
UNASSIGNED: The risk of bias in included studies was assessed using the Jadad scale, and analysis and visualization of continuous data were performed using Review Manager 5.4.1, summarized as standardized mean differences (SMD) with confidence intervals (CI) of 95%.
UNASSIGNED: Vitamin D effectively reduced malondialdehyde (P=0.002) and total testosterone (P=0.0004) levels and increased total antioxidant capacity levels (P=0.01). Although possible improvements in the modified Ferriman-Gallwey hirsutism score, levels of sex hormone-binding globulin, and free androgen index were identified and the results were not statistically significant.
UNASSIGNED: Vitamin D is a promising alternative for the treatment of PCOS with a positive influence on the oxidative, metabolic, and endocrine disorders of this syndrome.
摘要：
■确定氧化还原失衡对多囊卵巢综合征患者临床演变的影响，并对补充维生素D的益处进行定性和定量预测。
■关键词多囊卵巢综合征的组合，维生素D,氧化应激，活性氧，抗氧化剂，在PubMed中使用了自由基，科克伦图书馆,LILACS,EMBASE,和WebofScience数据库。最后一次搜索是在2023年8月22日进行的。选择研究：根据纳入和排除标准，选择研究时考虑到低偏倚风险，在过去的5年中以英文出版，调查了补充维生素D对PCOS女性的影响，专注于氧化应激标志物。在检索到的136篇文章中，纳入6项干预研究（445名女性）。
■使用Jadad量表评估纳入研究的偏倚风险，使用ReviewManager5.4.1对连续数据进行分析和可视化,总结为标准化均数差异(SMD),置信区间(CI)为95%.
■维生素D可有效降低丙二醛（P=0.002）和总睾酮（P=0.0004）水平，并增加总抗氧化能力水平（P=0.01）。尽管改良的Ferriman-Gallwey多毛症评分可能有所改善，性激素结合球蛋白的水平，和游离雄激素指数进行鉴定，结果无统计学意义。
■维生素D是治疗PCOS的有希望的替代品，对氧化有积极的影响，新陈代谢，和内分泌失调的这种综合征。
■关键词多囊卵巢综合征的组合，维生素D,氧化应激，活性氧，抗氧化剂，在PubMed中使用了自由基，科克伦图书馆,LILACS,EMBASE,和WebofScience数据库。最后一次搜索是在2023年8月22日进行的。选择研究：根据纳入和排除标准，选择研究时考虑到低偏倚风险，在过去的5年中以英文出版，调查了补充维生素D对PCOS女性的影响，专注于氧化应激标志物。在检索到的136篇文章中，纳入6项干预研究（445名女性）。
■使用Jadad量表评估纳入研究的偏倚风险，使用ReviewManager5.4.1对连续数据进行分析和可视化,总结为标准化均数差异(SMD),置信区间(CI)为95%.
■维生素D可有效降低丙二醛（P=0.002）和总睾酮（P=0.0004）水平，并增加总抗氧化能力水平（P=0.01）。尽管改良的Ferriman-Gallwey多毛症评分可能有所改善，性激素结合球蛋白的水平，和游离雄激素指数进行鉴定，结果无统计学意义。
■维生素D是治疗PCOS的有希望的替代品，对氧化有积极的影响，新陈代谢，和内分泌失调的这种综合征。
