PDF(Pubmed)
Abstract：
OBJECTIVE: Oxidative stress is strongly associated with atopic dermatitis (AD), and increased antioxidant intake could potentially reduce the risk of or alleviate its symptoms. However, the argument is disputed. Therefore, we conducted a Mendelian randomization (MR) analysis to explore the causal relationship between dietary antioxidant vitamin intake and AD.
METHODS: We applied MR analysis to examine the causative association between dietary antioxidant vitamin intake (vitamin C, vitamin E, carotene, and retinol) and AD. The genome-wide association study (GWAS) summary data for antioxidant vitamins intake and AD were obtained from the IEU OpenGWAS database and the UK biobank. Our study consisted of two major parts, MR analysis to detect the causal relationship between exposure and outcome, and sensitivity analysis as supplemental evidence to verify the robustness of the results.
RESULTS: The results revealed a suggestive causal relationship between vitamin E intake and AD (p = 0.038, OR 95% CI = 0.745-0.992). However, there was no causal relationship between the other three vitamins (vitamin C, carotene, and retinol) and AD (p = 0.507, OR 95% CI = 0.826-1.099) (p = 0.890, OR 95% CI = 0.864-1.184) (p = 0.492, OR 95% CI = 0.893-1.264). None of the single nucleotide polymorphisms (SNPs) were detected as heterogeneous and pleiotropy in the sensitivity analysis (p > 0.05).
CONCLUSIONS: The analysis suggested that dietary intake of vitamin E may potentially lower the risk of AD. Conversely, intake of vitamin C, retinol, and carotene is not causally related to AD. Although vitamin E intake could be protective against AD, intake of dietary antioxidant vitamins to prevent or treat AD is not necessary.
METHODS: We applied MR analysis to examine the causative association between dietary antioxidant vitamin intake (vitamin C, vitamin E, carotene, and retinol) and AD. The genome-wide association study (GWAS) summary data for antioxidant vitamins intake and AD were obtained from the IEU OpenGWAS database and the UK biobank. Our study consisted of two major parts, MR analysis to detect the causal relationship between exposure and outcome, and sensitivity analysis as supplemental evidence to verify the robustness of the results.
RESULTS: The results revealed a suggestive causal relationship between vitamin E intake and AD (p = 0.038, OR 95% CI = 0.745-0.992). However, there was no causal relationship between the other three vitamins (vitamin C, carotene, and retinol) and AD (p = 0.507, OR 95% CI = 0.826-1.099) (p = 0.890, OR 95% CI = 0.864-1.184) (p = 0.492, OR 95% CI = 0.893-1.264). None of the single nucleotide polymorphisms (SNPs) were detected as heterogeneous and pleiotropy in the sensitivity analysis (p > 0.05).
CONCLUSIONS: The analysis suggested that dietary intake of vitamin E may potentially lower the risk of AD. Conversely, intake of vitamin C, retinol, and carotene is not causally related to AD. Although vitamin E intake could be protective against AD, intake of dietary antioxidant vitamins to prevent or treat AD is not necessary.
摘要：
目的：氧化应激与特应性皮炎（AD）密切相关，增加抗氧化剂的摄入量可能会降低其症状的风险或减轻其症状。然而,这个论点是有争议的。因此,我们进行了孟德尔随机化(MR)分析,以探讨膳食抗氧化剂维生素摄入量与AD之间的因果关系.
方法：我们应用MR分析来检查膳食抗氧化剂维生素摄入量（维生素C，维生素E,胡萝卜素,和视黄醇）和AD。抗氧化维生素摄入和AD的全基因组关联研究（GWAS）汇总数据来自IEUOpenGWAS数据库和英国生物库。我们的研究由两大部分组成,MR分析以检测暴露与结果之间的因果关系，和敏感性分析作为补充证据，验证结果的稳健性。
结果：结果显示维生素E摄入量与AD之间存在因果关系（p=0.038，OR95％CI=0.745-0.992）。然而,其他三种维生素（维生素C，胡萝卜素,和视黄醇）和AD（p=0.507，OR95％CI=0.826-1.099）（p=0.890，OR95％CI=0.864-1.184）（p=0.492，OR95％CI=0.893-1.264）。在敏感性分析中，没有发现单核苷酸多态性（SNP）具有异质性和多效性（p>0.05）。
结论：分析表明，饮食中摄入维生素E可能会降低AD的风险。相反，摄入维生素C，视黄醇,胡萝卜素与AD无因果关系。虽然摄入维生素E可以预防AD，摄入膳食抗氧化维生素来预防或治疗AD是不必要的。
方法：我们应用MR分析来检查膳食抗氧化剂维生素摄入量（维生素C，维生素E,胡萝卜素,和视黄醇）和AD。抗氧化维生素摄入和AD的全基因组关联研究（GWAS）汇总数据来自IEUOpenGWAS数据库和英国生物库。我们的研究由两大部分组成,MR分析以检测暴露与结果之间的因果关系，和敏感性分析作为补充证据，验证结果的稳健性。
结果：结果显示维生素E摄入量与AD之间存在因果关系（p=0.038，OR95％CI=0.745-0.992）。然而,其他三种维生素（维生素C，胡萝卜素,和视黄醇）和AD（p=0.507，OR95％CI=0.826-1.099）（p=0.890，OR95％CI=0.864-1.184）（p=0.492，OR95％CI=0.893-1.264）。在敏感性分析中，没有发现单核苷酸多态性（SNP）具有异质性和多效性（p>0.05）。
结论：分析表明，饮食中摄入维生素E可能会降低AD的风险。相反，摄入维生素C，视黄醇,胡萝卜素与AD无因果关系。虽然摄入维生素E可以预防AD，摄入膳食抗氧化维生素来预防或治疗AD是不必要的。
