目的:探讨健康年轻人的尼古丁摄入是否引起脉络膜厚度的差异,特别是比较尼古丁口香糖对电子烟(vaping)的影响,同时保持一致的4毫克尼古丁剂量。
方法:在一项随机双盲前瞻性横断面研究中,20名健康参与者(平均年龄±标准差:23±2.36岁)被随机分配到尼古丁口香糖或vaping组。脉络膜厚度(ChT)测量使用光学相干断层扫描(OCT)(Topcon3DOCT-1Maestro系统)在基线,摄入4毫克尼古丁后30分钟和60分钟,从五个不同的水平区域进行ChT测量。
结果:尼古丁输送方法(口香糖或vaping)均未显示对基线时五个测量区域中受试者的ChT平均得分有统计学意义的影响,30和60分钟(p>0.05)。然而,在五个区域的受试者中观察到ChT平均得分存在显着差异(F(1.83,72)=36.43,p<0.001),不管其他研究因素,如群体,时间,和访视(p>0.05)。当按吸烟类型(烟草,vaping,和双重)(p=0.003)。
结论:这项研究的结果表明,尼古丁,高达4毫克的特定浓度,对脉络膜厚度没有统计学上显著的血管收缩作用,无论交付方式如何,在被检查的小组内。这些发现为年轻人的尼古丁摄入量与脉络膜动力学之间的关系提供了有价值的见解。
OBJECTIVE: To explore whether differences in choroidal thickness arise from nicotine consumption in healthy young individuals, specifically comparing the effects of nicotine gum to electronic cigarette (vaping), while maintaining a consistent 4 mg nicotine dosage.
METHODS: In a randomized double-blinded prospective cross-sectional
study, 20 healthy participants (mean age ± standard deviation: 23 ± 2.36 years) were randomly assigned to either the nicotine gum or vaping group. Choroidal thickness (ChT) measurements were conducted using optical coherence tomography (OCT) (Topcon 3D OCT-1 Maestro System) at baseline, 30, and 60 min after ingesting 4 mg of nicotine, with ChT measurements taken from five different horizontal areas.
RESULTS: Neither the nicotine delivery method (gum or vaping) demonstrated a statistically significant impact on ChT mean scores among subjects in the five measured areas at baseline, 30, and 60 min (p > 0.05). However, significant differences were observed in ChT mean scores within subjects across the five areas (F (1.83, 72) = 36.43, p < 0.001), regardless of other
study factors such as group, time, and visit (p > 0.05). A statistically significant interaction was identified between the factors of area and time concerning participants\' ChT mean scores when stratified by the type of smoking (tobacco, vaping, and dual) (p = 0.003).
CONCLUSIONS: The results of this
study revealed that nicotine, up to particular concentration of 4 mg, does not have a statistically significant vasoconstrictive effect on choroidal thickness, regardless of the delivery method, within the examined group. These findings offer valuable insights into the relationship between nicotine intake and choroidal dynamics in young adults.