Abstract：
OBJECTIVE: The purpose of this study is to compare choroidal thickness in juvenile open angle glaucoma (JOAG) and healthy controls using spectral domain optical coherence tomography (SD-OCT) and study its correlations.
METHODS: In this case-control study, 56 eyes of 28 JOAG patients and an equal number of controls were recruited. SD-OCT was used to measure the choroidal thickness (ChT), in the macular region at 5 locations: subfoveal, 1500 µm and 3000 µm nasal and temporal to the foveal center, and in the peripapillary region at 6 locations: up to 1500 µm, nasal and temporal to the disc, respectively. The ChT and its correlations with age, intraocular pressure, cup-to-disc ratio, central corneal thickness, mean deviation, and axial length were studied.
RESULTS: The average macular ChT in JOAG was 306.30 ± 56.49 µm vs. 277.12 ± 64.68 µm in controls. The average peripapillary ChT in JOAG was 197.79 ± 44.05 µm vs. 187.24 ± 38.89 µm in controls. The average total ChT (p = 0.042), the average macular ChT (p = 0.022), the subfoveal ChT (p = 0.022), the ChT 1500 µm (p < 0.001), and 3000 µm temporal to the fovea (p = 0.002) were significantly thicker in the JOAG group. In the JOAG group, the average macular ChT had a significant negative correlation with age, whereas axial length was positively correlated with the average peripapillary ChT.
CONCLUSIONS: In this South Asian cohort of JOAG, the average total ChT, average macular ChT, subfoveal ChT, and ChT at 1500 µm, and 3000 µm temporal to the fovea were significantly thicker when compared to healthy controls.
METHODS: In this case-control study, 56 eyes of 28 JOAG patients and an equal number of controls were recruited. SD-OCT was used to measure the choroidal thickness (ChT), in the macular region at 5 locations: subfoveal, 1500 µm and 3000 µm nasal and temporal to the foveal center, and in the peripapillary region at 6 locations: up to 1500 µm, nasal and temporal to the disc, respectively. The ChT and its correlations with age, intraocular pressure, cup-to-disc ratio, central corneal thickness, mean deviation, and axial length were studied.
RESULTS: The average macular ChT in JOAG was 306.30 ± 56.49 µm vs. 277.12 ± 64.68 µm in controls. The average peripapillary ChT in JOAG was 197.79 ± 44.05 µm vs. 187.24 ± 38.89 µm in controls. The average total ChT (p = 0.042), the average macular ChT (p = 0.022), the subfoveal ChT (p = 0.022), the ChT 1500 µm (p < 0.001), and 3000 µm temporal to the fovea (p = 0.002) were significantly thicker in the JOAG group. In the JOAG group, the average macular ChT had a significant negative correlation with age, whereas axial length was positively correlated with the average peripapillary ChT.
CONCLUSIONS: In this South Asian cohort of JOAG, the average total ChT, average macular ChT, subfoveal ChT, and ChT at 1500 µm, and 3000 µm temporal to the fovea were significantly thicker when compared to healthy controls.
摘要：
目的：本研究的目的是使用谱域光学相干断层扫描（SD-OCT）比较青少年开角型青光眼（JOAG）和健康对照中的脉络膜厚度，并研究其相关性。
方法：在本病例对照研究中，招募了28名JOAG患者的56只眼和相同数量的对照。SD-OCT用于测量脉络膜厚度（ChT），在黄斑区的5个位置:中心凹下，1500µm和3000µm鼻腔和颞部到中央凹中心，在6个位置的乳头周围区域：高达1500µm，鼻部和颞部到椎间盘，分别。ChT及其与年龄的相关性，眼内压,杯盘比，中央角膜厚度,平均偏差，和轴向长度进行了研究。
结果：JOAG的平均黄斑ChT为306.30±56.49µm，与对照组为277.12±64.68µm。JOAG的平均乳头周围ChT为197.79±44.05µm，而不是对照组为187.24±38.89µm。平均总ChT（p=0.042），平均黄斑ChT（p=0.022），中央凹ChT（p=0.022），ChT1500µm（p<0.001），在JOAG组中，距中央凹的3000µm（p=0.002）明显更厚。在JOAG小组中，平均黄斑ChT与年龄呈显著负相关,而眼轴长度与平均乳头周围ChT呈正相关。
结论：在JAAG的这个南亚队列中，平均总ChT，平均黄斑ChT，中央凹ChT,和1500µm的ChT，与健康对照组相比，距中央凹3000µm的时间厚度明显更厚。
方法：在本病例对照研究中，招募了28名JOAG患者的56只眼和相同数量的对照。SD-OCT用于测量脉络膜厚度（ChT），在黄斑区的5个位置:中心凹下，1500µm和3000µm鼻腔和颞部到中央凹中心，在6个位置的乳头周围区域：高达1500µm，鼻部和颞部到椎间盘，分别。ChT及其与年龄的相关性，眼内压,杯盘比，中央角膜厚度,平均偏差，和轴向长度进行了研究。
结果：JOAG的平均黄斑ChT为306.30±56.49µm，与对照组为277.12±64.68µm。JOAG的平均乳头周围ChT为197.79±44.05µm，而不是对照组为187.24±38.89µm。平均总ChT（p=0.042），平均黄斑ChT（p=0.022），中央凹ChT（p=0.022），ChT1500µm（p<0.001），在JOAG组中，距中央凹的3000µm（p=0.002）明显更厚。在JOAG小组中，平均黄斑ChT与年龄呈显著负相关,而眼轴长度与平均乳头周围ChT呈正相关。
结论：在JAAG的这个南亚队列中，平均总ChT，平均黄斑ChT，中央凹ChT,和1500µm的ChT，与健康对照组相比，距中央凹3000µm的时间厚度明显更厚。
