PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to evaluate choroidal thickness (CT) in patients with rheumatoid arthritis (RA) and healthy controls and to determine its relationship with RA-associated interstitial lung disease (RA-ILD).
UNASSIGNED: A total of 63 patients with RA and 36 age- and sex-matched healthy controls were recruited in the cross-sectional study. Serological findings, Disease Activity Score-28, disease duration, and medical treatment of patients were recorded. Patients with RA were subdivided into two groups: patients with RA-ILD (Group 1) and patients with RA but without ILD (RA-noILD; Group 2). CTs were measured using enhanced depth imaging optical coherence tomography. CT was measured at five points: the subfoveal region, 750 μm nasal and temporal to the fovea, 1500 μm nasal and temporal to the fovea. Patients with RA-ILD were evaluated with delta high-resolution computed tomography (ΔHRCT) and pulmonary function test to determine the severity of interstitial lung disease.
UNASSIGNED: Four of 63 RA patients were excluded due to comorbidities. Thus, 59 RA patients, 20 in the RA-ILD group and 39 in the RA-noILD group, were included in the analyses. The RA groups were similar in terms of clinical characteristics and laboratory findings. There were statistically significant differences between Group 1, Group 2 and healthy controls (Group 3) compared to all CT values (p<0.05). The mean CT measured at 750 μm and 1500 μm nasal to the fovea was lowest in the RA-ILD group, followed by the RA-noILD and healthy groups (p<0.05). CT measurements did not correlate with the pulmonary function test and ΔHRCT.
UNASSIGNED: RA-ILD patients had a thinner CT measured at nasal points. However, there was no association between CT measurements and the severity of ILD.
UNASSIGNED: A total of 63 patients with RA and 36 age- and sex-matched healthy controls were recruited in the cross-sectional study. Serological findings, Disease Activity Score-28, disease duration, and medical treatment of patients were recorded. Patients with RA were subdivided into two groups: patients with RA-ILD (Group 1) and patients with RA but without ILD (RA-noILD; Group 2). CTs were measured using enhanced depth imaging optical coherence tomography. CT was measured at five points: the subfoveal region, 750 μm nasal and temporal to the fovea, 1500 μm nasal and temporal to the fovea. Patients with RA-ILD were evaluated with delta high-resolution computed tomography (ΔHRCT) and pulmonary function test to determine the severity of interstitial lung disease.
UNASSIGNED: Four of 63 RA patients were excluded due to comorbidities. Thus, 59 RA patients, 20 in the RA-ILD group and 39 in the RA-noILD group, were included in the analyses. The RA groups were similar in terms of clinical characteristics and laboratory findings. There were statistically significant differences between Group 1, Group 2 and healthy controls (Group 3) compared to all CT values (p<0.05). The mean CT measured at 750 μm and 1500 μm nasal to the fovea was lowest in the RA-ILD group, followed by the RA-noILD and healthy groups (p<0.05). CT measurements did not correlate with the pulmonary function test and ΔHRCT.
UNASSIGNED: RA-ILD patients had a thinner CT measured at nasal points. However, there was no association between CT measurements and the severity of ILD.
摘要：
■本研究旨在评估类风湿关节炎（RA）患者和健康对照者的脉络膜厚度（CT），并确定其与RA相关的间质性肺病（RA-ILD）的关系。
■本横断面研究共招募了63名RA患者和36名年龄和性别匹配的健康对照。血清学发现,疾病活动评分-28，疾病持续时间，并记录患者的医疗情况。RA患者分为两组：RA-ILD患者（第1组）和RA但无ILD患者（RA-noILD；第2组）。使用增强深度成像光学相干断层扫描测量CT。在五个点测量CT：中心凹下区域，750μm鼻和颞部到中央凹，1500μm鼻和颞到中央凹。使用δ高分辨率计算机断层扫描（ΔHRCT）和肺功能测试评估RA-ILD患者，以确定间质性肺病的严重程度。
■63例RA患者中有4例因合并症被排除。因此，59例RA患者，RA-ILD组20例，RA-noILD组39例，包括在分析中。RA组在临床特征和实验室检查结果方面相似。与所有CT值相比,组1、组2和健康对照(组3)之间存在统计学显著差异(p<0.05)。在RA-ILD组中，在距中央凹750μm和1500μm处测量的平均CT最低，其次是RA-noILD和健康组（p<0.05）。CT测量与肺功能测试和ΔHRCT无关。
■RA-ILD患者的鼻部CT较细。然而,CT测量值与ILD的严重程度无相关性.
■本横断面研究共招募了63名RA患者和36名年龄和性别匹配的健康对照。血清学发现,疾病活动评分-28，疾病持续时间，并记录患者的医疗情况。RA患者分为两组：RA-ILD患者（第1组）和RA但无ILD患者（RA-noILD；第2组）。使用增强深度成像光学相干断层扫描测量CT。在五个点测量CT：中心凹下区域，750μm鼻和颞部到中央凹，1500μm鼻和颞到中央凹。使用δ高分辨率计算机断层扫描（ΔHRCT）和肺功能测试评估RA-ILD患者，以确定间质性肺病的严重程度。
■63例RA患者中有4例因合并症被排除。因此，59例RA患者，RA-ILD组20例，RA-noILD组39例，包括在分析中。RA组在临床特征和实验室检查结果方面相似。与所有CT值相比,组1、组2和健康对照(组3)之间存在统计学显著差异(p<0.05)。在RA-ILD组中，在距中央凹750μm和1500μm处测量的平均CT最低，其次是RA-noILD和健康组（p<0.05）。CT测量与肺功能测试和ΔHRCT无关。
■RA-ILD患者的鼻部CT较细。然而,CT测量值与ILD的严重程度无相关性.
