Biomimetics

仿生学
  • 文章类型: Journal Article
    土壤接合组分在农业生产和工程建设中起着至关重要的作用。然而,直接与土壤相互作用的土壤接合组分经常遭受高阻力的问题,附着力,和穿,这大大降低了土壤操作的效率和质量。在广泛运用仿生学原理的同时,对土壤接合构件的设计进行了大量的特色研究,取得了显著的研究成果。这篇综述对仿生在土壤接合组件设计中的应用进行了全面的文献调查。重点是在以下三个方面的性能优化:减少吃水,防粘连,和耐磨性。系统地解释了各种仿生土壤接合成分的机理。在文献分析和仿生研究的基础上,从机理和应用角度讨论了仿生土壤参与成分的未来发展趋势。这项研究有望为解决相关的科学和工程挑战提供新的见解和灵感。
    Soil-engaging components play a critical role in agricultural production and engineering construction. However, the soil-engaging components directly interacting with the soil often suffer from the problems of high resistance, adhesion, and wear, which significantly reduce the efficiency and quality of soil operations. A large number of featured studies on the design of soil-engaging components have been carried out while applying the principles of bionics extensively, and significant research results have been achieved. This review conducts a comprehensive literature survey on the application of biomimetics in the design of soil-engaging components. The focus is on performance optimization in regard to the following three aspects: draught reduction, anti-adhesion, and wear resistance. The mechanisms of various biomimetic soil-engaging components are systematically explained. Based on the literature analysis and biomimetic research, future trends in the development of biomimetic soil-engaging components are discussed from both the mechanism and application perspectives. This research is expected to provide new insights and inspiration for addressing related scientific and engineering challenges.
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  • 文章类型: Systematic Review
    这项研究基于对考虑节肢动物解剖结构的硬质移动机器人机电系统的生物启发设计的文献计量分析,进行了为期10年的系统综述。这些是最多样化的一组动物,其灵活的生物力学和适应的形态,因此,它可以激发机器人的发展。论文从两个国际数据库(Scopus和WebofScience)和一个平台(航空航天研究中心)进行了审查,然后将它们分类为:出版年份(2013年1月至2023年4月),节肢动物群,出版期刊,会议记录,编辑出版商,研究团队,机器人按节肢动物的名称分类,肢体的运动支撑,腿/臂的数量,腿/身体段的数量,肢体的自由度,机械驱动类型,模块化系统,和环境适应。在筛选过程中,分析了33000多件作品。最后,总共174项研究(90项期刊类型,84会议型)被选中进行深入研究:昆虫纲-六足动物(53.8%),蜘蛛-章鱼(20.7%),甲壳类动物-足类(16,1%),和Myriapoda-cent和千足虫(9,2%)。该研究显示,最活跃的社论是电气和电子工程师协会,Springer,MDPI,和Elsevier,虽然最有影响力的研究人员位于美国,中国,新加坡,和日本。大多数作品都与蜘蛛有关,螃蟹,毛毛虫,蟑螂,和cent。我们得出的结论是“关节病”研究,它融合了节肢动物和机器人,不断增长,包括大量相关研究,这些研究发现可以激发设计生物机电系统的新方法。
    This research presents a 10-year systematic review based on bibliometric analysis of the bio-inspired design of hard-bodied mobile robot mechatronic systems considering the anatomy of arthropods. These are the most diverse group of animals whose flexible biomechanics and adaptable morphology, thus, it can inspire robot development. Papers were reviewed from two international databases (Scopus and Web of Science) and one platform (Aerospace Research Central), then they were classified according to: Year of publication (January 2013 to April 2023), arthropod group, published journal, conference proceedings, editorial publisher, research teams, robot classification according to the name of arthropod, limb\'s locomotion support, number of legs/arms, number of legs/body segments, limb\'s degrees of freedom, mechanical actuation type, modular system, and environment adaptation. During the screening, more than 33 000 works were analyzed. Finally, a total of 174 studies (90 journal-type, 84 conference-type) were selected for in-depth study: Insecta-hexapods (53.8%), Arachnida-octopods (20.7%), Crustacea-decapods (16.1%), and Myriapoda-centipedes and millipedes (9.2%). The study reveals that the most active editorials are the Institute of Electrical and Electronics Engineers Inc., Springer, MDPI, and Elsevier, while the most influential researchers are located in the USA, China, Singapore, and Japan. Most works pertained to spiders, crabs, caterpillars, cockroaches, and centipedes. We conclude that \'arthrobotics\' research, which merges arthropods and robotics, is constantly growing and includes a high number of relevant studies with findings that can inspire new methods to design biomechatronic systems.
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  • 文章类型: Journal Article
    摩擦力,磨损,随之而来的能量耗散在具有移动组件的系统中构成了重大挑战,跨越各个领域,包括纳米机电系统(NEMS/MEMS)和生物MEMS(微型机器人),髋关节假体(生物材料),海上风力和水力涡轮机,太空飞行器,用于光伏的太阳能镜,摩擦发电机,等。自然启发的仿生表面提供了有效的纹理策略的有价值的例子,涵盖各种几何和拓扑方法,以减轻各种场景中的摩擦效应和相关功能。通过采用仿生表面修饰,例如,粗糙度剪裁,可以产生系统的多功能性,以有效地减少摩擦和磨损,提高承载能力,提高在不同环境中的自我适应能力,改善化学相互作用,促进生物相互作用,等。然而,由于对摩擦学/生物摩擦学环境中功能方面的机械理解有限,因此生物启发纹理的全部潜力仍未开发。当前的评论扩展到表面工程,并提供了生物启发的纹理的全面和关键的评估,表现出摩擦学和生物学之间的可持续协同作用。全面讨论了从自然界中成功发展的表面/摩擦学解决方案的例子,这些解决方案可以有效解决干燥和润滑接触情况下的复杂摩擦学问题。审查包括四个主要的磨损条件:滑动,固体颗粒侵蚀,加工或切割,和冲击(能量吸收)。此外,它探讨了地形及其设计参数如何在指定的摩擦学条件下提供定制的响应(多功能)。此外,提出了具有增强耐磨性的生物启发材料和结构的未来潜力的跨学科观点。
    Friction, wear, and the consequent energy dissipation pose significant challenges in systems with moving components, spanning various domains, including nanoelectromechanical systems (NEMS/MEMS) and bio-MEMS (microrobots), hip prostheses (biomaterials), offshore wind and hydro turbines, space vehicles, solar mirrors for photovoltaics, triboelectric generators, etc. Nature-inspired bionic surfaces offer valuable examples of effective texturing strategies, encompassing various geometric and topological approaches tailored to mitigate frictional effects and related functionalities in various scenarios. By employing biomimetic surface modifications, for example, roughness tailoring, multifunctionality of the system can be generated to efficiently reduce friction and wear, enhance load-bearing capacity, improve self-adaptiveness in different environments, improve chemical interactions, facilitate biological interactions, etc. However, the full potential of bioinspired texturing remains untapped due to the limited mechanistic understanding of functional aspects in tribological/biotribological settings. The current review extends to surface engineering and provides a comprehensive and critical assessment of bioinspired texturing that exhibits sustainable synergy between tribology and biology. The successful evolving examples from nature for surface/tribological solutions that can efficiently solve complex tribological problems in both dry and lubricated contact situations are comprehensively discussed. The review encompasses four major wear conditions: sliding, solid-particle erosion, machining or cutting, and impact (energy absorbing). Furthermore, it explores how topographies and their design parameters can provide tailored responses (multifunctionality) under specified tribological conditions. Additionally, an interdisciplinary perspective on the future potential of bioinspired materials and structures with enhanced wear resistance is presented.
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  • 文章类型: Journal Article
    Nanotheranosics,尤其是那些采用仿生方法的人,对分子成像和癌症治疗具有重要意义。诊断和治疗的结合,被称为癌症治疗药,代表了现代肿瘤学的一个有前途的策略。仿生学,受到大自然的启发,提供了一个有潜力推进癌症治疗的多学科途径。这篇综述全面分析了基于仿生药物的癌症疗法的最新进展,强调其在克服当前治疗挑战中的作用,专注于乳房,前列腺,和皮肤癌。已经探索了仿生方法来解决多药耐药性(MDR),强调它们在免疫治疗和光热治疗中的作用。涵盖的具体领域包括绕过MDR机制的仿生药物递送系统,免疫检查点封锁的仿生平台,免疫细胞调节,和光热肿瘤消融。讨论了增强放射治疗剂吸收的目标技术,以及对全球nantheranosics临床试验的全面审查。这篇综述深入研究了仿生材料,纳米技术,和生物启发的癌症成像策略,诊断,和靶向药物递送。这些包括成像探头,造影剂,和生物传感器用于增强特异性和灵敏度。靶向药物递送的仿生策略涉及纳米颗粒的设计,脂质体,和水凝胶用于位点特异性递送和改善的治疗功效。总的来说,当前的审查为调查人员提供了宝贵的信息,临床医生,生物医学工程师,提供最新的仿生药物在癌症治疗中的应用的见解。利用仿生学旨在彻底改变癌症诊断,治疗,和患者结果。
    Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers. Biomimetic approaches have been explored to address multidrug resistance (MDR), emphasizing their role in immunotherapy and photothermal therapy. The specific areas covered include biomimetic drug delivery systems bypassing MDR mechanisms, biomimetic platforms for immune checkpoint blockade, immune cell modulation, and photothermal tumor ablation. Pretargeting techniques enhancing radiotherapeutic agent uptake are discussed, along with a comprehensive review of clinical trials of global nanotheranostics. This review delves into biomimetic materials, nanotechnology, and bioinspired strategies for cancer imaging, diagnosis, and targeted drug delivery. These include imaging probes, contrast agents, and biosensors for enhanced specificity and sensitivity. Biomimetic strategies for targeted drug delivery involve the design of nanoparticles, liposomes, and hydrogels for site-specific delivery and improved therapeutic efficacy. Overall, this current review provides valuable information for investigators, clinicians, and biomedical engineers, offering insights into the latest biomimetics applications in cancer theranostics. Leveraging biomimetics aims to revolutionize cancer diagnosis, treatment, and patient outcomes.
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  • 文章类型: Journal Article
    在过去的几年里,研究界目睹了对仿生学的兴趣,特别是在海洋领域。由于恶劣的海洋环境所带来的困难,刺激了仿生研究作为许多商业和基于研究的海洋企业的革命性补救措施。仿生海洋机器人通过模仿海洋生物的各种结构和行为,并利用这些海洋生物数千年来发展的进化优势和适应性,在恶劣的条件下茁壮成长,从而处于这项创新的最前沿。这项全面的研究探讨了基于其推进机制的仿生海洋机器人的当前发展和研究工作。通过检查这些仿生设计,该审查旨在解决埋在自然界中的谜团,并为海洋改善提供重要信息。除了阐明这些生物启发机制的复杂性之外,调查有助于指导未来的研究方向和可能的障碍,推动仿生海洋机器人技术领域的进一步发展。考虑到利用自然的创造力在地球上最具挑战性的环境之一中导航和茁壮成长的革命性潜力,当前审查的结论敦促通过整合机器人和生物学的多学科方法。仿生海洋机器人领域不仅代表了我们与海洋关系的范式转变,但通过理解和模仿自然的解决方案,它也为可持续勘探和利用海洋资源开辟了以前难以想象的可能性。
    Over the past few years, the research community has witnessed a burgeoning interest in biomimetics, particularly within the marine sector. The study of biomimicry as a revolutionary remedy for numerous commercial and research-based marine businesses has been spurred by the difficulties presented by the harsh maritime environment. Biomimetic marine robots are at the forefront of this innovation by imitating various structures and behaviors of marine life and utilizing the evolutionary advantages and adaptations these marine organisms have developed over millennia to thrive in harsh conditions. This thorough examination explores current developments and research efforts in biomimetic marine robots based on their propulsion mechanisms. By examining these biomimetic designs, the review aims to solve the mysteries buried in the natural world and provide vital information for marine improvements. In addition to illuminating the complexities of these bio-inspired mechanisms, the investigation helps to steer future research directions and possible obstacles, spurring additional advancements in the field of biomimetic marine robotics. Considering the revolutionary potential of using nature\'s inventiveness to navigate and thrive in one of the most challenging environments on Earth, the current review\'s conclusion urges a multidisciplinary approach by integrating robotics and biology. The field of biomimetic marine robotics not only represents a paradigm shift in our relationship with the oceans, but it also opens previously unimaginable possibilities for sustainable exploration and use of marine resources by understanding and imitating nature\'s solutions.
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  • 文章类型: Journal Article
    骨转移主要发生在乳腺,前列腺,或肺癌将肿瘤细胞传播到骨组织中,导致一系列骨骼组织并发症,在严重的情况下,脊髓压迫导致的瘫痪。不幸的是,我们对病理生理机制的理解不完整,骨转移研究进入临床的过程缓慢,主要是由于缺乏可靠的离体和体内模型来研究疾病进展。非常需要开发可靠和合理的模型来研究肿瘤细胞如何成为循环细胞,然后侵入并依次定植于骨骼。组织工程技术的进步提供了可靠的3D组织替代方案,这些方案回答了相关的研究问题,以了解癌症的演变和转移进展的关键功能特性以及治疗方法的预后。在这里,我们对涉及骨转移的细胞机制进行了概述,包括对正常骨生理学以及转移开始和进展的简短总结。此外,我们全面总结了基于最先进的印刷技术制造可靠骨肿瘤模型的最新进展和方法,这些技术概括了天然组织的结构和生物学特征。重要声明:这篇综述提供了与用于研究特定骨转移疾病的各种印刷骨转移模型相关的集体发现的全面总结。相关特征功能及化疗药物筛选。对这些肿瘤模型进行综合评价和比较,就其重现生理转移微环境的能力而言。本文讨论了各种生物材料(天然和合成聚合物以及基于陶瓷的基材)以及用于3D骨转移模型打印的模型的打印策略和设计体系结构。这篇综述通过关注这些技术在化疗药物筛选中的临床应用所需的视角模型,清楚地揭示了3D打印技术在骨转移研究中的当前挑战和前景。
    Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, in severe cases, paralysis resulting from spinal cord compression. Unfortunately, our understanding of pathophysiological mechanisms is incomplete and the translation of bone metastasis research into the clinic has been slow, mainly due to the lack of credible ex vivo and in vivo models to study the disease progression. Development of reliable and rational models to study how tumor cells become circulating cells and then invade and sequentially colonize the bone are in great need. Advances in tissue engineering technologies offers reliable 3D tissue alternatives which answer relevant research questions towards the understanding of cancer evolution and key functional properties of metastasis progression as well as prognosis of therapeutic approach. Here we performed an overview of cellular mechanisms involved in bone metastasis including a short summary of normal bone physiology and metastasis initiation and progression. Also, we comprehensively summarized current advances and methodologies in fabrication of reliable bone tumor models based on state-of-the-art printing technologies which recapitulate structural and biological features of native tissue. STATEMENT OF SIGNIFICANCE: This review provides a comprehensive summary of the collective findings in relation to various printed bone metastasis models utilized for investigating specific bone metastasis diseases, related characteristic functions and chemotherapeutic drug screening. These tumoral models are comprehensively evaluated and compared, in terms of their ability to recapitulate physiological metastasis microenvironment. Various biomaterials (natural and synthetic polymers and ceramic based substrates) and printing strategies and design architecture of models used for printing of 3D bone metastasis models are discussed here. This review clearly out-lines current challenges and prospects for 3D printing technologies in bone metastasis research by focusing on the required perspective models for clinical application of these technologies in chemotherapeutic drug screening.
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  • 文章类型: Journal Article
    微针是具有绕过生理屏障的独特能力的微创设备。因此,它们广泛用于从药物/疫苗递送到诊断和化妆品领域的不同应用。最近,天然生物聚合物(特别是碳水化合物和蛋白质)作为具有可定制特征的微针结构的安全和生物相容性材料而受到关注。几篇综述文章涉及基于碳水化合物的微针。这篇综述旨在通过基于PubMed国际数据库的PRISMA指南的系统搜索策略来强调蛋白质的较少注意的作用,科学直接,Scopus,谷歌学者。标题中带有关键字“微针”以及至少一个关键字“生物聚合物”的原始英文文章,丝绸,明胶,胶原蛋白,zein,角蛋白,鱼鳞,贻贝,收集了suckerin\“,并筛选了其中蛋白质具有结构作用的蛋白质。然后,我们专注于基于蛋白质的微针的结构和应用。此外,一些蛋白质生物聚合物的独特特征,使它们成为微针构建的理想选择(例如,优异的机械强度,自粘,和自组装),以及与之相关的挑战进行了审查。总之,到目前为止鉴定的蛋白质似乎不仅有望在未来制造“更好”的微针,而且对设计具有理想特性的仿生结构生物聚合物也很有启发。
    Microneedles are minimally-invasive devices with the unique capability of bypassing physiological barriers. Hence, they are widely used for different applications from drug/vaccine delivery to diagnosis and cosmetic fields. Recently, natural biopolymers (particularly carbohydrates and proteins) have garnered attention as safe and biocompatible materials with tailorable features for microneedle construction. Several review articles have dealt with carbohydrate-based microneedles. This review aims to highlight the less-noticed role of proteins through a systematic search strategy based on the PRISMA guideline from international databases of PubMed, Science Direct, Scopus, and Google Scholar. Original English articles with the keyword \"microneedle(s)\" in their titles along with at least one of the keywords \"biopolymers, silk, gelatin, collagen, zein, keratin, fish-scale, mussel, and suckerin\" were collected and those in which the proteins undertook a structural role were screened. Then, we focused on the structures and applications of protein-based microneedles. Also, the unique features of some protein biopolymers that make them ideal for microneedle construction (e.g., excellent mechanical strength, self-adhesion, and self-assembly), as well as the challenges associated with them were reviewed. Altogether, the proteins identified so far seem not only promising for the fabrication of \"better\" microneedles in the future but also inspiring for designing biomimetic structural biopolymers with ideal characteristics.
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  • 文章类型: Journal Article
    硅藻生物二氧化硅是多孔二氧化硅的重要天然来源,具有三维有序和纳米图案结构,称为硅藻壳。硅藻壳的独特特征,比如它们的高比表面积,热稳定性,生物相容性,和适应性的表面化学,使硅藻有价值的材料高附加值的应用。这些属性使硅藻成为工业用途的特殊成本效益原材料。硅藻生物二氧化硅表面的功能化改善了其生物物理性质并增加了潜在的应用。本文重点介绍硅藻生物二氧化硅的潜在用途,包括传统方法和生物医学应用的最新进展。不仅涵盖了充分研究的药物递送系统,而且还涵盖了在骨再生和伤口愈合方面的有希望的用途。此外,提出了硅藻生物硅材料使用的相当大的方面和未来可能的方向,以发展生物医学应用并值得进一步探索。
    Diatom biosilica is an important natural source of porous silica, with three-dimensional ordered and nanopatterned structures referred to as frustules. The unique features of diatom frustules, such as their high specific surface area, thermal stability, biocompatibility, and adaptable surface chemistry, render diatoms valuable materials for high value-added applications. These attributes make diatoms an exceptional cost-effective raw material for industrial use. The functionalization of diatom biosilica surface improves its biophysical properties and increases the potential applications. This review focuses on the potential uses of diatom biosilica including traditional approaches and recent progress in biomedical applications. Not only well-studied drug delivery systems but also promising uses on bone regeneration and wound healing are covered. Furthermore, considerable aspects and possible future directions for the use of diatom biosilica materials are proposed to develop biomedical applications and merit further exploration.
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  • 文章类型: Journal Article
    风能领域站在可持续和可再生能源解决方案的最前沿,在缓解环境问题和解决全球能源需求方面发挥着关键作用。多年来,自然启发的解决方案和风能的融合已成为提高风能系统效率和可持续性的有希望的途径。虽然一些研究尝试在风力涡轮机设计和优化的背景下探索仿生原理,涵盖这一跨学科领域的全面审查尤其缺乏。这篇综述论文旨在通过对风能技术领域内利用仿生方法的多方面研究进行分类和分析来纠正这一差距。通过对现有文献进行广泛的调查,我们将各种仿生策略整合到风能领域的设计和优化中。
    The field of wind energy stands at the forefront of sustainable and renewable energy solutions, playing a pivotal role in mitigating environmental concerns and addressing global energy demands. For many years, the convergence of nature-inspired solutions and wind energy has emerged as a promising avenue for advancing the efficiency and sustainability of wind energy systems. While several research endeavors have explored biomimetic principles in the context of wind turbine design and optimization, a comprehensive review encompassing this interdisciplinary field is notably absent. This review paper seeks to rectify this gap by cataloging and analyzing the multifaceted body of research that has harnessed biomimetic approaches within the realm of wind energy technology. By conducting an extensive survey of the existing literature, we consolidate and scrutinize the insights garnered from diverse biomimetic strategies into design and optimization in the wind energy domain.
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    文章类型: Review
    老年人和患有慢性生活方式疾病的患者面临受到环境影响更严重打击的风险。环境影响增加了各种生活方式疾病的风险。仿生学为我们提供了一个独特的机会,可以找到生活方式疾病的新疗法,并抵消环境威胁对健康的影响。通过跨学科合作实现的更好健康的仿生联盟不仅可以促进更好的健康,还可以促进更好,更可持续的环境:对地球有益的东西对我们的健康有益。
    Elderly people and patients with chronic lifestyle diseases are at risk of being hit harder by environmental influences. Environmental impacts increase the risk of various lifestyle diseases. Biomimetics gives us a unique opportunity to find new treatments for lifestyle diseases and counteract health effects of environmental threats. A biomimetic alliance for better health achieved through cross-disciplinal collaboration may not only contribute to better health but also to a better and more sustainable environment: What is good for the planet is good for our health.
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