PDF(Pubmed)
Abstract：
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively analyses recent progress in biomimetics-based cancer theranostics, emphasizing its role in overcoming current treatment challenges, with a focus on breast, prostate, and skin cancers. Biomimetic approaches have been explored to address multidrug resistance (MDR), emphasizing their role in immunotherapy and photothermal therapy. The specific areas covered include biomimetic drug delivery systems bypassing MDR mechanisms, biomimetic platforms for immune checkpoint blockade, immune cell modulation, and photothermal tumor ablation. Pretargeting techniques enhancing radiotherapeutic agent uptake are discussed, along with a comprehensive review of clinical trials of global nanotheranostics. This review delves into biomimetic materials, nanotechnology, and bioinspired strategies for cancer imaging, diagnosis, and targeted drug delivery. These include imaging probes, contrast agents, and biosensors for enhanced specificity and sensitivity. Biomimetic strategies for targeted drug delivery involve the design of nanoparticles, liposomes, and hydrogels for site-specific delivery and improved therapeutic efficacy. Overall, this current review provides valuable information for investigators, clinicians, and biomedical engineers, offering insights into the latest biomimetics applications in cancer theranostics. Leveraging biomimetics aims to revolutionize cancer diagnosis, treatment, and patient outcomes.
摘要：
Nanotheranosics,尤其是那些采用仿生方法的人，对分子成像和癌症治疗具有重要意义。诊断和治疗的结合，被称为癌症治疗药，代表了现代肿瘤学的一个有前途的策略。仿生学,受到大自然的启发,提供了一个有潜力推进癌症治疗的多学科途径。这篇综述全面分析了基于仿生药物的癌症疗法的最新进展，强调其在克服当前治疗挑战中的作用，专注于乳房，前列腺,和皮肤癌。已经探索了仿生方法来解决多药耐药性(MDR)，强调它们在免疫治疗和光热治疗中的作用。涵盖的具体领域包括绕过MDR机制的仿生药物递送系统，免疫检查点封锁的仿生平台，免疫细胞调节，和光热肿瘤消融。讨论了增强放射治疗剂吸收的目标技术，以及对全球nantheranosics临床试验的全面审查。这篇综述深入研究了仿生材料，纳米技术,和生物启发的癌症成像策略，诊断,和靶向药物递送。这些包括成像探头，造影剂,和生物传感器用于增强特异性和灵敏度。靶向药物递送的仿生策略涉及纳米颗粒的设计，脂质体，和水凝胶用于位点特异性递送和改善的治疗功效。总的来说,当前的审查为调查人员提供了宝贵的信息，临床医生,生物医学工程师，提供最新的仿生药物在癌症治疗中的应用的见解。利用仿生学旨在彻底改变癌症诊断，治疗,和患者结果。
