PDF(Pubmed)
Abstract：
Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the \"host\" on protecting the joint life quality and minimizing health risks. Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged \"fellows\" rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all systems in the human body. As long as metabolic pathways are under systemic control and well-concerted together, adaptive mechanisms become triggered increasing systemic protection, activating antioxidant defense and repair machinery. Contextually, all attributes of mitochondrial patho-/physiology are instrumental for predictive medical approach and cost-effective treatments tailored to individualized patient profiles in primary (to protect vulnerable individuals again the health-to-disease transition) and secondary (to protect affected individuals again disease progression) care. Nutraceuticals are naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, and other health-related benefits. Keeping in mind health-promoting properties of nutraceuticals along with their great therapeutic potential and safety profile, there is a permanently growing demand on the application of mitochondria-relevant nutraceuticals. Application of nutraceuticals is beneficial only if meeting needs at individual level. Therefore, health risk assessment and creation of individualized patient profiles are of pivotal importance followed by adapted nutraceutical sets meeting individual needs. Based on the scientific evidence available for mitochondria-relevant nutraceuticals, this article presents examples of frequent medical conditions, which require protective measures targeted on mitochondria as a holistic approach following advanced concepts of predictive, preventive, and personalized medicine (PPPM/3PM) in primary and secondary care.
摘要：
尽管它们在人类中处于从属地位，在很大程度上,线粒体保持其独立状态，但与“宿主”紧密合作，以保护关节生活质量并将健康风险降至最低。在氧化应激条件下，健康的线粒体会迅速增加线粒体自噬水平，以清除受损的“研究员”，使线粒体种群恢复活力，并将mtDNA片段作为SOS信号发送到人体所有系统。只要代谢途径处于系统控制之下并且协调良好，自适应机制成为触发增加的系统保护，激活抗氧化防御和修复机械。上下文中,线粒体病理/生理学的所有属性都有助于预测医学方法和成本效益高的治疗方法,在初级(再次保护弱势个体从健康到疾病的过渡)和次级(再次保护受影响个体的疾病进展)护理中,针对个性化的患者概况定制.Nutraceuticals是天然存在的生物活性化合物，表现出促进健康，预防疾病,和其他健康相关的好处。牢记营养保健品的健康促进特性及其巨大的治疗潜力和安全性，对线粒体相关营养品的应用需求不断增长。只有在满足个人需求的情况下，营养食品的应用才是有益的。因此,健康风险评估和个性化患者档案的创建至关重要，其次是适应个人需求的营养保健品。根据线粒体相关营养食品的科学证据，这篇文章介绍了常见的医疗条件的例子，这需要针对线粒体的保护措施作为一种整体方法，遵循先进的预测概念，预防性,以及初级和二级保健中的个性化医疗(PPPM/3PM)。
