肺癌,全球公认的恶性肿瘤相关发病率和死亡率的主要原因,以其高流行率和高杀伤力为标志,引起医学界的广泛关注。线粒体自噬是一个关键的细胞过程,在调节代谢和确保细胞内的质量控制中起着至关重要的作用。它与肺癌的相关性引起了研究人员和科学家的极大关注。线粒体自噬参与肺癌包括其启动,programming,转移性播散和治疗。线粒体自噬的调控景观是复杂的,涉及许多可能在肿瘤环境中表现出异常改变或突变的信号蛋白和途径。在治疗领域,线粒体自噬的调节被认为是决定癌症化疗的关键,放射治疗,其他治疗方案,和抗药性。当代研究旨在利用线粒体自噬调节剂,抑制剂和活化剂,在治疗策略中,重点是实现特异性,以最大程度地减少对健康细胞群体的附带损害。此外,与线粒体自噬相关的分子成分和途径,作为潜在的生物标志物,为提高诊断准确性提供有希望的途径,预后评估,和预测肺癌的治疗反应。未来的努力还将涉及研究线粒体自噬对肿瘤微环境中免疫细胞的组成和功能的影响。旨在增强我们对线粒体自噬如何调节对肺癌的免疫反应的理解。本综述旨在全面概述线粒体自噬在肿瘤发生中的作用的最新进展。子代和转移,以及线粒体自噬对肺癌治疗的影响。我们还讨论了线粒体自噬在肺癌领域的未来研究方向。
Lung cancer, recognized globally as a leading cause of malignancy-associated morbidity and mortality, is marked by its high prevalence and lethality, garnering extensive attention within the medical community.
Mitophagy is a critical cellular process that plays a crucial role in regulating metabolism and ensuring quality control within cells. Its relevance to lung cancer has garnered significant attention among researchers and scientists. Mitophagy\'s involvement in lung cancer encompasses its initiation, progression, metastatic dissemination and treatment. The regulatory landscape of
mitophagy is complex, involving numerous signaling proteins and pathways that may exhibit aberrant alterations or mutations within the tumor environment. In the field of treatment, the regulation of mitophagy is considered key to determining cancer chemotherapy, radiation therapy, other treatment options, and drug resistance. Contemporary investigations are directed towards harnessing
mitophagy modulators, both inhibitors and activators, in therapeutic strategies, with an emphasis on achieving specificity to minimize collateral damage to healthy cellular populations. Furthermore, molecular constituents and pathways affiliated with mitophagy, serving as potential biomarkers, offer promising avenues for enhancing diagnostic accuracy, prognostic assessment, and prediction of therapeutic responses in lung cancer. Future endeavors will also involve investigating the impact of mitophagy on the composition and function of immune cells within the tumor microenvironment, aiming to enhance our understanding of how mitophagy modulates the immune response to lung cancer. This review aims to comprehensively overview recent advancements about the role of mitophagy in the tumor genesis, progenesis and metastasis, and the impact of
mitophagy on the treatment of lung cancer. We also discussed the future research direction of
mitophagy in the field of lung cancer.