关键词： AA, Arachidonic acid ADH, Alcohol dehydrogenase AH, Alcoholic hepatitis ALD, Alcohol-associated liver disease ALDH, Aldehyde dehydrogenase ALT, Alanine transaminase ASH, Alcohol-associated steatohepatitis AST, Aspartate transaminase AUD, Alcohol use disorder BHMT, Betaine-homocysteine-methyltransferase CD, Cluster of differentiation COX, Cycloxygenase CTLs, Cytotoxic T-lymphocytes CYP, Cytochrome P450 CYP2E1, Cytochrome P450 2E1 Cu/Zn SOD, Copper/zinc superoxide dismutase DAMPs, Damage-associated molecular patterns DC, Dendritic cells EDN1, Endothelin 1 ER, Endoplasmic reticulum ETOH, Ethanol EVs, Extracellular vesicles FABP4, Fatty acid-binding protein 4 FAF2, Fas-associated factor family member 2 FMT, Fecal microbiota transplant Fn14, Fibroblast growth factor-inducible 14 GHS-R1a, Growth hormone secretagogue receptor type 1a GI, GOsteopontinastrointestinal tract GSH Px, Glutathione peroxidase GSSG Rdx, Glutathione reductase GST, Glutathione-S-transferase GWAS, Genome-wide association studies H2O2, Hydrogen peroxide HA, Hyaluronan HCC, Hepatocellular carcinoma HNE, 4-hydroxynonenal HPMA, 3-hydroxypropylmercapturic acid HSC, Hepatic stellate cells HSD17B13, 17 beta hydroxy steroid dehydrogenase 13 HSP 90, Heat shock protein 90 IFN, Interferon IL, Interleukin IRF3, Interferon regulatory factor 3 JAK, Janus kinase KC, Kupffer cells LCN2, Lipocalin 2 M-D, Mallory–Denk MAA, Malondialdehyde-acetaldehyde protein adducts MAT, Methionine adenosyltransferase MCP, Macrophage chemotactic protein MDA, Malondialdehyde MIF, Macrophage migration inhibitory factor Mn SOD, Manganese superoxide dismutase Mt, Mitochondrial NK, Natural killer NKT, Natural killer T-lymphocytes OPN, Osteopontin PAMP, Pathogen-associated molecular patterns PNPLA3, Patatin-like phospholipase domain containing 3 PUFA, Polyunsaturated fatty acid RIG1, Retinoic acid inducible gene 1 SAH, S-adenosylhomocysteine SAM, S-adenosylmethionine SCD, Stearoyl-CoA desaturase STAT, Signal transduction and activator of transcription TIMP1, Tissue inhibitor matrix metalloproteinase 1 TLR, Toll-like receptor TNF, Tumor necrosis factor-α alcohol alcohol-associated liver disease ethanol metabolism liver miRNA, MicroRNA p90RSK, 90 kDa ribosomal S6 kinase

来  源：   DOI：10.1016/j.jceh.2022.05.004   PDF(Pubmed)

Abstract：
Excessive alcohol consumption is a global healthcare problem with enormous social, economic, and clinical consequences. While chronic, heavy alcohol consumption causes structural damage and/or disrupts normal organ function in virtually every tissue of the body, the liver sustains the greatest damage. This is primarily because the liver is the first to see alcohol absorbed from the gastrointestinal tract via the portal circulation and second, because the liver is the principal site of ethanol metabolism. Alcohol-induced damage remains one of the most prevalent disorders of the liver and a leading cause of death or transplantation from liver disease. Despite extensive research on the pathophysiology of this disease, there are still no targeted therapies available. Given the multifactorial mechanisms for alcohol-associated liver disease pathogenesis, it is conceivable that a multitherapeutic regimen is needed to treat different stages in the spectrum of this disease.
摘要：
过度饮酒是一个全球性的医疗保健问题，具有巨大的社会，经济,和临床后果。虽然慢性，大量饮酒会导致身体几乎每个组织的结构损伤和/或破坏正常器官功能，肝脏受到的损害最大。这主要是因为肝脏是第一个通过门静脉循环从胃肠道吸收酒精的，因为肝脏是乙醇代谢的主要部位。酒精引起的损伤仍然是肝脏最普遍的疾病之一，也是肝脏疾病死亡或移植的主要原因。尽管对这种疾病的病理生理学进行了广泛的研究，目前还没有靶向治疗.鉴于酒精相关性肝病发病机制的多因素机制，可以想象，需要多种治疗方案来治疗该疾病谱中的不同阶段。
公众号