酒精相关性肝病的发病机制。
关键词: AA, Arachidonic acid ADH, Alcohol dehydrogenase AH, Alcoholic hepatitis ALD, Alcohol-associated liver disease ALDH, Aldehyde dehydrogenase ALT, Alanine transaminase ASH, Alcohol-associated steatohepatitis AST, Aspartate transaminase AUD, Alcohol use disorder BHMT, Betaine-homocysteine-methyltransferase CD, Cluster of differentiation COX, Cycloxygenase CTLs, Cytotoxic T-lymphocytes CYP, Cytochrome P450 CYP2E1, Cytochrome P450 2E1 Cu/Zn SOD, Copper/zinc superoxide dismutase DAMPs, Damage-associated molecular patterns DC, Dendritic cells EDN1, Endothelin 1 ER, Endoplasmic reticulum ETOH, Ethanol EVs, Extracellular vesicles FABP4, Fatty acid-binding protein 4 FAF2, Fas-associated factor family member 2 FMT, Fecal microbiota transplant Fn14, Fibroblast growth factor-inducible 14 GHS-R1a, Growth hormone secretagogue receptor type 1a GI, GOsteopontinastrointestinal tract GSH Px, Glutathione peroxidase GSSG Rdx, Glutathione reductase GST, Glutathione-S-transferase GWAS, Genome-wide association studies H2O2, Hydrogen peroxide HA, Hyaluronan HCC, Hepatocellular carcinoma HNE, 4-hydroxynonenal HPMA, 3-hydroxypropylmercapturic acid HSC, Hepatic stellate cells HSD17B13, 17 beta hydroxy steroid dehydrogenase 13 HSP 90, Heat shock protein 90 IFN, Interferon IL, Interleukin IRF3, Interferon regulatory factor 3 JAK, Janus kinase KC, Kupffer cells LCN2, Lipocalin 2 M-D, Mallory–Denk MAA, Malondialdehyde-acetaldehyde protein adducts MAT, Methionine adenosyltransferase MCP, Macrophage chemotactic protein MDA, Malondialdehyde MIF, Macrophage migration inhibitory factor Mn SOD, Manganese superoxide dismutase Mt, Mitochondrial NK, Natural killer NKT, Natural killer T-lymphocytes OPN, Osteopontin PAMP, Pathogen-associated molecular patterns PNPLA3, Patatin-like phospholipase domain containing 3 PUFA, Polyunsaturated fatty acid RIG1, Retinoic acid inducible gene 1 SAH, S-adenosylhomocysteine SAM, S-adenosylmethionine SCD, Stearoyl-CoA desaturase STAT, Signal transduction and activator of transcription TIMP1, Tissue inhibitor matrix metalloproteinase 1 TLR, Toll-like receptor TNF, Tumor necrosis factor-α alcohol alcohol-associated liver disease ethanol metabolism liver miRNA, MicroRNA p90RSK, 90 kDa ribosomal S6 kinase
来 源:
DOI:10.1016/j.jceh.2022.05.004
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