这篇综述讨论了男女不孕症与营养相关参数的表观遗传机制和关系。全世界不孕症的患病率为8-12%,每八对夫妇中就有一对接受治疗。表观遗传机制,老化,环境因素,膳食能量和营养素以及非营养化合物;或多或少的能量摄入,和蛋氨酸在不孕症的发生中起作用。它还与维生素B12,D和B6,生物素,胆碱,硒,锌,叶酸,白藜芦醇,槲皮素和类似因素。了解影响不育基因表达的分子机制,环境,基因型的作用,年龄,健康,首先必须考虑营养和个体表观基因型的变化。这将为鉴定不孕症的未知原因铺平道路。能量和某些宏量和微量营养素摄入不足或过多也可能导致不孕症的发生。此外,据报道,5-10%的体重下降,适度的体力活动和营养干预改善胰岛素敏感性有助于生育能力的发展.与表观遗传学有关的过程携带遗传但未通过DNA序列编码的改变。营养被认为对表观遗传机制有影响,所述表观遗传机制在几种疾病如不孕症的发病机理中有效。不育个体的表观遗传机制与健康个体不同。不孕症与表观遗传机制有关,营养素,生物活性成分和许多其他因素。
This review discusses epigenetic mechanisms and the relationship of infertility in men and women in relation to parameters pertaining to nutrition. The prevalence of infertility worldwide is 8-12 %, and one out of every eight couples receives medical treatment. Epigenetic mechanisms, aging, environmental factors, dietary energy and nutrients and non-nutrient compounds; more or less energy intake, and methionine come into play in the occurrence of infertility. It also interacts with vitamins B12, D and B6, biotin, choline, selenium, zinc, folic acid, resveratrol, quercetin and similar factors. To understand the molecular mechanisms regulating the expression of genes that affect infertility, the environment, the role of genotype, age, health, nutrition and changes in the individual\'s epigenotype must first be considered. This will pave the way for the identification of the unknown causes of infertility. Insufficient or excessive intake of energy and certain macro and micronutrients may contribute to the occurrence of infertility as well. In addition, it is reported that 5-10 % of body weight loss, moderate physical activity and nutritional interventions for improvement in insulin sensitivity contribute to the development of fertility. Processes that pertain to epigenetics carry alterations which are inherited yet not encoded via the DNA sequence. Nutrition is believed to have an impact over the epigenetic mechanisms which are effective in the pathogenesis of several diseases like infertility. Epigenetic mechanisms of individuals with infertility are different from healthy individuals. Infertility is associated with epigenetic mechanisms, nutrients, bioactive components and numerous other factors.