■据报道,运动对非酒精性脂肪性肝病(NAFLD)管理的减肥无关有益效果,但潜在的机制是未知的。为了帮助确定这种机制,运动对个体组织(肝脏,脂肪组织,和骨骼肌)进行了回顾性研究。
■分析了在3个月运动方案中患有NAFLD的日本肥胖男性的数据,并与旨在实现体重减轻的3个月饮食限制计划中的数据进行了比较。在一个较小的子队列中研究了潜在的机制。
■与减肥效果无关,运动方案减少肝脏脂肪变性9.5%和肝脏硬度6.8%每1%的体重减轻,并导致FibroScan-AST评分降低16.4%。这些肝脏参数的改善与人体测量变化密切相关(脂肪组织减少和肌肉质量保持),肌肉力量增加(+11.6%),减少炎症和氧化应激(铁蛋白:-22.3%和硫代巴比妥酸:-12.3%),和有机因子浓度的变化(硒蛋白-P:-11.2%,卵泡抑素:+17.1%,脂联素:+8.9%,和肌肉生长抑制素:-21.6%)在运动方案中。此外,转录因子Nrf2的靶基因的表达,Nrf2是一种氧化应激传感器,在单核细胞中更高,表明Nrf2被激活。大量高强度运动可有效进一步减少肝脏脂肪变性并增强病理生理参数(肝酶活性和有机因子谱)的改善。
■运动的与体重减轻无关的益处包括对NAFLD患者肝脏的抗脂肪变性和抗僵硬作用。这些好处似乎是通过改变器官间的串扰获得的,其特征是改善了有机因子失衡,减少了炎症和氧化应激。
■我们研究了运动对非酒精性脂肪性肝病(NAFLD)的影响,但与体重减轻无关。我们发现,运动通过多种机制对肝脏具有相当大的减肥无关的益处。这表明运动对NAFLD患者很重要,不管他们是否减肥。
UNASSIGNED: A weight-loss-independent beneficial effect of exercise on non-alcoholic fatty liver disease (NAFLD) management has been reported, but the underlying mechanism is unknown. To help determine this mechanism, the effects of exercise on individual tissues (liver, adipose tissue, and skeletal muscle) were retrospectively studied.
UNASSIGNED: Data from Japanese obese men with NAFLD in a 3-month exercise regimen were analysed and compared with those in a 3-month dietary restriction program designed to achieve weight loss. The underlying mechanism was studied in a smaller subcohort.
UNASSIGNED: Independent of the effect of weight loss, the exercise regimen reduced liver steatosis by 9.5% and liver stiffness by 6.8% per 1% weight loss, and resulted in a 16.4% reduction in FibroScan-AST score. Improvements in these hepatic parameters were closely associated with anthropometric changes (reduction in adipose tissue and preservation of muscle mass), increases in muscle strength (+11.6%), reductions in inflammation and oxidative stress (ferritin: -22.3% and thiobarbituric acid: -12.3%), and changes in organokine concentrations (selenoprotein-P: -11.2%, follistatin: +17.1%, adiponectin: +8.9%, and myostatin: -21.6%) during the exercise regimen. Moreover, the expression of target genes of the transcription factor Nrf2, an oxidative stress sensor, was higher in monocytes, suggesting that Nrf2 is activated. Large amounts of high-intensity exercise were effective at further reducing liver steatosis and potentiating improvements in pathophysiological parameters (liver enzyme activities and organokine profiles).
UNASSIGNED: The weight-loss-independent benefits of exercise include anti-steatotic and anti-stiffness effects in the livers of patients with NAFLD. These benefits seem to be acquired through the modification of inter-organ crosstalk, which is characterised by improvements in organokine imbalance and reductions in inflammation and oxidative stress.
UNASSIGNED: We investigated the effects of exercise on non-alcoholic fatty liver disease (NAFLD) that were not related to weight loss. We found that exercise had considerable weight-loss-independent benefits for the liver through a number of mechanisms. This suggests that exercise is important for NAFLD patients, regardless of whether they lose weight.