■非酒精性脂肪性肝病(NAFLD)具有多因素起源。遗传和环境因素导致这种复杂疾病的生物学。在这项研究中,我们筛选了NAFLD患者的父母,并将其与非NAFLD患者的父母进行了比较,以了解其家族聚集性和含patatatin样磷脂酶结构域3(PNPLA3)的作用.
■这是一项横断面研究。对患有NAFLD和无NAFLD的先证者的父母进行腹部超声检查,人体测量学,验血,瞬态弹性成像,和PNPLA3多态性。
■我们登记了303个人:51位NAFLD先证者,50个没有NAFLD的先证者,202父母与非NAFLD组的父母相比,NAFLD组的父母具有明显更高的代谢风险因素。他们有明显较高的脂肪肝率(P=0.0001),平均血清天冬氨酸转氨酶水平(P=0.011),平均血清丙氨酸转氨酶水平(P=0.001),提高空腹和餐后血糖水平,较低的平均血小板(P=0.033)和血清白蛋白水平(P=0.005),瞬时弹性成像的平均肝硬度较高(P=0.001)。与非NAFLD组相比,NAFLD组中PNPLA3多态性的频率更高(突变GG-13.3vs3.3%)。同样,NAFLD组的父母有15%的突变GG,而非NAFLD组的父母有5%,(P=0.105,赔率比6),虽然没有统计学意义,但可能是相关的。在这项研究中,非酒精性脂肪性肝炎父母的后代可能具有GG纯合等位基因。计算基于父母参数的NAFLD16评分,以预测超重肥胖个体发生NAFLD的概率。
对NAFLD患者的父母进行筛查将有助于识别未确诊的NAFLD病例和其他代谢危险因素,因为NAFLD具有家族性聚集性。可以使用NAFLD16评分预测下一代中NAFLD的发生。
UNASSIGNED: Nonalcoholic fatty liver disease (NAFLD) has multifactorial origin. Genetic and environmental factors lead to the biology of this complex disorder. In this study, we screened parents of cases with NAFLD and compared them with parents of cases without NAFLD to see its familial aggregation and the role of patatin-like phospholipase domain containing 3 (PNPLA3).
UNASSIGNED: It was a cross-sectional study. Parents of probands with NAFLD and without NAFLD were screened with abdominal sonography, anthropometry, blood tests, transient elastography, and PNPLA3 polymorphism.
UNASSIGNED: We had enrolled 303 individuals: 51 probands with NAFLD, 50 probands without NAFLD, and their 202 parents. Parents of the NAFLD group had significantly higher metabolic risk factors as compared with parents of the non-NAFLD group. They had a significantly higher rate of fatty liver (P = 0.0001), mean serum aspartate aminotransferase levels (P = 0.011), mean serum alanine aminotransferase levels (P = 0.001),raised fasting and postprandial blood sugar levels, lower mean platelets (P = 0.033) and serum albumin levels (P = 0.005), and higher mean liver stiffness (P = 0.001) on transient elastography.Frequency of PNPLA3 polymorphism within NAFLD group was higher compared to the non-NAFLD group (mutant GG-13.3 vs 3.3%). Similarly, parents of NAFLD group had mutant GG in 15 % versus 5% in parents of non-NAFLD group, (P = 0.105, odds ratio 6), though it was not statistically significant but may be relevant. In this study, offsprings of parents with nonalcoholic steatohepatitis were likely to have GG homozygous allele. A NAFLD16 score based on parent\'s parameters was calculated to predict the probability of NAFLD occurrence in an overweight obese individual.
UNASSIGNED: Screening of parents of individuals with NAFLD will help in the identification of undiagnosed NAFLD cases and other metabolic risk factors among them as there is a familial aggregation of NAFLD. One can predict the occurrence of NAFLD in the next generation using the NAFLD16 score.