在阿尔茨海默病药物开发中靶向全身代谢和线粒体生物能学。
关键词: ACE2, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 AD, Alzheimer's disease ADP, adenosine diphosphate ADRD, AD-related dementias Aβ, amyloid β CSF, cerebrospinal fluid Circadian regulation DAMPs DAMPs, damage-associated molecular patterns Diabetes ER, estrogen receptor ETC, electron transport chain FCCP, trifluoromethoxy carbonylcyanide phenylhydrazone FPR-1, formyl peptide receptor 1 GIP, glucose-dependent insulinotropic polypeptide GLP-1, glucagon-like peptide-1 HBP, hexoamine biosynthesis pathway HTRA, high temperature requirement A Hexokinase biosynthesis pathway I3A, indole-3-carboxaldehyde IRF-3, interferon regulatory factor 3 LC3, microtubule associated protein light chain 3 LPS, lipopolysaccharide LRR, leucine-rich repeat MAVS, mitochondrial anti-viral signaling MCI, mild cognitive impairment MRI, magnetic resonance imaging MRS, magnetic resonance spectroscopy Mdivi-1, mitochondrial division inhibitor 1 Microbiome Mitochondrial DNA Mitochondrial electron transport chain Mitochondrial quality control NLRP3, leucine-rich repeat (LRR)-containing protein (NLR)-like receptor family pyrin domain containing 3 NOD, nucleotide-binding oligomerization domain NeuN, neuronal nuclear protein PET, fluorodeoxyglucose (FDG)-positron emission tomography PKA, protein kinase A POLβ, the base-excision repair enzyme DNA polymerase β ROS, reactive oxygen species Reactive species SAMP8, senescence-accelerated mice SCFAs, short-chain fatty acids SIRT3, NAD-dependent deacetylase sirtuin-3 STING, stimulator of interferon genes STZ, streptozotocin SkQ1, plastoquinonyldecyltriphenylphosphonium T2D, type 2 diabetes TCA, Tricarboxylic acid TLR9, toll-like receptor 9 TMAO, trimethylamine N-oxide TP, tricyclic pyrone TRF, time-restricted feeding cAMP, cyclic adenosine monophosphate cGAS, cyclic GMP/AMP synthase hAPP, human amyloid precursor protein hPREP, human presequence protease i.p., intraperitoneal mTOR, mechanistic target of rapamycin mtDNA, mitochondrial DNA αkG, alpha-ketoglutarate
来 源:
DOI:10.1016/j.apsb.2021.06.014
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