糖尿病,一组以持续性高血糖为特征的代谢紊乱,影响着全世界数百万人,并且正在上升。膳食蛋白质,来自广泛的食物来源,富含具有抗糖尿病特性的生物活性肽。值得注意的例子包括AGFAGDDAPR,红茶衍生的肽,VRIRLLQRFNKRS,β-伴大豆球蛋白衍生肽,和乳源肽VPP,通过多种途径,包括改善β细胞功能,在糖尿病啮齿动物模型中显示出抗糖尿病作用,抑制α细胞增殖,抑制食物摄入,增加门静脉胆囊收缩素浓度,增强胰岛素信号和葡萄糖摄取,改善脂肪组织炎症。尽管对生物活性肽的糖调节特性进行了大量研究,这些生物活性肽在功能性食品或营养食品中的掺入由于在肽研究和商业化领域中存在若干挑战而受到广泛限制。在这个领域正在进行的研究,然而,为此目的铺路是至关重要的。
Diabetes mellitus, a group of metabolic disorders characterized by persistent hyperglycemia, affects millions of people worldwide and is on the rise. Dietary proteins, from a wide range of food sources, are rich in bioactive peptides with antidiabetic properties. Notable examples include AGFAGDDAPR, a black tea-derived peptide, VRIRLLQRFNKRS, a β-conglycinin-derived peptide, and milk-derived peptide VPP, which have shown antidiabetic effects in diabetic rodent models through variety of pathways including improving beta-cells function, suppression of alpha-cells proliferation, inhibiting food intake, increasing portal cholecystokinin concentration, enhancing insulin signaling and glucose uptake, and ameliorating adipose tissue inflammation. Despite the immense research on glucoregulatory properties of bioactive peptides, incorporation of these bioactive peptides in functional foods or nutraceuticals is widely limited due to the existence of several challenges in the field of peptide research and commercialization. Ongoing research in this field, however, is fundamental to pave the road for this purpose.