未经批准:乳腺癌(BC)幸存者长期合并症的负担增加,包括心力衰竭(HF)。然而,对HF亚型发展的风险了解有限,例如具有保留射血分数的HF(HFpEF),BC幸存者
UNASSIGNED:本研究旨在评估绝经后BC幸存者中HFpEF和射血分数降低的HF(HFrEF)的发生率,并确定与HF亚型相关的生活方式和心血管危险因素。
未经授权:在妇女健康倡议中,对确诊为侵袭性BC的参与者进行随访,以确定住院HF的发生率,裁定程序确定了左心室射血分数。我们计算了HF的累积发生率,HFpEF,和HFrEF。我们估计了与HF相关的危险因素的HR,HFpEF,和HFrEF使用Cox比例风险生存模型。
未经评估:在2,272BC幸存者中(28.6%的黑人和64.9%的白人),住院HFpEF和HFrEF的累计发病率分别为6.68%和3.96%,分别,中位数为7.2年(IQR:3.6-12.3年)。对于HFpEF,既往心肌梗死(HR:2.83;95%CI:1.28-6.28),腰围更大(HR:1.99;95%CI:1.14-3.49),和吸烟史(HR:1.65;95%CI:1.01-2.67)是多变量模型中最强的危险因素。除了腰围,HFrEF观察到类似的模式,虽然没有一个是重要的。对于那些没有HF的人来说,住院HFpEF的BC幸存者的总死亡率风险为5.65(95%CI:4.11-7.76),在那些住院的HFrEF患者中,它是3.77(95%CI:2.51-5.66)。
未经证实:在这个老年人群中,种族多样化的BC幸存者,HFpEF的发病率,根据HF住院的定义,高于HFrEF。HF也与死亡风险增加相关。HF的危险因素与普通人群很大程度上相似,但先前的HFpEF心肌梗死除外。值得注意的是,腰围和吸烟都是可能改变的因素。
UNASSIGNED: Breast cancer (BC) survivors experience an increased burden of long-term comorbidities, including heart failure (HF). However, there is limited understanding of the risk for the development of HF subtypes, such as HF with preserved ejection fraction (HFpEF), in BC survivors.
UNASSIGNED: This study sought to estimate the incidence of HFpEF and HF with reduced ejection fraction (HFrEF) in postmenopausal BC survivors and to identify lifestyle and cardiovascular risk factors associated with HF subtypes.
UNASSIGNED: Within the Women\'s Health Initiative, participants with an adjudicated diagnosis of invasive BC were followed to determine the incidence of hospitalized HF, for which adjudication procedures determined left ventricular ejection fraction. We calculated cumulative incidences of HF, HFpEF, and HFrEF. We estimated HRs for risk factors in relation to HF, HFpEF, and HFrEF using Cox proportional hazards survival models.
UNASSIGNED: In 2,272 BC survivors (28.6% Black and 64.9% White), the cumulative incidences of hospitalized HFpEF and HFrEF were 6.68% and 3.96%, respectively, over a median of 7.2 years (IQR: 3.6-12.3 years). For HFpEF, prior myocardial infarction (HR: 2.83; 95% CI: 1.28-6.28), greater waist circumference (HR: 1.99; 95% CI: 1.14-3.49), and smoking history (HR: 1.65; 95% CI: 1.01-2.67) were the strongest risk factors in multivariable models. With the exception of waist circumference, similar patterns were observed for HFrEF, although none were significant. In relation to those without HF, the risk of overall mortality in BC survivors with hospitalized HFpEF was 5.65 (95% CI: 4.11-7.76), and in those with hospitalized HFrEF, it was 3.77 (95% CI: 2.51-5.66).
UNASSIGNED: In this population of older, racially diverse BC survivors, the incidence of HFpEF, as defined by HF hospitalizations, was higher than HFrEF. HF was also associated with an increased mortality risk. Risk factors for HF were largely similar to the general population with the exception of prior myocardial infarction for HFpEF. Notably, both waist circumference and smoking represent potentially modifiable factors.