未经证实:成人研究表明,大量营养素摄入对骨骼产生急性抗吸收作用,反映在C端端肽(CTX)的减少,骨吸收的生物标志物,以及肠道来源的肠促胰岛素激素,葡萄糖依赖性促胰岛素多肽(GIP)和胰高血糖素样肽-1(GLP-1),促进这一反应。仍然存在与其他骨转换生物标志物相关的知识差距,以及在达到峰值骨强度的年份中,肠-骨串扰是否有效。这项研究首先,描述了口服葡萄糖耐量试验(OGTT)期间骨吸收的变化,第二,测试OGTT过程中肠促胰岛素和骨生物标志物变化与骨微结构之间的关系。
未经评估:我们对10名年龄在18-25岁的健康新兴成年人进行了一项横断面研究。在多样品2小时75克OGTT,葡萄糖,胰岛素,GIP,GLP-1,CTX,骨特异性碱性磷酸酶(BSAP),骨钙蛋白,骨保护素(OPG),核因子κβ受体活化因子配体(RANKL),硬化蛋白,在第0、30、60和120分钟测定甲状旁腺激素(PTH)。从0-30分钟和0-120分钟计算曲线下的增量面积(iAUC)。使用第二代高分辨率外周定量计算机断层扫描评估胫骨骨微结构。
未经批准:在OGTT期间,葡萄糖,胰岛素,GIP,GLP-1显著增加。CTX在30、60和120min时显著低于0min,到120min时最大降低约53%。葡萄糖-iAUC0-30与CTX-iAUC0-120呈负相关(rho=-0.91,P<0.001),GLP-1-iAUC0-30与BSAP-iAUC0-120呈正相关(rho=0.83,P=0.005),RANKL-iAUC0-120(ρ=0.86,P=0.007),和皮质体积骨密度(rho=0.93,P<0.001)。
未经证实:在骨强度峰值期间,葡萄糖摄入对骨代谢产生抗再吸收作用。在这个关键的生命阶段,肠道和骨骼之间的串扰需要进一步关注。
UNASSIGNED: Studies in adults indicate that macronutrient ingestion yields an acute anti-resorptive effect on bone, reflected by decreases in C-terminal telopeptide (CTX), a biomarker of bone resorption, and that gut-derived incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), facilitate this response. There remain knowledge gaps relating to other biomarkers of bone turnover, and whether gut-bone cross-talk is operative during the years surrounding peak bone strength attainment. This study first, describes changes in bone resorption during oral glucose tolerance testing (OGTT), and second, tests relationships between changes in incretins and bone biomarkers during OGTT and bone micro-structure.
UNASSIGNED: We conducted a cross-sectional study in 10 healthy emerging adults ages 18-25 years. During a multi-sample 2-hour 75 g OGTT, glucose, insulin, GIP, GLP-1, CTX, bone-specific alkaline phosphatase (BSAP), osteocalcin, osteoprotegerin (OPG), receptor activator of nuclear factor kappa-β ligand (RANKL), sclerostin, and parathyroid hormone (PTH) were assayed at mins 0, 30, 60, and 120. Incremental areas under the curve (iAUC) were computed from mins 0-30 and mins 0-120. Tibia bone micro-structure was assessed using second generation high resolution peripheral quantitative computed tomography.
UNASSIGNED: During OGTT, glucose, insulin, GIP, and GLP-1 increased significantly. CTX at min 30, 60, and 120 was significantly lower than min 0, with a maximum decrease of about 53 % by min 120. Glucose-iAUC0-30 inversely correlated with CTX-iAUC0-120 (rho = -0.91, P < 0.001), and GLP-1-iAUC0-30 positively correlated with BSAP-iAUC0-120 (rho = 0.83, P = 0.005), RANKL-iAUC0-120 (rho = 0.86, P = 0.007), and cortical volumetric bone mineral density (rho = 0.93, P < 0.001).
UNASSIGNED: Glucose ingestion yields an anti-resorptive effect on bone metabolism during the years surrounding peak bone strength. Cross-talk between the gut and bone during this pivotal life stage requires further attention.