临床疗效,中药治疗和管理糖尿病肾病的潜在机制和分子靶点。
关键词: ACEI, angiotensin-converting enzyme inhibitor ADE, adverse event AGEs, advanced glycation end-products AM, mesangial area AMPKα, adenosine monophosphate-activated protein kinase α ARB, angiotensin receptor blocker AREs, antioxidant response elements ATK, protein kinase B BAX, BCL-2-associated X protein BCL-2, B-cell lymphoma 2 BCL-XL, B-cell lymphoma-extra large BMP-7, bone morphogenetic protein-7 BUN, blood urea nitrogen BW, body weight C, control group CCR, creatinine clearance rate CD2AP, CD2-associated protein CHOP, C/EBP homologous protein CI, confidence interval COL-I/IV, collagen I/IV CRP, C-reactive protein CTGF, connective tissue growth factor Chinese medicine D, duration DAG, diacylglycerol DG, glomerular diameter DKD, diabetic kidney disease DM, diabetes mellitus DN, diabetic nephropathy Diabetic kidney disease Diabetic nephropathy EMT, epithelial-to-mesenchymal transition EP, E-prostanoid receptor ER, endoplasmic reticulum ESRD, end-stage renal disease ET-1, endothelin-1 ETAR, endothelium A receptor FBG, fasting blood glucose FN, fibronectin GCK, glucokinase GCLC, glutamate-cysteine ligase catalytic subunit GFR, glomerular filtration rate GLUT4, glucose transporter type 4 GPX, glutathione peroxidase GRB 10, growth factor receptor-bound protein 10 GRP78, glucose-regulated protein 78 GSK-3, glycogen synthase kinase 3 Gαq, Gq protein alpha subunit HDL-C, high density lipoprotein-cholesterol HO-1, heme oxygenase-1 HbA1c, glycosylated hemoglobin Herbal medicine ICAM-1, intercellular adhesion molecule-1 IGF-1, insulin-like growth factor 1 IGF-1R, insulin-like growth factor 1 receptor IKK-β, IκB kinase β IL-1β/6, interleukin 1β/6 IR, insulin receptor IRE-1α, inositol-requiring enzyme-1α IRS, insulin receptor substrate IκB-α, inhibitory protein α JAK, Janus kinase JNK, c-Jun N-terminal kinase LC3, microtubule-associated protein light chain 3 LDL, low-density lipoprotein LDL-C, low density lipoprotein-cholesterol LOX1, lectin-like oxidized LDL receptor 1 MAPK, mitogen-activated protein kinase MCP-1, monocyte chemotactic protein-1 MD, mean difference MDA, malondialdehyde MMP-2, matrix metallopeptidase 2 MYD88, myeloid differentiation primary response 88 Molecular target N/A, not applicable N/O, not observed N/R, not reported NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4 NQO1, NAD(P)H:quinone oxidoreductase 1 NRF2, nuclear factor erythroid 2-related factor 2 OCP, oxidative carbonyl protein ORP150, 150-kDa oxygen-regulated protein P70S6K, 70-kDa ribosomal protein S6 kinase PAI-1, plasminogen activator inhibitor-1 PARP, poly(ADP-Ribose) polymerase PBG, postprandial blood glucose PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α PGE2, prostaglandin E2 PI3K, phosphatidylinositol 3 kinases PINK1, PTEN-induced putative kinase 1 PKC, protein kinase C PTEN, phosphatase and tensin homolog RAGE, receptors of AGE RASI, renin-angiotensin system inhibitor RCT, randomized clinical trial ROS, reactive oxygen species SCr, serum creatinine SD, standard deviation SD-rat, Sprague–Dawley rat SIRT1, sirtuin 1 SMAD, small mothers against decapentaplegic SMD, standard mean difference SMURF-2, SMAD ubiquitination regulatory factor 2 SOCS, suppressor of cytokine signaling proteins SOD, superoxide dismutase STAT, signal transducers and activators of transcription STZ, streptozotocin Signaling pathway T, treatment group TBARS, thiobarbituric acid-reactive substance TC, total cholesterol TCM, traditional Chinese medicine TFEB, transcription factor EB TG, triglyceride TGBM, thickness of glomerular basement membrane TGF-β, tumor growth factor β TGFβR-I/II, TGF-β receptor I/II TII, tubulointerstitial injury index TLR-2/4, toll-like receptor 2/4 TNF-α, tumor necrosis factor α TRAF5, tumor-necrosis factor receptor-associated factor 5 UACR, urinary albumin to creatinine ratio UAER, urinary albumin excretion rate UMA, urinary microalbumin UP, urinary protein VCAM-1, vascular cell adhesion molecule-1 VEGF, vascular endothelial growth factor WMD, weight mean difference XBP-1, spliced X box-binding protein 1 cAMP, cyclic adenosine monophosphate eGFR, estimated GFR eIF2α, eukaryotic initiation factor 2α mTOR, mammalian target of rapamycin p-IRS1, phospho-IRS1 p62, sequestosome 1 protein α-SMA, α smooth muscle actin
来 源:
DOI:10.1016/j.apsb.2020.12.020
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