未经批准:SARS-CoV-2感染导致的COVID-19对全球公共卫生产生了巨大的不利影响。随着COVID-19大流行的发展,世界卫生组织宣布了几种令人担忧的变体(VOCs),包括阿尔法,Beta,Gamma,Delta,还有Omicron.与早期的变体相比,Omicron,现在是一个占主导地位的血统,表现出增强的传递性的特征,向性向上呼吸道转移,和减轻疾病的严重程度。尽管疾病严重程度减轻,但Omicron的强劲传播仍然对大流行控制构成了巨大挑战。在这种情况下,其取向转变可用于发现有效的预防措施。
UNASSIGNED:这篇综述旨在估计绿茶表没食子儿茶素没食子酸酯(EGCG)的潜力,最有效的抗病毒儿茶素,在中和SARS-CoV-2Omicron变体中,基于当前有关EGCG在组织中分布和Omicron向性的知识。
UNASSIGNED:EGCG具有低生物利用度。饮用绿茶后,血浆EGCG水平在亚微摩尔浓度范围内,或在药物干预后达到最低μM浓度。尽管如此,在饮用绿茶或药物干预后,其在上呼吸道中的浓度可能高达数十甚至数百μM。已经开发了一种在咽部递送足够高浓度的EGCG的方法。令人信服的数据表明,数十至数百μM的EGCG可以显着中和SARS-CoV-2,并有效消除SARS-CoV-2诱导的细胞病变效应和斑块形成。因此,EGCG,在上呼吸道表现出过度积累,鉴于Omicron更倾向于上呼吸道,在当前全球对抗COVID-19的斗争中,作为一种抗病毒药物值得更仔细的研究。
UNASSIGNED: COVID-19 due to SARS-CoV-2 infection has had an enormous adverse impact on global public health. As the COVID-19 pandemic evolves, the WHO declared several variants of concern (VOCs), including Alpha, Beta, Gamma, Delta, and Omicron. Compared with earlier variants, Omicron, now a dominant lineage, exhibits characteristics of enhanced transmissibility, tropism shift toward the upper respiratory tract, and attenuated disease severity. The robust transmission of Omicron despite attenuated disease severity still poses a great challenge for pandemic control. Under this circumstance, its tropism shift may be utilized for discovering effective preventive approaches.
UNASSIGNED: This review aims to estimate the potential of green tea epigallocatechin gallate (EGCG), the most potent antiviral catechin, in neutralizing SARS-CoV-2 Omicron variant, based on current knowledge concerning EGCG distribution in tissues and Omicron tropism.
UNASSIGNED: EGCG has a low bioavailability. Plasma EGCG levels are in the range of submicromolar concentrations following green tea drinking, or reach at most low μM concentrations after pharmacological intervention. Nonetheless, its levels in the upper respiratory tract could reach concentrations as high as tens or even hundreds of μM following green tea consumption or pharmacological intervention. An approach for delivering sufficiently high concentrations of EGCG in the pharynx has been developed. Convincing data have demonstrated that EGCG at tens to hundreds of μM can dramatically neutralize SARS-CoV-2 and effectively eliminate SARS-CoV-2-induced cytopathic effects and plaque formation. Thus, EGCG, which exhibits hyperaccumulation in the upper respiratory tract, deserves closer investigation as an antiviral in the current global battle against COVID-19, given Omicron\'s greater tropism toward the upper respiratory tract.