■人们对维生素D的非骨骼作用以及维生素D缺乏与糖尿病等慢性病之间的关系越来越感兴趣。我们的目的是调查胰岛素抵抗(IR)的替代指数之间的关系,和维生素D缺乏/不足绝经后沙特妇女有或没有代谢综合征。
研究人群包括300名年龄在46-88岁之间的绝经后妇女,这些妇女是在阿卜杜勒阿齐兹国王大学医院门诊就诊的妇女中连续招募的。人口统计,人体测量学,并记录生化指标。分析了有和没有代谢综合征的女性的数据。
■腹部肥胖,IR,和维生素D缺乏症在我们的人群样本中非常普遍。在用于定义代谢综合征的成分中;腰围,血清甘油三酯(TG),高密度脂蛋白胆固醇,空腹血糖(FBG)与IR的所有替代指标显着相关。血清维生素D与血清TG呈显著负相关,FBG,和舒张压,在研究队列中。
■这些观察结果提示维生素D缺乏可能与代谢综合征的发病风险有关。IR之间的相互关系,代谢综合征,维生素D缺乏症在沙特人口中特别感兴趣,鉴于这些疾病在该地区的患病率很高。
UNASSIGNED: There is increasing interest in the non-skeletal effects of vitamin D and the relationship between vitamin D deficiency and chronic conditions such as diabetes mellitus. We aimed to investigate the relationship between surrogate indices of insulin resistance (IR), and vitamin D deficiency/insufficiency in postmenopausal Saudi women with and without metabolic syndrome.
UNASSIGNED: The study population consisted of 300 postmenopausal women aged 46-88 years enrolled consecutively from women attending the Outpatient Clinics of King Abdulaziz University Hospital. Demographic, anthropometric, and biochemical parameters were recorded. Data were analyzed for women with and without metabolic syndrome.
UNASSIGNED: Abdominal obesity, IR, and hypovitaminosis D were highly prevalent within our population sample. Of the components used to define metabolic syndrome; waist circumference, serum triglycerides (TG), high density lipoprotein-cholesterol, and fasting blood glucose (FBG) were significantly related with all surrogate measures of IR. Significant inverse correlations were found between serum vitamin D and serum TG, FBG, and diastolic blood pressure, within the study cohort.
UNASSIGNED: These observations suggest that hypovitaminosis D may be associated with the risk of developing metabolic syndrome. Interrelationships between IR, metabolic syndrome, and hypovitaminosis D are of particular interest in Saudi population, given the high prevalence of these conditions in this region.