■外用氯霉素是全球眼科和眼整形手术中使用最普遍的抗生素之一。它对各种不同的病原生物显示出广谱的活性,在眼表上具有良好的耐受性,并显示出优异的局部药代动力学。自2005年以来,氯霉素已在英国的柜台上购买。尽管如此,世界上最大的健康经济体,在过去的30年中,美国实际上已暂停使用它。在这次审查中,我们旨在评估局部氯霉素在眼科和眼整形手术中的应用,并确定其在美国的声誉是否合理.
■我们进行了全面的文献综述,以评估氯霉素的不同方面,提供对药物的详细了解,它的历史背景,收益和感知风险,包括安全问题,以及其在临床实践中使用的临床观点。
■氯霉素的作用机理,这种药物在美国的使用下降的背景,以及药物的证据基础和安全性数据,包括已发表的严重不良事件的病例报告,进行了分析。药物的感知益处,特别是考虑到抗菌素耐药性及其经济影响,被审查了。最后,提出了其在眼科和相关专业的临床实践中使用的观点。
■氯霉素及其局部应用已经被误解了几十年,尤其是在美国。它在整个大西洋的灭亡是由于对证据基础薄弱的可疑联系的过度热情。此后,许多作者验证了的安全性,并证明了其安全性。氯霉素的好处,在抗微生物和财政紧缩时代具有正成本差异的有效广谱制剂,不能低估。其作为眼科手术中的局部治疗剂的可能有效性使其成为眼科抗微生物器械中的有价值的工具。我们鼓励恢复这种有价值但被误解的药物作为简单眼科感染的一线药物。
UNASSIGNED: Topical
chloramphenicol is one of the most ubiquitous antibiotics used in ophthalmology and oculoplastic surgery globally. It shows broad-spectrum activity against a variety of different pathogenic organisms, is well tolerated on the ocular surface and displays excellent topical pharmacokinetics.
Chloramphenicol has been available for purchase over the counter in the United Kingdom since 2005. Despite this, the largest health economy in the world, The United States has had a de-facto moratorium on its use for the past 30 years. In this review, we aim to evaluate topical
chloramphenicol in ophthalmology and oculoplastic surgery and to determine whether its reputation within the US is warranted and justified.
UNASSIGNED: We conducted a comprehensive literature review to evaluate the different facets of chloramphenicol, providing a detailed understanding of the drug, its historical context, the benefits and perceived risks, including safety concerns, and clinical perspectives of its use in clinical practice.
UNASSIGNED: The mechanism of
chloramphenicol, the context around which the drug\'s use in the US declined, and the drug\'s evidence base and safety data, including published case reports of serious adverse events, were analysed. The perceived benefits of the drug, particularly in light of antimicrobial resistance and its economic impact, were reviewed. Finally, perspectives on its use in clinical practice in ophthalmology and associated allied specialities were presented.
UNASSIGNED: Chloramphenicol and its topical application have been misunderstood for many decades, particularly in the United States. Its demise across the Atlantic was due to an overzealous response to a dubious association with a weak evidence base. Numerous authors have since validated the safety profile of the and its safety has been borne out. The benefits of
chloramphenicol, an effective broad-spectrum agent with a positive cost differential in the era of anti-microbial resistance and fiscal tightening, cannot be understated. Its likely effectiveness as a therapeutic topical agent in ophthalmic surgery makes it a valuable tool in the ophthalmic anti-microbial armoury. We would encourage the reinstatement of this valuable yet misunderstood drug as a first-line agent for simple ophthalmic infections.