Abstract：
Despite the beneficial effects of antibiotics such as chloramphenicol (CAP), they exert some destructive impacts on human health. We designed an electrochemical sensor based on reduced graphene oxide (rGO)/Au/Co2CuS4 nanohybrid for determination of CAP in food and biological samples. The Co2CuS4 was synthesized from binuclear metal-organic framework (CoCu-BDC) through a two-step process. Nanohybrid was characterized by X-ray photoelectron spectroscopy and transmission electron microscopy. The rGO/Au/Co2CuS4 provides more active sites and good electrical conductivity to reduce charge transfer resistance and improve the electrocatalytic activity for determination of CAP. The prepared sensor has a wide linear range from 7 to 141 nM with a limit of detection of 2.5 nM and a limit of quantification of 21.92 nM. It also provided high selectivity and repeatability with a relative standard deviation of 2.6%. Stability studies showed that the electrode has acceptable performance with efficiency of 95% after 33 days.
摘要：
尽管抗生素如氯霉素（CAP）的有益作用，它们对人类健康产生一些破坏性影响。我们设计了一种基于还原氧化石墨烯(rGO)/Au/Co2CuS4纳米杂化物的电化学传感器,用于食品和生物样品中CAP的测定。Co2CuS4是由双核金属-有机骨架（CoCu-BDC）通过两步法合成的。通过X射线光电子能谱和透射电子显微镜对纳米杂化物进行了表征。rGO/Au/Co2CuS4提供更多的活性位点和良好的导电性以降低电荷转移电阻并提高用于测定CAP的电催化活性。制备的传感器具有7至141nM的宽线性范围,检测极限为2.5nM,定量极限为21.92nM。它还提供了高选择性和可重复性，相对标准偏差为2.6％。稳定性研究表明,电极在33天后具有可接受的性能,效率为95%。
