目的:本研究旨在比较2%利多卡因(LIDO)和0.5%布比卡因(BUPI)在山羊中的低剂量蛛网膜下腔注射的效果。
方法:6健康,私人拥有的雌性山羊。
方法:在这项随机盲交叉临床试验中,每只山羊接受0.05毫升/千克-1的LIDO,BUPI,或无菌盐溶液进入腰骶蛛网膜下腔,洗了七天。心肺变量,直肠温度,和体感(针刺)和运动(共济失调)功能记录在基线(时间0)和注射后2、5、10、15和30分钟,然后每20分钟一次,直到山羊站立并能够行走。使用Kaplan-Meier存活曲线和Cox比例风险模型比较治疗之间恢复体感和运动功能的时间。线性混合效应模型用于比较治疗之间和随时间的心肺变量。P值≤0.05被认为是显著的。
结果:使用BUPI时,体感恢复时间更长,虽然没有统计学意义。LIDO注射后50(50,67)分钟和BUPI注射后104(101,156)分钟的中位放置时间(P=.031)。LIDO后步行的中位时间为72(54,85)分钟,而BUPI注射后为225(220,245)分钟(P=0.031)。心血管和呼吸变量在治疗之间没有显着差异。
结论:尽管伴BUPI的共济失调时间延长,针刺感觉恢复没有差异。在减少剂量的情况下,LIDO和BUPI都被认为是可以接受的短程序的侧翼,骨盆肢体,或者健康山羊的尾巴。
OBJECTIVE: This study aimed to compare the effects of low-dose subarachnoid injections of 2% lidocaine (LIDO) and 0.5% bupivacaine (BUPI) in goats.
METHODS: 6 healthy, privately owned female goats.
METHODS: In this randomized blind crossover clinical trial, each goat received 0.05 mL/kg-1 of LIDO, BUPI, or sterile saline solution into the lumbosacral subarachnoid space, with a seven-day washout. Cardiorespiratory variables, rectal temperature, and somatosensory (pinprick) and motor (ataxia) functions were recorded at baseline (time 0) and 2, 5, 10, 15, and 30 minutes after injection, then every 20 minutes until the goat was standing and able to walk. Time to regain somatosensory and motor functions was compared between treatments using Kaplan-Meier survival curves and the Cox proportional hazards model. Linear mixed-effects models were used to compare cardiorespiratory variables between treatments and over time. A P value ≤ .05 was considered significant.
RESULTS: Somatosensory recovery was longer with BUPI, though not statistically significant. The median time to stand was 50 (50, 67) minutes after LIDO injection and 104 (101, 156) minutes after BUPI injection (P = .031). The median time to walk was 72 (54, 85) minutes after LIDO versus 225 (220, 245) minutes after BUPI injection (P = .031). Cardiovascular and respiratory variables showed no significant differences between treatments.
CONCLUSIONS: Despite prolonged ataxia with BUPI, pinprick sensation recovery did not differ. At reduced doses, both LIDO and BUPI are deemed acceptable for short procedures of the flank, pelvic limb, or tail in healthy goats.