PDF(Pubmed)
Abstract：
A diagnostic investigation into an outbreak of fatal respiratory disease among young goats in Iowa, USA revealed bronchitis lesions of unknown etiology and secondary bacterial bronchopneumonia. Hypothesis-free metagenomics identified a previously unreported picornavirus (USA/IA26017/2023), and further phylogenetic analysis classified USA/IA26017/2023 as an aphthovirus related to bovine rhinitis B virus. Viral nucleic acid was localized to lesions of bronchitis using in situ hybridization. This marks the first report of a picornavirus putatively causing respiratory disease in goats and highlights the potential for cross-species transmission of aphthoviruses.
摘要：
对爱荷华州幼山羊中致命呼吸道疾病爆发的诊断调查，美国发现病因不明的支气管炎病变和继发性细菌性支气管肺炎。无假说的宏基因组学鉴定出一种以前未报道的小核糖核酸病毒(USA/IA26017/2023)，进一步的系统发育分析将USA/IA26017/2023分类为与牛鼻炎B病毒相关的鼻病毒。使用原位杂交将病毒核酸定位于支气管炎的病变。这标志着小核糖核酸病毒在山羊中可能引起呼吸道疾病的首次报道，并强调了口疮病毒跨物种传播的可能性。
