背景在这项研究中,我们旨在评估患有中心性浆液性脉络膜视网膜病变(CSCR)的印度患者的光学相干断层扫描血管造影(OCTA)参数.方法在眼科对患有CSCR的单侧或双侧疾病的印度患者进行了横断面研究,GuruNanak眼科中心,还有毛拉纳·阿扎德医学院,新德里。眼部症状如视力减退的病史,变态,对比敏感度(CS)降低,获得了色觉缺陷(CV)及其持续时间。详细的眼部检查以获得最佳矫正视力(BCVA),眼内压(IOP),CV,CS完成了。在此之后,进行荧光素眼底血管造影(FFA)和吲哚菁绿血管造影(ICGA).对中央凹厚度(CFT)进行OCT,中央凹下脉络膜厚度(SFCT),神经感觉脱离(NSD),色素上皮脱离(PED),和脉络膜新生血管膜(CNVMs)。进行OCTA成像以检查中央凹无血管区(FAZ)大小,周长和圆度,血管密度(VD),和功能,如放大/扭曲的FAZ,黑暗区域,黑点,异常血管,视网膜脉络膜层和脉络膜层的脉络膜层(CCI)。我们比较了受影响的眼睛与其他眼睛的OCTA特征。结果本研究共纳入40例CSCR患者的52只眼,包括32名(80%)男性和8名(20%)女性,平均年龄为39.3±6.1(24-49)岁。在40名患者中,12(30%)有双边参与。平均CFT为300.3±158.4µ,SFCT为258.5±60.4µ。平均距离BCVA是最小分辨率角(logMAR)0.58±0.32的对数。OCTA显示出诸如扩大/扭曲的FAZ(36.53%的眼睛),暗区(NSD/PED)(84.61%的眼睛),黑斑(PED)(5.76%的眼睛),异常血管(扩张血管/CNVM)(96.15%眼),和CCI(17.30%的眼睛)。平均FAZ面积,周边,圆度为0.40±0.71mm2,41.8±280.0mm,和0.48±0.12。浅表毛细血管丛(SCP)VD为25.4±14.1,深毛细血管丛(DCP)15.0±11.5,外视网膜(OR)5.9±6.8,外视网膜脉络膜毛细血管(ORCC)33.7±16.9,脉络膜毛细血管29.7±17.5,脉络膜29.9±17.5。同伴的眼睛显示出平均FAZ区域,周边,圆度为0.34±0.23mm2,76.8±391.2mm,和0.47±0.11,SCP的VD为25.9±13.6,DCP为16.5±11.7,OR为14.3±14.9,ORCC为38.0±16.5,脉络膜脉络膜为36.3±17.7,脉络膜为35.5±19.2。结论CSCR眼的中央凹和中央凹下脉络膜(SFC)较厚。受影响的眼睛的FAZ区域较大,而周长比对方眼中的要小。在受影响的眼睛中,所有视网膜脉络膜层的VD较低,尽管它在整体OR(p=0.006)和中央凹脉络膜(p=0.022)中显著降低。
Background In this study, we aimed to evaluate optical coherence tomography angiography (OCTA) parameters among Indian patients affected with central serous chorioretinopathy (CSCR). Methodology A cross-sectional study on Indian patients having unilateral or bilateral affection with CSCR was conducted at the Department of Ophthalmology, Guru Nanak Eye Centre, and Maulana Azad Medical College, New Delhi. A history of ocular symptoms such as a diminution of vision, metamorphopsia, decreased contrast sensitivity (CS), and defective color vision (CV) and their duration were obtained. A detailed ocular examination for best-corrected visual acuity (BCVA), intraocular pressure (IOP), CV, and CS was done. Following this, fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed. OCT was done for central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), neurosensory detachment (NSD), pigment epithelial detachment (PED), and choroidal neovascular membranes (CNVMs). The OCTA imaging was done to examine the foveal avascular zone (FAZ) size, perimeter and circularity, vessel density (VD), and features such as enlarged/distorted FAZ, dark areas, dark spots, abnormal vessels, and choriocapillaris island (CCI) in the retino-choroidal layers. We compared the OCTA features of affected eyes with those of fellow eyes. Results The study involved 52 eyes of 40 CSCR patients, including 32 (80%) males and eight (20%) females with a mean age of 39.3 ± 6.1 (24-49) years. Of the 40 patients, 12 (30%) had a bilateral involvement. The mean CFT was 300.3 ± 158.4 µ, and the SFCT was 258.5 ± 60.4 µ. The mean distance BCVA was the logarithm of the minimum angle of resolution (logMAR) 0.58 ± 0.32. The OCTA showed features such as enlarged/distorted FAZ (36.53% eyes), dark areas (NSD/PED) (84.61% eyes), dark spots (PED) (5.76% eyes), abnormal vessels (dilated vessels/CNVM) (96.15% eyes), and CCI (17.30% eyes). The mean FAZ area, perimeter, and circularity were 0.40 ± 0.71 mm2, 41.8 ± 280.0 mm, and 0.48 ± 0.12, respectively. The VD in the superficial capillary plexus (SCP) was 25.4 ± 14.1, deep capillary plexus (DCP) 15.0 ± 11.5, outer retina (OR) 5.9 ± 6.8, outer retinal choriocapillaris (ORCC) 33.7 ± 16.9, choriocapillaris 29.7 ± 17.5, and choroid 29.9 ± 17.5. The fellow eyes showed a mean FAZ area, perimeter, and circularity of 0.34 ± 0.23 mm2, 76.8 ± 391.2 mm, and 0.47 ± 0.11, respectively, while VD of SCP was 25.9 ± 13.6, DCP 16.5 ± 11.7, OR 14.3 ± 14.9, ORCC 38.0 ± 16.5, choriocapillaris 36.3 ± 17.7, and choroid 35.5 ± 19.2. Conclusions The CSCR eyes had a thicker fovea and sub-foveal choroid (SFC). The FAZ area of affected eyes was larger, while the perimeter was smaller than that in the fellow eye. In the affected eye, the VD in all the retino-choroidal layers was lower, although it was significantly reduced in OR whole (p = 0.006) and foveal choroid (p = 0.022).