Abstract：
OBJECTIVE: The aim is to evaluate subclinical alterations of macular microvasculature in patients with juvenile systemic lupus erythematosus (JSLE).
METHODS: This is a cross-sectional study of 29 eyes of 29 patients diagnosed with JSLE and 29 eyes of 29 healthy controls. The vessel density (VD) of the superficial capillary plexus (SCP), intermediate capillary plexus (ICP), deep capillary plexus (DCP), choriocapillaris (CC), and area of foveal avascular zone (FAZ) was measured using optical coherence tomography angiography (OCTA). A multiple linear regression analysis was performed to evaluate the effects of disease duration and activity on OCTA parameters.
RESULTS: The VD of total (p = .007) and the superior (p = .014) and inferior (p = .004) quadrants in SCP was significantly lower in children with JSLE. The VD of total and all quadrants in ICP decreased (p = .015, p = .0045, p = .015, p = .033), except that of the temporal quadrant (p = .366). The total (p = .011) and superior quadrant (p<.01) DCP-VD showed a significant decrease in children with JSLE. The decrease in VD in the total (p = .003) and nasal quadrant (p = .017) of CC was also remarkable. No significant difference in the FAZ area was found between the two groups (p = .774). Multiple linear regression analyses adjusted for age, spherical equivalent, and intraocular pressure were conducted. No contributing factor to OCTA parameters was found.
CONCLUSIONS: We demonstrated decreased VD in all layers of the retina and CC in patients with JSLE without ocular involvement. Early screening and close follow-up were recommended.
METHODS: This is a cross-sectional study of 29 eyes of 29 patients diagnosed with JSLE and 29 eyes of 29 healthy controls. The vessel density (VD) of the superficial capillary plexus (SCP), intermediate capillary plexus (ICP), deep capillary plexus (DCP), choriocapillaris (CC), and area of foveal avascular zone (FAZ) was measured using optical coherence tomography angiography (OCTA). A multiple linear regression analysis was performed to evaluate the effects of disease duration and activity on OCTA parameters.
RESULTS: The VD of total (p = .007) and the superior (p = .014) and inferior (p = .004) quadrants in SCP was significantly lower in children with JSLE. The VD of total and all quadrants in ICP decreased (p = .015, p = .0045, p = .015, p = .033), except that of the temporal quadrant (p = .366). The total (p = .011) and superior quadrant (p<.01) DCP-VD showed a significant decrease in children with JSLE. The decrease in VD in the total (p = .003) and nasal quadrant (p = .017) of CC was also remarkable. No significant difference in the FAZ area was found between the two groups (p = .774). Multiple linear regression analyses adjusted for age, spherical equivalent, and intraocular pressure were conducted. No contributing factor to OCTA parameters was found.
CONCLUSIONS: We demonstrated decreased VD in all layers of the retina and CC in patients with JSLE without ocular involvement. Early screening and close follow-up were recommended.
摘要：
目的：目的是评估青少年系统性红斑狼疮（JSLE）患者黄斑微血管的亚临床改变。
方法：这是一项横断面研究，包括29例诊断为JSLE的患者的29只眼和29例健康对照者的29只眼。浅表毛细血管丛（SCP）的血管密度（VD），中间毛细血管丛（ICP），深毛细血管丛（DCP），脉络膜毛细血管（CC），使用光学相干断层扫描血管造影（OCTA）测量中央凹无血管区（FAZ）的面积。进行多元线性回归分析以评估疾病持续时间和活动对OCTA参数的影响。
结果：SCP中总象限（p=.007）和上象限（p=.014）和下象限（p=.004）的VD在JSLE儿童中显著降低。ICP中总象限和所有象限的VD均下降（p=.015，p=.0045，p=.015，p=.033），除了时间象限(p=.366)。总（p=.011）和上象限（p<.01）DCP-VD在JSLE患儿中显示出显著下降。CC的总（p=.003）和鼻象限（p=.017）中VD的降低也是显着的。两组之间的FAZ面积没有显着差异（p=0.774）。多元线性回归分析调整了年龄，球形当量，并进行了眼压测定。没有发现OCTA参数的影响因素。
结论：我们证实，在没有眼部受累的JSLE患者中，视网膜和CC的所有层VD均降低。建议早期筛查和密切随访。
方法：这是一项横断面研究，包括29例诊断为JSLE的患者的29只眼和29例健康对照者的29只眼。浅表毛细血管丛（SCP）的血管密度（VD），中间毛细血管丛（ICP），深毛细血管丛（DCP），脉络膜毛细血管（CC），使用光学相干断层扫描血管造影（OCTA）测量中央凹无血管区（FAZ）的面积。进行多元线性回归分析以评估疾病持续时间和活动对OCTA参数的影响。
结果：SCP中总象限（p=.007）和上象限（p=.014）和下象限（p=.004）的VD在JSLE儿童中显著降低。ICP中总象限和所有象限的VD均下降（p=.015，p=.0045，p=.015，p=.033），除了时间象限(p=.366)。总（p=.011）和上象限（p<.01）DCP-VD在JSLE患儿中显示出显著下降。CC的总（p=.003）和鼻象限（p=.017）中VD的降低也是显着的。两组之间的FAZ面积没有显着差异（p=0.774）。多元线性回归分析调整了年龄，球形当量，并进行了眼压测定。没有发现OCTA参数的影响因素。
结论：我们证实，在没有眼部受累的JSLE患者中，视网膜和CC的所有层VD均降低。建议早期筛查和密切随访。
