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Abstract：
Purpose: We aimed to analyze retinal microvascular parameters, measured by optical coherence tomography angiography in patients with internal carotid artery stenosis compared to healthy individuals. Materials and Methods: A total of 41 eyes from 30 patients who had varying degrees of carotid stenosis, and 42 eyes from 42 healthy controls, were enrolled in this study. Depending on the degree of stenosis evaluated by Doppler ultrasonographic imaging, the patient group was further subclassified into mild, moderate, and severe carotid artery stenosis. Superficial and deep capillary plexus vessel densities, radial peripapillary capillary vessel density, foveal avascular zone, and flow densities in the choriocapillaris and outer retina were evaluated by optical coherence tomography angiography. Results: The superficial and deep capillary plexus vessel densities were significantly reduced among the groups, only sparing the foveal region. The mean superficial plexus vessel density was 45.67 ± 4.65 and 50.09 ± 4.05 for the patient and control group, respectively (p = 0.000). The mean deep capillary plexus density was 46.33% ± 7.31% and 53.27% ± 6.31% for the patient and control group, respectively (p = 0.000). The mean superficial and deep capillary vessel densities in the foveal region did not show any statistical difference between the patient and control groups (p = 0.333 for the superficial and p = 0.195 for the deep plexus vessel density). Radial peripapillary capillary vessel density was decreased in the patient group (p = 0.004). The foveal avascular zone area was wider in the patient group but this difference did not show a significant difference (p = 0.385). Conclusions: Retinal microvascular changes are a prominent outcome of internal carotid disease, and even mild stenosis can lead to alterations in the retinal microvascular bed which could be detected by OCTA. By early detection of microvascular changes in the retina in this patient group, we might speculate the overall vascular condition.
摘要：
目的：我们旨在分析视网膜微血管参数，通过光学相干断层扫描血管造影测量颈内动脉狭窄患者与健康个体的比较。材料与方法：30例不同程度颈动脉狭窄患者共41只眼，和42只健康对照的42只眼睛，参加了这项研究。根据多普勒超声成像评估的狭窄程度，患者组进一步细分为轻度，中度,和严重的颈动脉狭窄.浅层和深层毛细血管丛血管密度，径向乳头状周围毛细血管密度，中央凹无血管区，通过光学相干断层扫描血管造影评估脉络膜毛细血管和外视网膜的血流密度。结果:各组间浅、深毛细血管丛血管密度明显降低,只保留中央凹区域。患者和对照组的平均浅丛血管密度为45.67±4.65和50.09±4.05，分别为(p=0.000)。患者和对照组的平均深毛细血管丛密度为46.33％±7.31％和53.27％±6.31％，分别为(p=0.000)。中央凹区域的平均浅表和深毛细血管密度在患者组和对照组之间没有任何统计学差异（浅表血管密度p=0.333，深丛血管密度p=0.195）。患者组桡骨乳头状周围毛细血管密度降低（p=0.004）。患者组的中央凹无血管区面积较宽，但这种差异没有显着差异（p=0.385）。结论:视网膜微血管改变是颈内动脉疾病的主要结果,甚至轻度狭窄也可能导致视网膜微血管床的改变，这可以通过OCTA检测到。通过早期检测该患者组视网膜的微血管变化，我们可以推测整个血管状况.
