{Reference Type}: Journal Article
{Title}: Perfusion Deficits in Diabetes Without Retinopathy Localize to the Perivenular Deep Capillaries Near the Fovea on OCT Angiography.
{Author}: Nesper PL;Fawzi AA;
{Journal}: Ophthalmol Sci
{Volume}: 4
{Issue}: 5
{Year}: 2024 Sep-Oct
暂无{DOI}: 10.1016/j.xops.2024.100482
{Abstract}: <B>UNASSIGNED: </B>To localize early capillary perfusion deficits in patients with diabetes mellitus (DM) without clinical diabetic retinopathy (DR) using averaged OCT angiography (OCTA).<BR><B>UNASSIGNED: </B>Retrospective cross-sectional study.<BR><B>UNASSIGNED: </B>Patients with DM without DR and healthy controls.<BR><B>UNASSIGNED: </B>We measured perfusion deficits in the full retina, superficial capillary plexus (SCP), and deep capillary plexus (DCP) on averaged 3 × 3-mm OCTA images. Perfusion deficits were defined as the percentage of retinal tissue located >30 μm from blood vessels, excluding the foveal avascular zone (FAZ). One eye from each patient was selected based on image quality. We measured deficits in the parafoveal region, the 300 μm surrounding the FAZ, and 300 to 1000 μm surrounding the FAZ. If a capillary layer within one of these regions was significantly different in DM without DR compared with controls, we further characterized the location of perfusion deficit as periarteriolar, perivenular, or the capillaries between these 2 zones.<BR><B>UNASSIGNED: </B>Location of increased perfusion deficits in patients with DM without DR compared with controls.<BR><B>UNASSIGNED: </B>Sixteen eyes from 16 healthy controls were compared with 16 eyes from 16 patients with DM without DR (age 45.1 ± 10.7 and 47.4 ± 15.2 years respectively, P = 0.64). Foveal avascular zone area and perfusion deficits in the entire parafovea and the 300 to 1000-μm ring around the FAZ were not significantly different between groups (P > 0.05 for all). Perfusion deficits in 300 μm around the FAZ were significantly increased in patients with DM without DR in full retinal thickness, SCP, and DCP (P < 0.05 for all). When analyzing the perivenular, periarteriolar, and capillary zones, only the perivenular DCP perfusion deficits were significantly increased (5.03 ± 2.92% in DM without DR and 2.73 ± 1.97% in controls, P = 0.014).<BR><B>UNASSIGNED: </B>Macular perfusion deficits in patients with DM without DR were significantly increased in the region nearest the FAZ, mainly at the perivenular deep capillaries. Further research on these early changes may improve our understanding of the capillaries most susceptible to vascular injury and disruption during diabetes.<BR><B>UNASSIGNED: </B>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.