Abstract：
OBJECTIVE: This cross-sectional optical coherence tomography angiography (OCTA) study aimed to assess the macular and optic nerve head (ONH) vascular density, foveal avascular zone, and outer retina and choriocapillaris flow in oligoarticular juvenile idiopathic arthritis (oJIA).
METHODS: Prospective.
METHODS: Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
RESULTS: Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (p = 0.031 and p = 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (p = 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (p < 0.001, for both) and isolated oJIA-U group compared to the control group (p = 0.008 and p = 0.001, respectively). The VD and thickness parameters of SCP and ONH, FAZ, and outer retina flow area were similar between the groups.
CONCLUSIONS: oJIA patients with and without uveitis revealed a decreased vessel density in the deep parafoveal region and choriocapillaris flow. Our findings suggest that retinal choroidal microvascular changes could be evident in oJIA-U patients without posterior segment involvement as well as oJIA patients without uveitis.
METHODS: Prospective.
METHODS: Twenty-two eyes of 22 oJIA patients with uveitis (oJIA-U), 20 eyes of 20 oJIA patients without uveitis (isolated oJIA), and 26 healthy volunteers of similar ages and sexes were investigated. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated.
RESULTS: Compared with the control group, both the oJIA-U group and isolated oJIA group showed significantly decreased vessel density of parafovea (p = 0.031 and p = 0.047, respectively) in DCP. Choriocapillaris flow area at 1 mm radius was significantly lower in the oJIA-U group compared to the control group (p = 0.001). Choriocapillaris flow area at 2- and 3-mm radius were significantly lower in the oJIA-U group compared to the control group (p < 0.001, for both) and isolated oJIA-U group compared to the control group (p = 0.008 and p = 0.001, respectively). The VD and thickness parameters of SCP and ONH, FAZ, and outer retina flow area were similar between the groups.
CONCLUSIONS: oJIA patients with and without uveitis revealed a decreased vessel density in the deep parafoveal region and choriocapillaris flow. Our findings suggest that retinal choroidal microvascular changes could be evident in oJIA-U patients without posterior segment involvement as well as oJIA patients without uveitis.
摘要：
目的：这项横断面光学相干断层扫描血管造影（OCTA）研究旨在评估黄斑和视神经乳头（ONH）血管密度，中央凹无血管区，少关节幼年特发性关节炎（oJIA）的视网膜和脉络膜毛细血管流。
方法：前瞻性。
方法：22例oJIA葡萄膜炎（oJIA-U）患者的22只眼，20例无葡萄膜炎的oJIA患者的20只眼（孤立的oJIA），调查了26名年龄和性别相似的健康志愿者。浅毛细血管丛(SCP)和深毛细血管丛(DCP),ONH,中央凹无血管区（FAZ）参数，外视网膜的流动区域，和脉络膜毛细血管被评估。
结果：与对照组相比，oJIA-U组和孤立的oJIA组均显示DCP的旁瓣血管密度显着降低（分别为p=0.031和p=0.047）。与对照组相比，oJIA-U组在1mm半径处的脉络膜毛细血管流面积显着降低（p=0.001）。与对照组相比，oJIA-U组在2毫米和3毫米半径处的脉络膜毛细血管流面积显着降低（两者均p<0.001），与对照组相比，孤立的oJIA-U组（p=0.008和p=0.001，分别）。SCP和ONH的VD和厚度参数，FAZ,两组间视网膜外血流面积相似。
结论：oJIA伴和不伴葡萄膜炎的患者显示深的旁凹区域和脉络膜毛细血管流的血管密度降低。我们的发现表明，在无后段受累的oJIA-U患者以及无葡萄膜炎的oJIA患者中，视网膜脉络膜微血管变化可能很明显。
方法：前瞻性。
方法：22例oJIA葡萄膜炎（oJIA-U）患者的22只眼，20例无葡萄膜炎的oJIA患者的20只眼（孤立的oJIA），调查了26名年龄和性别相似的健康志愿者。浅毛细血管丛(SCP)和深毛细血管丛(DCP),ONH,中央凹无血管区（FAZ）参数，外视网膜的流动区域，和脉络膜毛细血管被评估。
结果：与对照组相比，oJIA-U组和孤立的oJIA组均显示DCP的旁瓣血管密度显着降低（分别为p=0.031和p=0.047）。与对照组相比，oJIA-U组在1mm半径处的脉络膜毛细血管流面积显着降低（p=0.001）。与对照组相比，oJIA-U组在2毫米和3毫米半径处的脉络膜毛细血管流面积显着降低（两者均p<0.001），与对照组相比，孤立的oJIA-U组（p=0.008和p=0.001，分别）。SCP和ONH的VD和厚度参数，FAZ,两组间视网膜外血流面积相似。
结论：oJIA伴和不伴葡萄膜炎的患者显示深的旁凹区域和脉络膜毛细血管流的血管密度降低。我们的发现表明，在无后段受累的oJIA-U患者以及无葡萄膜炎的oJIA患者中，视网膜脉络膜微血管变化可能很明显。
