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Abstract：
OBJECTIVE: To detect retinal microvascular variations in obstructive sleep apnea syndrome patients.
METHODS: This prospective, observational case-control study included healthy controls and patients with mild, moderate, and severe obstructive sleep apnea syndrome. Vascular parameters, foveal avascular area, and flow areas in macula-centered, 6.00×6.00 mm2 scan size optical coherence tomography angiography images were compared.
RESULTS: The control group had the highest whole image, parafoveal, and perifoveal vessel density among the groups in both superficial and the deep capillary plexus (all P<0.05). Rapid eye movement sleep apnoea-hypopnoea index was reversely correlated with whole (Rho=-0.195, P=0.034), parafoveal (Rho=-0.242, P=0.008), perifoveal (Rho=-0.187, P=0.045) vessel density in the superficial capillary plexus, and whole (Rho=-0.186, P=0.046), parafoveal (Rho=-0.260, P=0.004), perifoveal (Rho=-0.189, P=0.043) vessel density in the deep capillary plexus, though the mean and non-rapid eye movement sleep apnoea-hypopnoea index related with only parafoveal vessel density in the superficial capillary plexus (Rho=-0.213, P=0.020; Rho=-0.191, P=0.038) and the deep capillary plexus (Rho=-0.254, P=0.005; Rho=-0.194, P=0.035).
CONCLUSIONS: This study shows decreased vessel density and its reverse correlation with the apnoea-hypopnoea index in patients with obstructive sleep apnea syndrome.
METHODS: This prospective, observational case-control study included healthy controls and patients with mild, moderate, and severe obstructive sleep apnea syndrome. Vascular parameters, foveal avascular area, and flow areas in macula-centered, 6.00×6.00 mm2 scan size optical coherence tomography angiography images were compared.
RESULTS: The control group had the highest whole image, parafoveal, and perifoveal vessel density among the groups in both superficial and the deep capillary plexus (all P<0.05). Rapid eye movement sleep apnoea-hypopnoea index was reversely correlated with whole (Rho=-0.195, P=0.034), parafoveal (Rho=-0.242, P=0.008), perifoveal (Rho=-0.187, P=0.045) vessel density in the superficial capillary plexus, and whole (Rho=-0.186, P=0.046), parafoveal (Rho=-0.260, P=0.004), perifoveal (Rho=-0.189, P=0.043) vessel density in the deep capillary plexus, though the mean and non-rapid eye movement sleep apnoea-hypopnoea index related with only parafoveal vessel density in the superficial capillary plexus (Rho=-0.213, P=0.020; Rho=-0.191, P=0.038) and the deep capillary plexus (Rho=-0.254, P=0.005; Rho=-0.194, P=0.035).
CONCLUSIONS: This study shows decreased vessel density and its reverse correlation with the apnoea-hypopnoea index in patients with obstructive sleep apnea syndrome.
摘要：
目的：检测阻塞性睡眠呼吸暂停综合征患者的视网膜微血管变化。
方法：这种前瞻性，观察性病例对照研究包括健康对照和轻度，中度,和严重的阻塞性睡眠呼吸暂停综合征。血管参数,中央凹无血管区，以黄斑为中心的流动区域，比较扫描尺寸为6.00×6.00mm2的光学相干断层扫描血管造影图像。
结果：对照组整体图像最高，侧腹,浅毛细血管丛和深毛细血管丛各组的中心凹血管密度（均P<0.05）。快速眼动睡眠呼吸暂停-低呼吸指数与整体呈负相关(Rho=-0.195,P=0.034),旁凹（Rho=-0.242，P=0.008），浅毛细血管丛中心凹周围(Rho=-0.187,P=0.045)血管密度,和整体(Rho=-0.186，P=0.046)，旁凹（Rho=-0.260，P=0.004），深毛细血管丛中心凹周围(Rho=-0.189,P=0.043)血管密度,尽管平均和非快速眼动睡眠呼吸暂停-呼吸不足指数仅与浅表毛细血管丛（Rho=-0.213，P=0.020；Rho=-0.191，P=0.038）和深毛细血管丛（Rho=-0.254，P=0.005；Rho=-0.194，P=0.035）的凹旁血管密度有关。
结论：本研究显示阻塞性睡眠呼吸暂停综合征患者血管密度降低及其与呼吸暂停-呼吸低指数的反向相关性。
方法：这种前瞻性，观察性病例对照研究包括健康对照和轻度，中度,和严重的阻塞性睡眠呼吸暂停综合征。血管参数,中央凹无血管区，以黄斑为中心的流动区域，比较扫描尺寸为6.00×6.00mm2的光学相干断层扫描血管造影图像。
结果：对照组整体图像最高，侧腹,浅毛细血管丛和深毛细血管丛各组的中心凹血管密度（均P<0.05）。快速眼动睡眠呼吸暂停-低呼吸指数与整体呈负相关(Rho=-0.195,P=0.034),旁凹（Rho=-0.242，P=0.008），浅毛细血管丛中心凹周围(Rho=-0.187,P=0.045)血管密度,和整体(Rho=-0.186，P=0.046)，旁凹（Rho=-0.260，P=0.004），深毛细血管丛中心凹周围(Rho=-0.189,P=0.043)血管密度,尽管平均和非快速眼动睡眠呼吸暂停-呼吸不足指数仅与浅表毛细血管丛（Rho=-0.213，P=0.020；Rho=-0.191，P=0.038）和深毛细血管丛（Rho=-0.254，P=0.005；Rho=-0.194，P=0.035）的凹旁血管密度有关。
结论：本研究显示阻塞性睡眠呼吸暂停综合征患者血管密度降低及其与呼吸暂停-呼吸低指数的反向相关性。
