评估黄斑和视神经乳头(ONH)血管密度,中央凹无血管区,使用光学相干断层扫描血管造影(OCTA),青少年皮肌炎(JDM)的视网膜和脉络膜毛细血管血流。
本前瞻性研究了10例JDM患者的10只眼睛和15例年龄和性别匹配的健康对照,横断面研究。浅毛细血管丛(SCP)和深毛细血管丛(DCP),ONH,中央凹无血管区(FAZ)参数,外视网膜的流动区域,使用OCTA评估脉络膜毛细血管。
副凹(p=0.036)和副凹次区的血管密度(VD)(对于上半场,p=0.041,下半场p=0.031,对于上级,p=0.012,鼻部p=0.019,劣质的p=0.026,与健康对照组相比,JDM组DCP的时间p=0.048)显着降低。除DCP中的副凹上VD外,疾病持续时间与这些参数之间存在高度负相关。SCP和ONH的VD参数组间无显著差异,FAZ参数,外视网膜,脉络膜毛细血管流面积以及厚度参数。(全部p>0.05)。此外,ROC分析显示,所有副凹DCP参数均显示出良好的区分JDM与健康对照的能力。
我们证明了在JDM的深副凹区域的血管密度降低。因此,我们假设OCTA可以检测没有眼部受累临床证据的JDM患者的视网膜微血管改变.
To evaluate the macular and optic nerve head (ONH) vascular density, foveal avascular zone area, and outer retina and choriocapillaris flow in juvenile dermatomyositis (JDM) using optical coherence tomography angiography (OCTA).
Ten eyes of 10 patients with JDM and 15 age and sex-matched healthy controls were investigated in this prospective, cross-sectional
study. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, foveal avascular zone (FAZ) parameters, the flow area of the outer retina, and choriocapillaris were evaluated using OCTA.
Vessel density (VD) of the parafovea (p = 0.036) and parafoveal subregions (p = 0.041 for superior hemifield, p = 0.031 for inferior hemifield, p = 0.012 for superior, p = 0.019 for nasal, p = 0.026 for inferior, and p = 0.048 for temporal) in DCP were significantly lower in the JDM group compared to healthy controls. A high inverse correlation between disease duration and these parameters was found except parafoveal superior VD in DCP. There was no significant difference between the groups in VD parameters of SCP and ONH, FAZ parameters, outer retina, and choriocapillaris flow area as well as thickness parameters. (p > 0.05 for all). Furthermore, ROC analysis revealed that all parafoveal DCP parameters showed good ability to differentiate JDM from healthy controls.
We demonstrated a decreased vessel density in the deep parafoveal region in JDM. As a result, we hypothesized that OCTA could detect retinal microvascular changes in JDM patients who did not have clinical evidence of ocular involvement.