小核仁RNA(snoRNAs)代表了一类在转录后RNA加工和修饰中起关键作用的非编码RNA,从而显著有助于维持与蛋白质合成相关的细胞功能。已经发现SnoRNA具有影响细胞命运和改变疾病进展的能力。在控制人类疾病方面拥有巨大潜力。这表明snoRNAs在癌症中的失调表现出各种癌症类型的差异表达,阶段,转移,患者的治疗反应和/或预后。另一方面,结直肠癌(CRC),消化系统的恶性肿瘤,其特点是发病率和死亡率高,排名第三的最常见的癌症类型。最近的研究表明,snoRNA失调与CRC有关,因为snoRNA表达在正常和癌性病症之间显著不同。因此,评估snoRNA的表达水平和功能为CRC的预后和诊断提供了希望。然而,目前对snoRNAs在CRC中的潜在作用的理解仍然有限。这篇综述提供了一个全面的调查snoRNAs在CRC中的异常调控,为发现新的生物标志物提供有价值的见解,治疗目标,以及用于诊断和治疗CRC的潜在工具,并为推进CRC研究和明智选择治疗靶标提供关键线索。
Small nucleolar RNAs (snoRNAs) represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification, thereby contributing significantly to the maintenance of cellular functions related to protein synthesis. SnoRNAs have been discovered to possess the ability to influence cell fate and alter disease progression, holding immense potential in controlling human diseases. It is suggested that the
dysregulation of snoRNAs in cancer exhibits differential expression across various cancer types, stages, metastasis, treatment response and/or prognosis in patients. On the other hand, colorectal cancer (CRC), a prevalent malignancy of the digestive system, is characterized by high incidence and mortality rates, ranking as the third most common cancer type. Recent research indicates that snoRNA
dysregulation is associated with CRC, as snoRNA expression significantly differs between normal and cancerous conditions. Consequently, assessing snoRNA expression level and function holds promise for the prognosis and diagnosis of CRC. Nevertheless, current comprehension of the potential roles of snoRNAs in CRC remains limited. This review offers a comprehensive survey of the aberrant regulation of snoRNAs in CRC, providing valuable insights into the discovery of novel biomarkers, therapeutic targets, and potential tools for the diagnosis and treatment of CRC and furnishing critical cues for advancing research into CRC and the judicious selection of therapeutic targets.