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Abstract：
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with a complex pathological mechanism involving autoimmune response, local inflammation and bone destruction. Metabolic pathways play an important role in immune-related diseases and their immune responses. The pathogenesis of rheumatoid arthritis may be related to its metabolic dysregulation. Moreover, histological techniques, including genomics, transcriptomics, proteomics and metabolomics, provide powerful tools for comprehensive analysis of molecular changes in biological systems. The present study explores the molecular and metabolic mechanisms of RA, emphasizing the central role of metabolic dysregulation in the RA disease process and highlighting the complexity of metabolic pathways, particularly metabolic remodeling in synovial tissues and its association with cytokine-mediated inflammation. This paper reveals the potential of histological techniques in identifying metabolically relevant therapeutic targets in RA; specifically, we summarize the genetic basis of RA and the dysregulated metabolic pathways, and explore their functional significance in the context of immune cell activation and differentiation. This study demonstrates the critical role of histological techniques in decoding the complex metabolic network of RA and discusses the integration of histological data with other types of biological data.
摘要：
类风湿性关节炎(RA)是一种慢性炎症性自身免疫性疾病,其病理机制复杂,涉及自身免疫反应,局部炎症和骨破坏。代谢途径在免疫相关疾病及其免疫反应中起重要作用。类风湿关节炎的发病机制可能与其代谢失调有关。此外，组织学技术，包括基因组学，转录组学，蛋白质组学和代谢组学，为全面分析生物系统中的分子变化提供强大的工具。本研究探讨了RA的分子和代谢机制，强调代谢失调在RA疾病过程中的核心作用，并强调代谢途径的复杂性，特别是滑膜组织的代谢重塑及其与细胞因子介导的炎症的关系。本文揭示了组织学技术在确定RA代谢相关治疗靶标方面的潜力；特别是，我们总结了RA的遗传基础和失调的代谢途径，并探讨其在免疫细胞活化和分化中的功能意义。这项研究证明了组织学技术在解码RA复杂代谢网络中的关键作用，并讨论了组织学数据与其他类型生物学数据的整合。
