PDF(Pubmed)
Abstract：
Protein methylation, similar to DNA methylation, primarily involves post-translational modification (PTM) targeting residues of nitrogen-containing side-chains and other residues. Protein arginine methylation, occurred on arginine residue, is mainly mediated by protein arginine methyltransferases (PRMTs), which are ubiquitously present in a multitude of organisms and are intricately involved in the regulation of numerous biological processes. Specifically, PRMTs are pivotal in the process of gene transcription regulation, and protein function modulation. Abnormal arginine methylation, particularly in histones, can induce dysregulation of gene expression, thereby leading to the development of cancer. The recent advancements in modification mediated by PRMTs and cancer research have had a profound impact on our understanding of the abnormal modification involved in carcinogenesis and progression. This review will provide a defined overview of these recent progression, with the aim of augmenting our knowledge on the role of PRMTs in progression and their potential application in cancer therapy.
摘要：
蛋白质甲基化，类似于DNA甲基化，主要涉及靶向含氮侧链的残基和其他残基的翻译后修饰(PTM)。蛋白质精氨酸甲基化，发生在精氨酸残留物上，主要由蛋白质精氨酸甲基转移酶（PRMTs）介导，它们普遍存在于许多生物体中，并且错综复杂地参与许多生物过程的调节。具体来说,PRMT是基因转录调控过程中的关键,和蛋白质功能调节。异常精氨酸甲基化，特别是在组蛋白中，可以诱导基因表达失调，从而导致癌症的发展。PRMT介导的修饰和癌症研究的最新进展对我们对癌症发生和进展中异常修饰的理解产生了深远的影响。这篇综述将提供这些最新进展的明确概述，目的是增加我们对PRMT在进展中的作用及其在癌症治疗中的潜在应用的认识。
