PDF(Pubmed)
Abstract：
Iron metabolism plays a crucial role in various physiological functions of the human body, as it is essential for the growth and development of almost all organisms. Dysregulated iron metabolism-manifested either as iron deficiency or overload-is a significant risk factor for the development of cardiovascular disease (CVD). Moreover, emerging evidence suggests that ferroptosis, a form of iron-dependent programed cell death, may also contribute to CVD development. Understanding the regulatory mechanisms of iron metabolism and ferroptosis in CVD is important for improving disease management. By integrating different perspectives and expertise in the field of CVD-related iron metabolism, this overview provides insights into iron metabolism and CVD, along with approaches for diagnosing, treating, and preventing CVD associated with iron dysregulation.
摘要：
铁代谢在人体的各种生理功能中起着至关重要的作用，因为它对几乎所有生物的生长和发育都至关重要。铁代谢失调-表现为铁缺乏或超负荷-是心血管疾病（CVD）发展的重要危险因素。此外，新出现的证据表明铁性死亡，一种依赖铁的程序性细胞死亡，也可能有助于CVD的发展。了解CVD中铁代谢和铁凋亡的调节机制对于改善疾病管理很重要。通过整合CVD相关铁代谢领域的不同观点和专业知识，本概述提供了有关铁代谢和CVD的见解，以及诊断方法，治疗,并预防与铁失调相关的CVD。
