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Abstract：
As a novel post-translational modification of proteins, succinylation is widely present in both prokaryotes and eukaryotes. By regulating protein translocation and activity, particularly involved in regulation of gene expression, succinylation actively participates in diverse biological processes such as cell proliferation, differentiation and metabolism. Dysregulation of succinylation is closely related to many diseases. Consequently, it has increasingly attracted attention from basic and clinical researchers. For a thorough understanding of succinylation dysregulation and its implications for disease development, such as inflammation, tumors, cardiovascular and neurological diseases, this paper provides a comprehensive review of the research progress on abnormal succinylation. This understanding of association of dysregulation of succinylation with pathological processes will provide valuable directions for disease prevention/treatment strategies as well as drug development.
摘要：
作为一种新型的蛋白质翻译后修饰,琥珀酰化广泛存在于原核生物和真核生物中。通过调节蛋白质的转运和活性，特别是参与基因表达的调节，琥珀酰化积极参与各种生物过程，如细胞增殖，分化和新陈代谢。琥珀酰化失调与许多疾病密切相关。因此,越来越受到基础和临床研究者的关注。为了彻底了解琥珀酰化失调及其对疾病发展的影响，比如炎症，肿瘤，心血管和神经系统疾病，本文就琥珀酰化异常的研究进展作一综述。这种对琥珀酰化失调与病理过程关联的理解将为疾病预防/治疗策略以及药物开发提供有价值的方向。
