目标:种植体周围疾病,是最常见的植入物相关并发症,显著影响植入物的正常功能和寿命。实验模型在发现潜在的治疗方法和阐明植入物周围疾病的疾病进展机制中起着至关重要的作用。这篇叙述性综述全面考察了种植体周围疾病研究中采用的动物模型和常用建模方法,并创新性地总结了种植体周围疾病的体外模型。
方法:从PubMed/Medline检索了2015年至2023年之间发表的文章,WebofScience,和Embase。所有专注于种植体周围疾病实验模型的研究都被纳入并仔细评估。
结果:种植体周围炎的各种实验模型具有不同的应用和优势。犬模型是目前种植体周围疾病研究中应用最广泛的动物模型,而啮齿动物模型在基因敲除和全身性疾病诱导方面具有独特的优势。种植体周围疾病的体外模型也在不断发展以满足不同的实验目的。
结论:实验模型的使用有助于简化实验,节省时间和资源,促进种植体周围疾病研究的进展。动物模型在药物开发的早期阶段已经被证明是有价值的,而技术进步带来了更具预测性和相关性的体外模型。
结论:这篇综述为种植体周围疾病领域的研究人员提供了清晰而全面的模型选择策略,从而增强对疾病发病机制的理解,并为开发新的治疗策略提供可能。
OBJECTIVE: Peri-implant diseases, being the most common implant-related complications, significantly impact the normal functioning and longevity of implants. Experimental models play a crucial role in discovering potential therapeutic approaches and elucidating the mechanisms of disease progression in peri-implant diseases. This narrative
review comprehensively examines animal models and common modeling methods employed in peri-implant disease research and innovatively summarizes the in vitro models of peri-implant diseases.
METHODS: Articles published between 2015 and 2023 were retrieved from PubMed/Medline, Web of Science, and Embase. All studies focusing on experimental models of peri-implant diseases were included and carefully evaluated.
RESULTS: Various experimental models of peri-implantitis have different applications and advantages. The dog model is currently the most widely utilized animal model in peri-implant disease research, while rodent models have unique advantages in gene knockout and systemic disease induction. In vitro models of peri-implant diseases are also continuously evolving to meet different experimental purposes.
CONCLUSIONS: The utilization of experimental models helps simplify experiments, save time and resources, and promote advances in peri-implant disease research. Animal models have been proven valuable in the early stages of drug development, while technological advancements have brought about more predictive and relevant in vitro models.
CONCLUSIONS: This
review provides clear and comprehensive model selection strategies for researchers in the field of peri-implant diseases, thereby enhancing understanding of disease pathogenesis and providing possibilities for developing new treatment strategies.