Abstract：
Spinal cord injury (SCI) is a serious medical condition. The search for an effective cure remains a persistent challenge. Current treatments, unfortunately, are unable to sufficiently improve neurological function, often leading to lifelong disability. This systematic review and meta-analysis evaluated the effectiveness of stem cell therapy for SCI using canine models. It also explored the optimal protocol for implementing stem cell therapy. A comprehensive search of studies was conducted from 2000 to October 2022. This study focused on five outcomes: motor function score, histopathology, IHC, western blot, and SEP. The results demonstrated a significant improvement in locomotion post-SCI in dogs treated with stem cell therapy. The therapy also led to an average increase of 3.15 points in the Olby score of the treated dogs compared to the control group. These findings highlights stem cell therapy\'s potential as a promising SCI treatment. The meta-analysis suggests that using bone marrow stem cells, undergoing neural differentiation in vitro, applying a surgical implantation or intrathecal route of administration, associating matrigel in combination with stem cells, and a waiting period of two weeks before starting treatment can enhance SCI treatment effectiveness.
摘要：
脊髓损伤（SCI）是一种严重的医学疾病。寻找有效的治疗方法仍然是一个持续的挑战。目前的治疗方法,不幸的是,无法充分改善神经功能，往往导致终身残疾。本系统综述和荟萃分析使用犬模型评估干细胞治疗SCI的有效性。它还探索了实施干细胞治疗的最佳方案。从2000年到2022年10月进行了全面的研究搜索。这项研究集中在五个结果：运动功能评分，组织病理学,IHC,westernblot,和SEP。结果表明，在接受干细胞治疗的狗中，SCI后的运动得到了显着改善。与对照组相比,该疗法还导致治疗的狗的Olby评分平均增加3.15分。这些发现凸显了干细胞治疗作为一种有前途的SCI治疗的潜力。荟萃分析表明，使用骨髓干细胞，在体外进行神经分化，应用手术植入或鞘内给药途径，将基质胶与干细胞结合起来，在开始治疗前等待两周可以提高SCI治疗的有效性。
