Abstract：
Chronic kidney disease (CKD) and acute kidney injury (AKI) are diseases which affect the urinary tract characterized by the loss of renal function. Their therapy requires different therapeutic goals. Mesenchymal stem cells (MSC) transplantation has spread over the years as a treatment for many diseases. In the urinary tract, studies report anti-inflammatory, antiapoptotic, antifibrotic, antioxidant and angiogenic effects. This work reports the results of a meta-analysis about the effects of the MSC application in serum levels of creatinine in dogs and cats with AKI and CKD. The work followed PRISMA guidelines. Data were screened, selected, and extracted with characteristics about the studies. The kinds of injury were classified according to their identification and the risk of bias was calculated by the system SYRCLE. The results of each group were combined by the inverse variance method. The heterogeneity was evaluated by the I2 test. For the mean of creatinine, a meta-analysis was performed according to the study group and number of applications and separately for the control and treatment groups according to the kind of injury, dose, application route, and moment. At all, 4742 articles were found. Of these, 40 were selected for eligibility, 16 underwent qualitative analysis and 9 to the quantitative. The results denote advantage to the group treated with MSC over placebo. A statistical difference was observed both in combined analysis and in the subgroups division. However, a high heterogeneity was found, which indicates considerable variation between the studies, which indicates caution in generalize the results.
摘要：
慢性肾脏病（CKD）和急性肾损伤（AKI）是以肾功能丧失为特征的尿路疾病。他们的治疗需要不同的治疗目标。间充质干细胞(MSC)移植多年来作为许多疾病的治疗方法已经传播。在泌尿道，研究报告抗炎，抗凋亡，抗纤维化,抗氧化和血管生成作用。这项工作报告了关于MSC应用对患有AKI和CKD的狗和猫的血清肌酐水平的影响的荟萃分析结果。这项工作遵循了PRISMA准则。对数据进行了筛选，选定,并提取了有关研究的特征。根据鉴定对损伤的种类进行分类，并通过系统SYRCLE计算偏倚风险。通过逆方差法合并各组的结果。通过I2检验评价异质性。肌酐的平均值，根据研究组和应用数量进行荟萃分析，根据损伤的种类分别对对照组和治疗组进行荟萃分析，剂量,申请路线,和时刻。总之,找到4742篇文章。其中,40人入选资格，16进行了定性分析，9进行了定量。结果表明用MSC治疗的组优于安慰剂。在组合分析和亚组划分中均观察到统计学差异。然而,发现了高度的异质性，这表明研究之间存在相当大的差异，这表明在推广结果时要谨慎。
