严重的肛门上皮内鳞状病变在与男性发生性关系并感染人类免疫缺陷病毒的男性中非常普遍。这种情况-肛门癌的先兆-显着增加了发展它的风险。相反,低度肛门上皮内鳞状通常遵循良性病程,通常自发消退。
方法:为了描述与患有人类免疫缺陷病毒的男性发生性关系的男性人群,我们在专门的肛门癌筛查单元中进行了观察,回顾性,单中心研究是。
结果:分析了94例患者,平均年龄39±9岁,高危型人乳头瘤病毒(HR-HPV)阳性率为87%。在初次访问时,47%表现为低度鳞状上皮内病变。高度鳞状上皮内病变的进展率为37.2/100,000患者/年。没有患者发生肛门癌。烟草和酒精消费与这一进展有关。
结论:在本系列中,艾滋病毒感染的持续时间更长,烟草和酒精的使用以及HR-HPV的存在与高级别上皮内病变的发生显著相关.在受过高等教育的患者中,进展风险较低。
结论:在与感染艾滋病毒的男性发生性关系的男性中,吸烟等因素的关联,酒精,HR-HPV的存在和人乳头瘤病毒疾病负担的增加使得这些患者更容易发生高度肛门鳞状病变.
High-grade anal intraepithelial squamous lesion is significantly prevalent among men who have sex with men and are infected with the human immunodeficiency virus. This condition-the precursor to anal cancer-significantly increases the risk of developing it. Conversely, low-grade anal intraepithelial squamous typically follow a benign course and usually regress spontaneously.
METHODS: To describe a population of men who have sex with men living with human immunodeficiency virus followed in a specialized anal cancer screening unit we conducted an observational, retrospective, and single-center study was.
RESULTS: Ninety-four patients were analyzed, with a mean age of 39 ± 9 years, and a 87% positivity rate for high-risk human papillomavirus (HR-HPV). At the initial visit, 47% presented with low-grade squamous intraepithelial lesions. The progression rate to high-grade squamous intraepithelial lesion was 37.2 per 100,000 patients/year. None of the patients developed anal cancer. Tobacco and alcohol consumption were associated with this progression.
CONCLUSIONS: In this series, longer duration of HIV infection, tobacco and alcohol use and the presence of HR-HPV were significantly associated with the occurrence of high-grade intraepithelial lesions. A lower risk of progression was seen in patients with higher education.
CONCLUSIONS: In men who have sex with men living with HIV, the association of factors such as smoking, alcohol, the presence of HR-HPV and an increased burden of human papillomavirus disease makes these patients more susceptible to develop high-grade anal squamous lesions.