%0 Journal Article
%T Retrospective study of risk markers for developing high-grade anal intraepithelial neoplasm in men who have sex with men living with HIV.
%A Feltes Ochoa RA
%A Sendagorta Cudos E
%A Álvarez Gallego M
%A Pérez-Ramos L
%A Herranz Pinto P
%J Actas Dermosifiliogr
%V 0
%N 0
%D 2024 Jul 18
%M 39032782
暂无%R 10.1016/j.ad.2024.05.026
%X High-grade anal intraepithelial squamous lesion is significantly prevalent among men who have sex with men and are infected with the human immunodeficiency virus. This condition-the precursor to anal cancer-significantly increases the risk of developing it. Conversely, low-grade anal intraepithelial squamous typically follow a benign course and usually regress spontaneously.<BR><B>METHODS: </B>To describe a population of men who have sex with men living with human immunodeficiency virus followed in a specialized anal cancer screening unit we conducted an observational, retrospective, and single-center study was.<BR><B>RESULTS: </B>Ninety-four patients were analyzed, with a mean age of 39 ± 9 years, and a 87% positivity rate for high-risk human papillomavirus (HR-HPV). At the initial visit, 47% presented with low-grade squamous intraepithelial lesions. The progression rate to high-grade squamous intraepithelial lesion was 37.2 per 100,000 patients/year. None of the patients developed anal cancer. Tobacco and alcohol consumption were associated with this progression.<BR><B>CONCLUSIONS: </B>In this series, longer duration of HIV infection, tobacco and alcohol use and the presence of HR-HPV were significantly associated with the occurrence of high-grade intraepithelial lesions. A lower risk of progression was seen in patients with higher education.<BR><B>CONCLUSIONS: </B>In men who have sex with men living with HIV, the association of factors such as smoking, alcohol, the presence of HR-HPV and an increased burden of human papillomavirus disease makes these patients more susceptible to develop high-grade anal squamous lesions.