PDF(Pubmed)
Abstract：
Epidemiological studies have shown that HPV-related diseases are the most prevalent sexually transmitted infections. In this context, this report will present various clinical cases demonstrating the effectiveness of Acyclovir (ACV) or its prodrug Valaciclovir (VCV), both acyclic guanosine analogs commonly used for the treatment of HHV-1 and HHV-2, for the treatment of HPV-related diseases. The report shows the remission of five cases of penile condyloma and a case of remission in a woman affected by cervical and vaginal condylomas and a vulvar giant condyloma acuminate of Buschke and Lowenstein. The literature review shows that ACV is effective in treating skin warts when administered orally, topically, and intralesionally, suggesting its therapeutic potential in other diseases associated with HPV. ACV was also used successfully as an adjuvant therapy for juvenile and adult forms of laryngeal papillomatosis, also known as recurrent respiratory papillomatosis, prolonging the patient\'s symptom-free periods. Although the prevention of HPV infections is certainly achieved with the HPV vaccine, ACV and VCV have shown to be effective even against genotypes not included in the current vaccine and can be helpful for those problematic clinical cases involving unvaccinated individuals, immunocompromised patients, people who live with HIV, or non-responders to the vaccine. We and others concluded that randomized clinical trials are necessary to determine the efficacy of ACV and VCV for HPV-related diseases.
摘要：
流行病学研究表明，HPV相关疾病是最常见的性传播感染。在这种情况下，本报告将介绍各种临床病例，证明阿昔洛韦（ACV）或其前药伐昔洛韦（VCV）的有效性，两种无环鸟苷类似物通常用于治疗HHV-1和HHV-2,用于治疗HPV相关疾病。该报告显示了5例阴茎尖锐湿疣的缓解和1例受宫颈和阴道尖锐湿疣以及Buschke和Lowenstein的外阴巨大尖锐湿疣的缓解。文献综述显示ACV口服治疗皮肤疣有效,局部，在内部，提示其在与HPV相关的其他疾病中的治疗潜力。ACV还成功地用作青少年和成人形式的喉乳头状瘤病的辅助治疗。也被称为复发性呼吸道乳头状瘤病，延长患者的无症状期。尽管HPV疫苗肯定可以预防HPV感染，ACV和VCV已被证明甚至对当前疫苗中未包括的基因型有效，并且可以对那些涉及未接种疫苗的个体的有问题的临床病例有所帮助。免疫力低下的患者，艾滋病毒携带者，或对疫苗无反应者。我们和其他人得出结论，需要进行随机临床试验来确定ACV和VCV对HPV相关疾病的疗效。
