人乳头瘤病毒(HPV)相关的良性乳头状上皮肿瘤是影响口腔任何区域的常见病变。这项研究评估了频率的趋势,location,在大型活检服务中,这些病变的人口统计学超过20年。IRB批准后,查询了1995年至2015年UF口腔病理活检服务的档案.诊断为鳞状乳头状瘤的病例,寻常疣,包括尖锐湿疣。口外位置,不确定的诊断,或综合征相关的HPV病变被排除.年龄,性别,location,临床表现,并记录诊断。评估了每5年一个日历年的数据,包括1995年、2000年、2005年、2010年和2015年。在评估的总共5个日历年中,共发现了1458例病例。乳头状瘤占每年活检总数的百分比如下:1995年(2.6%),2000年(3.3%),2005年(3.6%),2010年(4.0%)和2015年(4.5%),代表73%(1.9×)的百分比增加。男性(56%)受影响更常见;然而,在19岁以下的患者中,观察到女性占主导地位。在整个时间段内,女性的总体病变百分比增加了30.6%。平均年龄为54岁(范围1-93岁),随着时间的推移增加了10岁。约1.1%的患者多灶性病变,0.2%的患者复发。按照频率的降序,舌头,软腭,下颌牙龈受累最多。上颌牙龈和下唇是19岁以下患者中最常见的位置。位置随时间变化,然而,最大的增加是牙龈病变。鳞状乳头状瘤是最常见的组织学变异(93.6%)。在研究的20年中,良性HPV相关口腔病变的发生率大大增加。这种增加是统计学上显著的,p值<0.00045。注意到的其他趋势包括以下方面的增加:平均年龄,女性参与,和牙龈位置。我们的结果表明,我们人群中良性口腔HPV病变的患病率总体上升的趋势。
Human papillomavirus (HPV)-related benign papillary epithelial neoplasms are common lesions affecting any region of the oral cavity. This study evaluated the trends in frequency, location, and demographics of these lesions over 20 years in a large biopsy service. Following IRB approval, the archives of UF Oral Pathology Biopsy Service between 1995 and 2015 were queried. Cases diagnosed as squamous papilloma, verruca vulgaris, and
condyloma acuminatum were included. Extraoral locations, inconclusive diagnoses, or syndrome-related HPV lesions were excluded. Age, gender, location, clinical presentation, and diagnoses were recorded. Data from one calendar year per 5-year span was assessed including the years 1995, 2000, 2005, 2010, and 2015. A total of 1458 cases were identified over the total 5 calendar years assessed. Papilloma as a percentage of total biopsies per year was as follows: 1995 (2.6%), 2000 (3.3%), 2005 (3.6%), 2010 (4.0%) and 2015 (4.5%), representing a 73% (1.9×) percentage increase. Males (56%) were affected more commonly; however, in patients under 19 years, a female predominance was observed. The overall percentage of lesions in females increased by 30.6% over the time frame. The mean age was 54 years (range 1-93 years) with an increase of 10 years over time. About 1.1% of patients had multifocal lesions and 0.2% had a recurrence. In descending order of frequency, the tongue, soft palate, and mandibular gingiva were most involved. Maxillary gingiva and lower lip were the most common locations in patients under 19. Location varied over time, however, the biggest increase was noted for lesions on the gingiva. Squamous papilloma was the most common histologic variant (93.6%). The incidence of benign HPV-related oral lesions increased substantially over the 2 decades studied. This increase was statistically significant with a p-value <0.00045. Other trends noted included increase in the following: the average age, female involvement, and gingival location. Our results indicate a trend for the overall increase in the prevalence of benign oral HPV lesions in our population.