UNASSIGNED: Cross-sectional study among eligible patients seen at the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center (2016-2023) (n = 920). Sociodemographic and clinical variables were collected from medical records. Patients underwent a high-resolution anoscopy (HRA) during the clinical visit; physicians assessed anal condylomas on HRA. Poisson regression models with robust standard errors were used to evaluate the association between smoking and anal warts. Demographic and clinical factors were also assessed.
UNASSIGNED: The mean age of participants was 45.8 ± 13.1 years, 66.4 % were men, and 21.6 % were current smokers. While 10.8 % self-reported a history of anogenital condylomas, 18.9 % had anal condylomas on clinical evaluation. A higher prevalence of anal condylomas was observed among current smokers (PR = 1.28, 95 % CI: 0.94-1.75) in comparison to non-smokers in adjusted analysis, but this was not statistically significant. However, a higher prevalence of anal condylomas was observed among younger individuals (PR = 0.96, 95 % CI: 0.96-0.98) and individuals with anal high-grade squamous intraepithelial lesions (HSIL) as compared to those with benign histology (PR = 1.74. 95 % CI: 1.09-2.77).
UNASSIGNED: Although current smoking seemed to be positively associated with anal condylomas in this high-risk Hispanic population, this finding was not statistically significant as the power to detect an association was limited. However, younger age and HSIL diagnosis were associated with a higher prevalence of anal condylomas.
■在波多黎各大学综合癌症中心肛门瘤变诊所(2016-2023年)(n=920)看到的符合条件的患者中进行的横断面研究。从医疗记录中收集社会人口统计学和临床变量。在临床访问期间,患者接受了高分辨率肛门镜检查(HRA);医生评估了HRA的肛门尖锐湿疣。使用具有稳健标准误差的泊松回归模型来评估吸烟与肛门疣之间的关联。还评估了人口统计学和临床因素。
■参与者的平均年龄为45.8±13.1岁,66.4%是男性,21.6%是目前的吸烟者。虽然10.8%的人自我报告有肛门生殖器尖锐湿疣的病史,经临床评估,18.9%有肛门尖锐湿疣。在调整分析中,与不吸烟者相比,目前吸烟者的肛门尖锐湿疣患病率更高(PR=1.28,95%CI:0.94-1.75)。但这没有统计学意义。然而,与良性组织学患者相比,在年轻个体(PR=0.96,95%CI:0.96~0.98)和肛门高级别鳞状上皮内病变(HSIL)个体中,肛门尖锐湿疣的患病率较高(PR=1.74.95%CI:1.09-2.77)。
尽管目前吸烟似乎与高危西班牙裔人群的肛门尖锐湿疣呈正相关,这一发现没有统计学意义,因为检测关联的能力有限.然而,年龄和HSIL诊断与肛门尖锐湿疣的患病率较高相关.