PDF(Pubmed)
Abstract：
Human papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV oncogenesis is due to the ability of the viral oncoproteins E6 and E7 to alter the control mechanisms for the growth and proliferation of host cell. Therefore, the use of agents with the ability to control these processes is essential in the search for effective treatments against HPV infections. Glycyrrhizinic acid (Gly), the active ingredient in liquorice, has been shown in numerous preclinical studies to have an antiviral and anticancer activity, reducing the expression of E6 and E7 and inducing apoptosis in cervical cancer cells. In addition, it also has antioxidant, anti-inflammatory, immunomodulatory or re-epithelializing properties that can be useful in HPV infections. This review includes the different antiviral and anticancer mechanisms described for Gly, as well as the clinical studies carried out that position it as a potential therapeutic strategy against HPV both through its topical application and by oral administration.
摘要：
人乳头瘤病毒(HPV),和其他病毒一样,需要穿透宿主细胞并利用其机器进行复制。从那里,HPV感染可以无症状或导致良性和癌前病变甚至不同类型的癌症。HPV肿瘤发生是由于病毒癌蛋白E6和E7改变宿主细胞生长和增殖的控制机制的能力。因此,在寻找针对HPV感染的有效治疗方法中,使用能够控制这些过程的药物是必不可少的.甘草酸(Gly),甘草中的活性成分，已在许多临床前研究中显示具有抗病毒和抗癌活性，降低E6和E7的表达并诱导宫颈癌细胞凋亡。此外,它还具有抗氧化剂，抗炎,可用于HPV感染的免疫调节或再上皮化特性。这篇综述包括Gly描述的不同的抗病毒和抗癌机制，以及通过局部应用和口服给药将其定位为针对HPV的潜在治疗策略的临床研究。
