Radiation Exposure

辐射暴露
  • 文章类型: Systematic Review
    背景:在腔内泌尿外科手术期间每天使用电离辐射。尽管辐射的确定性和随机效应都有危险,泌尿科医生缺乏知识和意识。这项研究回顾了文献,以确定泌尿科医师在腔内手术期间的辐射暴露(RE)。
    方法:Medline的文献检索,WebofScience,和GoogleScholar数据库进行收集与泌尿科医师在腔内手术期间的辐射剂量相关的文章。共筛选了1966篇文章。21份出版物使用PRIMA标准符合纳入标准。
    结果:纳入21项研究,其中14个是前瞻性的。在研究之间,泌尿科医师的平均RE差异很大。PCNL对泌尿科医生的RE最高,尤其是俯卧位.在俯卧的PCNL中,眼睛和手的RE最高,与仰卧PCNL相比。佩戴甲状腺护罩和铅围裙可使RE降低94.1%至100%。关于辐射可能危险的教育课程减少了RE,并提高了内藏学家的认识。
    结论:这是40多年来对泌尿科医师进行RE分析的文献中的第一个系统综述。穿着防护服,如铅眼镜,甲状腺护盾,铅围裙对于保护泌尿科医生免受辐射至关重要。应鼓励辐射教育课程,进一步减少可再生能源,提高对辐射有害影响的认识,因为目前内脏学家的意识很低。
    BACKGROUND: Ionizing radiation is used daily during endourological procedures. Despite the dangers of both deterministic and stochastic effects of radiation, there is a lack of knowledge and awareness among urologists. This study reviewed the literature to identify the radiation exposure (RE) of urologists during endourological procedures.
    METHODS: A literature search of the Medline, Web of Science, and Google Scholar databases was conducted to collect articles related to the radiation dose to urologists during endourological procedures. A total of 1966 articles were screened. 21 publications met the inclusion criteria using the PRIMA standards.
    RESULTS: Twenty-one studies were included, of which 14 were prospective. There was a large variation in the mean RE to the urologist between studies. PCNL had the highest RE to the urologist, especially in the prone position. RE to the eyes and hands was highest in prone PCNL, compared to supine PCNL. Wearing a thyroid shield and lead apron resulted in a reduction of RE ranging between 94.1 and 100%. Educational courses about the possible dangers of radiation decreased RE and increased awareness among endourologists.
    CONCLUSIONS: This is the first systematic review in the literature analyzing RE to urologists over a time period of more than four decades. Wearing protective garments such as lead glasses, a thyroid shield, and a lead apron are essential to protect the urologist from radiation. Educational courses on radiation should be encouraged to further reduce RE and increase awareness on the harmful effects of radiation, as the awareness of endourologists is currently very low.
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  • 文章类型: Journal Article
    背景/目标:口腔成像技术的进步正在不断塑造牙科诊断和治疗计划的格局。其中,光子计数计算机断层扫描(PCCT),在2021年推出,已经成为一个有希望的,高质量的口腔技术。牙科成像通常需要超过使用专用锥束CT可实现的标准CT系统的分辨率。PCCT可以提供高达100μm的分辨率,改善软组织对比度,并提供更快的扫描时间,这对于详细的牙科诊断和治疗计划至关重要。使用半导体探测器,PCCT可产生更清晰的图像,并有可能减少所需的扫描次数,从而减少患者的辐射暴露。本文旨在探讨PCCT在牙科成像中的潜在益处。方法:对2010年1月至2024年2月文献中PCCT在牙科影像学中的应用进行分析,Scopus,和WebofScience数据库,专注于高分辨率,患者安全,以及牙科结构评估中的诊断效率。我们包括英语文章,案例研究,信件,观察性研究,和随机对照试验,同时排除与PCCT在牙科成像中的应用无关的重复和研究。结果:研究突出了PCCT在减少伪影方面的优越性,这往往是有问题的,与传统的CBCT和传统的CT扫描相比,由于金属牙科植入物,特别是当与虚拟单能量成像和迭代金属伪影减少一起使用时,从而改善植入物成像。这篇评论承认局限性,例如忽视其他先进成像技术的潜力,一个狭窄的研究时间框架,缺乏该领域的实际临床应用数据,和成本。结论:PCCT代表了牙科影像学的一个有希望的进步,提供高分辨率的视觉效果,增强对比度,和快速扫描减少辐射暴露。
    Background/Objectives: Advancements in oral imaging technology are continually shaping the landscape of dental diagnosis and treatment planning. Among these, photon-counting computed tomography (PCCT), introduced in 2021, has emerged as a promising, high-quality oral technology. Dental imaging typically requires a resolution beyond the standard CT systems achievable with the specialized cone-beam CT. PCCT can offer up to 100 µm resolution, improve soft-tissue contrast, and provide faster scanning times, which are crucial for detailed dental diagnosis and treatment planning. Using semiconductor detectors, PCCT produces sharper images and can potentially reduce the number of scans required, thereby decreasing patient radiation exposure. This review aimed to explore the potential benefits of PCCT in dental imaging. Methods: This review analyzed the literature on PCCT in dental imaging from January 2010 to February 2024, sourced from PubMed, Scopus, and Web of Science databases, focusing on high-resolution, patient safety, and diagnostic efficiency in dental structure assessment. We included English-language articles, case studies, letters, observational studies, and randomized controlled trials while excluding duplicates and studies unrelated to PCCT\'s application in dental imaging. Results: Studies have highlighted the superiority of PCCT in reducing artifacts, which are often problematic, compared to conventional CBCT and traditional CT scans, due to metallic dental implants, particularly when used with virtual monoenergetic imaging and iterative metal artifact reduction, thereby improving implant imaging. This review acknowledges limitations, such as the potential for overlooking other advanced imaging technologies, a narrow study timeframe, the lack of real-world clinical application data in this field, and costs. Conclusions: PCCT represents a promising advancement in dental imaging, offering high-resolution visuals, enhanced contrast, and rapid scanning with reduced radiation exposure.
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  • 文章类型: Journal Article
    背景:在超声不确定的情况下,计算机断层扫描(CT)成像用于评估小儿尿石症。由于癌症发展的风险增加,必须考虑CT成像的实用性以及该患者人群中辐射暴露的潜在风险。这篇评论的目的是研究与标准剂量和低剂量计算机断层扫描(CT)成像相关的辐射暴露,以评估小儿尿石症。
    方法:对2000年至2023年的23年期间的所有英语研究进行了范围界定文献综述,报告使用非造影CT成像评估小儿尿石症。包括在干预时年龄≤20岁并接受标准剂量或低/超低剂量CT的儿童患者。低剂量和超低剂量CT定义为辐射剂量≤3.0mSv和≤1.9mSv,分别。
    结果:共鉴定出8121篇文章,经过筛选,本范围审查包括6篇代表309名患者的文章。在审查的文章中,儿童尿石症评估的标准非对比CT辐射剂量为2.9~5.5mSv,低剂量CT辐射剂量为1.0~2.72mSv.与标准剂量CT成像相比,只有2项研究直接评估了低剂量CT成像对小儿尿石症的评估。在所审查的2项研究中,减少辐射的方法并未对尿石症的检测或表征产生负面影响。
    结论:疑似或已知小儿尿石症的CT辐射剂量被低估,并且随着低剂量/超剂量方案对小儿尿石症的利用不足,差异很大,尤其是与成年人相比。这项范围审查的结果支持,针对小儿结石疾病的低剂量CT方案对于减少辐射暴露是可行的。
    BACKGROUND: Computed tomography (CT) imaging is used for assessment of pediatric urolithiasis in cases where ultrasound is inconclusive. The utility of CT imaging must be considered alongside the potential risks of radiation exposure in this patient population due to the increased risk of cancer development. The purpose of this review is to investigate the radiation exposure associated with standard-dose and low-dose computed tomography (CT) imaging for the assessment of pediatric urolithiasis.
    METHODS: A scoping literature review over a 23 year period between 2000 and 2023 was conducted of all English-language studies reporting on the use of non-contrast CT imaging for assessment of pediatric urolithiasis. Patients that were specified as pediatric with age ≤20 years at time of intervention and undergoing standard-dose or low/ultra-low-dose CT were included. Low-dose and ultra-low-dose CT were defined as a radiation dose ≤3.0 mSv and ≤1.9 mSv, respectively.
    RESULTS: A total of 8121 articles were identified and after screening, 6 articles representing 309 patients were included in this scoping review. Of the articles reviewed, standard non-contrast CT radiation doses for pediatric urolithiasis evaluation ranged from 2.9 to 5.5 mSv and low-dose CT radiation dose was reported to be 1.0-2.72 mSv. Only 2 studies directly evaluated low-dose CT imaging compared to standard-dose CT imaging for pediatric urolithiasis assessment. Radiation reduction approaches did not negatively impact urolithiasis detection or characterization in 2 studies reviewed.
    CONCLUSIONS: CT radiation doses for suspected or known pediatric urolithiasis are underreported and vary greatly with underutilization of low-dose/ultra-dose protocols for pediatric urolithiasis especially in comparison to the adult population. Results from this scoping review support that low-dose CTprotocols for pediatric stone disease are feasible to reduce radiation exposure.
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  • 文章类型: Journal Article
    视网膜母细胞瘤是儿童最常见的眼部恶性肿瘤,如果不及时治疗可侵入眼内结构,转移,很少导致死亡。传统上接受全身化疗,动脉内化疗越来越受欢迎,因为它允许通过眼动脉直接进行化疗,从而减少全身副作用。动脉内化疗程序已经发展,进行改进以减少风险和辐射暴露。即使在晚期病例中,动脉内化疗也具有令人印象深刻的技术成功率和一年的眼生存率。这篇综述提供了对该技术的彻底检查,适应症,禁忌症,结果,和动脉内化疗的替代选择。
    Retinoblastoma is the most common eye malignancy in children that if left untreated can invade intraocular structures, metastasize, and rarely lead to death. Traditionally treated with systemic chemotherapy, Intra-arterial chemotherapy is gaining popularity as it allows for the direct administration of chemotherapy through the ophthalmic artery, thus reducing systemic side effects. Intra-arterial chemotherapy procedures have evolved, with refinements to reduce risks and radiation exposure. Intra-arterial chemotherapy boasts an impressive technical success rate and one year ocular survival even amongst advanced cases. This review offers a thorough examination of the technique, indications, contraindications, outcomes, and alternative options for Intra-arterial chemotherapy.
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  • DOI:
    文章类型: Systematic Review
    背景:每年进行数以百万计的介入疼痛程序来解决慢性疼痛。这些程序的增加也引起了对进行荧光透视引导手术的介入疼痛管理医师与电离辐射相关的健康风险的关注。一些健康问题包括癌症,白内障,甚至怀孕异常。关于小辐射剂量的长期和累积影响知之甚少。
    目的:本系统评价的目的是确定在介入疼痛过程中暴露于电离辐射的常见身体部位,并研究帮助医生减少辐射暴露的方法。
    方法:使用系统评价和Meta分析(PRISMA)检查表的首选报告项目对来自2个医学数据库的文章进行综合鉴定。从相关同行评审的文章中获得的对介入疼痛管理医师的辐射剂量进行汇总并用于分析。
    方法:PubMed首次用于收集“辐射暴露疼痛管理”和“辐射暴露干预学家”两个广泛关键词搜索的文章,年份从1956年到2023年2月。EMBASE还用于收集“辐射暴露疼痛管理”和“辐射暴露干预学家”两个关键词搜索的文章,这些关键词的年份从1969年到2023年2月不等。这种系统的方法总共产生了2736篇文章;我们的论文中包括了24篇。使用Cochrane偏差风险工具和美国国立卫生研究院工具进行这些文章的偏差风险。
    结果:通过我们系统的文献检索,超过3,577例患者接受了30名介入疼痛管理医师的治疗.暴露于辐射的一些区域包括医生的脖子,胸部,腹股沟,手,和眼睛。暴露于辐射的一个常见的身体区域是胸部;我们的审查发现,佩戴铅围裙可以将辐射剂量降低95%以上。佩戴防护设备和管理操作员与荧光镜之间的距离都可以独立地将辐射剂量降低90%以上。我们的文献综述还发现,在辐射暴露方面经常被忽视的其他身体部位是眼睛和手。在我们的研究中,胸部外部(无保护)的辐射剂量范围从0.008±27mrem到1345mrem,外颈部从572mrem到2,032mrem,腹股沟外侧范围从176mrem到1292mrem,手的范围从0.006±27.4mrem到0.114±269mrem,眼睛范围从40mrem到369mrem。当防护装备被穿戴时,胸部内部的辐射暴露范围从0mrem到108mrem,颈内范围从0mrem到68mrem,腹股沟内侧范围从0mrem到15mrem。
    结论:本研究的局限性包括样本量小;仅对30名介入疼痛管理医师的辐射暴露进行了检查。此外,本综述主要由观察性研究而非随机临床试验组成.
    结论:实施安全预防措施,比如穿戴防护装备,提供教育项目,保持安全距离,证明了辐射暴露的显着减少。介入疼痛管理医生的经验也考虑了他们在手术过程中的辐射暴露。辐射是一种已知的致癌物质,需要更多的研究来更好地了解其对介入疼痛管理医生的风险。
    BACKGROUND: Millions of interventional pain procedures are performed each year to address chronic pain. The increase in these procedures also raises the concern of health risks associated with ionizing radiation for interventional pain management physicians who perform fluoroscopy-guided operations. Some health concerns include cancers, cataracts, and even pregnancy abnormalities. Little is known regarding the long-term and cumulative effects of small radiation doses.
    OBJECTIVE: The objective of this systematic review was to identify common body parts that are exposed to ionizing radiation during interventional pain procedures and examine methods to help physicians reduce their radiation exposure.
    METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) checklist was used to comprehensively identify articles from 2 medical databases. The radiation dose to interventional pain management physicians obtained from relevant peer-reviewed articles were aggregated and used for analysis.
    METHODS: PubMed was first used to collect the articles for two broad keyword searches of \"radiation exposure pain management\" and \"radiation exposure interventionalist\" with years ranging from 1956 - February 2023. EMBASE was also used to collect the articles for the two keyword searches of \"radiation exposure pain management\" and \"radiation exposure interventionalist\" with years ranging from 1969 - February 2023. This systematic approach yielded a total of 2,736 articles; 24 were included in our paper. The risk of bias for these articles was performed using the Cochrane Risk of Bias tool and the National Institutes of Health tool.
    RESULTS: Through our systematic literature search, more than 3,577 patients were treated by 30 interventional pain management physicians. Some areas of exposure to radiation include the physician\'s neck, chest, groin, hands, and eyes. One common body region that is exposed to radiation is the chest; our review found that wearing lead aprons can lower the radiation dose by more than 95%. Wearing protective equipment and managing the distance between the operator and fluoroscope can both independently lower the radiation dose by more than 90% as well. Our literature review also found that other body parts that are often overlooked in regard to radiation exposure are the eyes and hands. In our study, the radiation dose to the outside (unprotected) chest ranged from 0.008 ± 27 mrem to 1,345 mrem, the outside neck ranged from 572 mrem to 2,032 mrem, the outside groin ranged from 176 mrem to 1,292 mrem, the hands ranged from 0.006 ± 27.4 mrem to 0.114 ± 269 mrem, and the eyes ranged from 40 mrem to 369 mrem. When protective equipment was worn, the radiation exposure to the inside chest ranged from 0 mrem to 108 mrem, the inside neck ranged from 0 mrem to 68 mrem, and the inside groin ranged from 0 mrem to 15 mrem.
    CONCLUSIONS: Limitations of this study include its small sample size; only the radiation exposure of 30 interventional pain management physicians were examined. Furthermore, this review mainly consisted of observational studies rather than randomized clinical trials.
    CONCLUSIONS:   Implementing safety precautions, such as wearing protective gear, providing educational programs, and keeping a safe distance, demonstrated a significant decrease in radiation exposure. The experience of interventional pain management physicians also factored into their radiation exposure during procedures. Radiation is a known carcinogen, and more research is needed to better understand its risk to interventional pain management physicians.
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  • 文章类型: Journal Article
    太空中的宇航员经常受到电离辐射的影响。人们担心宇航员长期暴露于太空辐射环境后可能会对健康造成严重和迟发性的不利影响。因此,考虑目前用于描述和研究电离辐射暴露的有机后果的工具和模型是至关重要的。同样重要的是,看看这些模型可以在哪里改进。历史上,放射生物学模型集中于辐射如何损伤核脱氧核糖核酸(DNA)和DNA修复机制在由此产生的生物效应中的作用,建立在1940年代和1960年代Crowther和Lea的假设基础上,他们忽略了核DNA以外的其他亚细胞靶标。这些模型的发展和目前有关辐射效应影响轨道上宇航员的知识状况,以及辐射环境和细胞微环境如何纳入这些放射生物学模型,帮助我们了解太空旅行可能对宇航员健康的影响。至关重要的是,要考虑用于描述电离辐射暴露的有机后果的当前工具和模型,并确定可以进一步改进的地方。
    Astronauts in space are subject to continuous exposure to ionizing radiation. There is concern about the acute and late-occurring adverse health effects that astronauts could incur following a protracted exposure to the space radiation environment. Therefore, it is vital to consider the current tools and models used to describe and study the organic consequences of ionizing radiation exposure. It is equally important to see where these models could be improved. Historically, radiobiological models focused on how radiation damages nuclear deoxyribonucleic acid (DNA) and the role DNA repair mechanisms play in resulting biological effects, building on the hypotheses of Crowther and Lea from the 1940s and 1960s, and they neglected other subcellular targets outside of nuclear DNA. The development of these models and the current state of knowledge about radiation effects impacting astronauts in orbit, as well as how the radiation environment and cellular microenvironment are incorporated into these radiobiological models, aid our understanding of the influence space travel may have on astronaut health. It is vital to consider the current tools and models used to describe the organic consequences of ionizing radiation exposure and identify where they can be further improved.
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  • 文章类型: Journal Article
    透视检查一直是介入心脏病学程序的基础成像方法。然而,辐射暴露与恶性肿瘤和多器官疾病的风险增加有关。医疗团队更容易受到X光的照射,据报道,该专业人群中恶性肿瘤的发病率较高。在过去的几年里,X射线暴露量迅速增加,涉及,最重要的是,医疗团队和年轻患者,并迫使替代非荧光成像方法。在心脏电生理学(EP)和起搏中,带有专用导管的3D电解剖标测系统的出现允许实时,心脏解剖和电活动的高密度重建,显著减少透视的使用。此外,心内超声心动图的扩散为运动的心脏结构提供了较高的解剖学分辨率,为更复杂的导管消融程序提供术中指导。这些方法在很大程度上证明了安全性和有效性,允许在大多数心律失常消融中X射线输送显著减少。然而,一些技术问题,以及更高的成本,目前不允许其在EP实验室中传播,并将其使用限制在仅被认为高度复杂且耗时且适用于年轻患者的程序。在这次审查中,我们的目标是更新目前不同EP程序中无氟成像的使用情况,专注于它的优点和缺点。
    Fluoroscopy has always been the cornerstone imaging method of interventional cardiology procedures. However, radiation exposure is linked to an increased risk of malignancies and multiorgan diseases. The medical team is even more exposed to X-rays, and a higher incidence of malignancies was reported in this professional group. In the last years, X-ray exposure has increased rapidly, involving, above all, the medical team and young patients and forcing alternative fluoroless imaging methods. In cardiac electrophysiology (EP) and pacing, the advent of 3D electroanatomic mapping systems with dedicated catheters has allowed real-time, high-density reconstruction of both heart anatomy and electrical activity, significantly reducing the use of fluoroscopy. In addition, the diffusion of intracardiac echocardiography has provided high anatomical resolution of moving cardiac structures, providing intraprocedural guidance for more complex catheter ablation procedures. These methods have largely demonstrated safety and effectiveness, allowing for a dramatic reduction in X-ray delivery in most arrhythmias\' ablations. However, some technical concerns, as well as higher costs, currently do not allow their spread out in EP labs and limit their use to only procedures that are considered highly complex and time-consuming and in young patients. In this review, we aim to update the current employment of fluoroless imaging in different EP procedures, focusing on its strengths and weaknesses.
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  • 文章类型: Review
    背景:辐射安全教育很重要,因为透视检查通常用于诊断和治疗目的。暴露于高水平的电离辐射与癌症和其他不良健康影响的风险增加有关;因此,泌尿科医师和受训者必须接受安全使用辐射的教育。不幸的是,这一组的放射教育和职业安全没有标准化,目前没有审查泌尿科医师在临床环境中的放射安全性的审查研究。这篇综述旨在调查泌尿外科中使用的各种水平的辐射安全教育和实践。
    方法:在Medline和Embase数据库中搜索有关放射知识和随机对照试验的相关出版物,非随机对照研究,并纳入观察性研究。评论,摘要,社论评论,非泌尿外科研究,不完整的文章被排除在外。
    结果:在这些文章中,有16项观察性研究.辐射暴露的频率范围从每周少于一次到大于15次。与铅眼镜和手套相比,使用铅围裙和甲状腺护罩的依从性更高。辐射安全教育很少。辐射暴露风险的辐射安全知识尤其低。大多数研究强调需要提高泌尿科受训人员和顾问对辐射安全的认识和培训。
    结论:辐射安全教育和实践是泌尿外科的一个重要问题。改进教育和遵守辐射安全实践对于确保泌尿科医师和受训者以安全和负责任的方式使用电离辐射至关重要。
    Introduction: Radiation safety education is important as fluoroscopy is commonly used for diagnostic and therapeutic purposes. Exposure to high levels of ionizing radiation is associated with an increased risk of cancer and other adverse health effects; therefore, it is essential that urologists and trainees are educated on the safe use of radiation. Unfortunately, radiation education and occupational safety is not standardized for this group and there are currently no review studies examining radiation safety for urologists in the clinical setting. This review aims at investigating the various levels of radiation safety education and practices used in urology. Methods: MEDLINE and EMBASE databases were searched for relevant publications reporting on radiation knowledge and randomized controlled trials, non-randomized comparative studies, and observational studies were included. Reviews, abstracts, editorial comments, non-urologic studies, and incomplete articles were excluded. Results: Within these articles, there were 16 observational studies. Frequency of radiation exposure ranged from <1 × to >15 × /week. There were higher rates of adherence to use of lead aprons and thyroid shields than lead eyeglasses and gloves. Radiation safety education was infrequent. Radiation safety knowledge was especially low for the risks of radiation exposure. Most studies highlight the need for increased awareness and training on radiation safety for both urology trainees and consultants. Conclusions: Radiation safety education and practices are an important issue in urology. Improvements to education and compliance to radiation safety practices are critical to ensuring urologists and trainees use ionizing radiation in a safe and responsible manner.
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  • 文章类型: Meta-Analysis
    电离辐射是人类致癌物,但低剂量电离辐射(LDIR)会增加心血管不良结局风险的证据尚不清楚.我们综合了长期职业暴露于LDIR和心血管疾病的文献,特别是缺血性心脏病(IHD)。使用三个数据库进行文献检索,包括1990年至2022年之间发表的研究。使用卫生和评估办公室完成了对研究的质量评估,以及偏差评估工具的翻译风险。我们使用随机效应模型对IHD死亡率进行了荟萃分析,该模型使用从内部队列比较中获得的超额相对风险/sievert(ERR/Sv)。以及来自外部队列比较的标准化死亡率(SMR)。我们确定了2189篇文章,其中,26提供了关于IHD的数据并被保留。大多数研究被归类为“中度”偏倚风险水平。使用SMR和ERR/Sv进行荟萃分析的14项和10项报告外部辐射剂量的研究。分别。meta-summarySMR为0.81(95%CI0.74至0.89),有证据表明风险降低,但研究中的异质性高。对于内部队列度量,滞后10年暴露的总ERR/Sv为0.10(95%CI0.01~0.20),异质性较低.通过滞后暴露时间的亚组分析显示,滞后15年和20年的关联最强。我们的研究结果表明,职业暴露于LDIR会增加IHD死亡率的风险,并强调了内部队列比较的相关性。
    Ionising radiation is a human carcinogen, but the evidence is less clear that exposure to low-dose ionising radiation (LDIR) increases the risk of adverse cardiovascular outcomes. We synthesised the literature of chronic occupational exposure to LDIR and cardiovascular disease, particularly for ischaemic heart disease (IHD).The literature search was conducted using three databases including studies published between 1990 and 2022. A quality assessment of the studies was completed using the Office of Health and Assessment and Translation Risk of Bias Rating Tool. We conducted meta-analyses for IHD mortality using random effects models using measures of excess relative risk per sievert (ERR/Sv) obtained from internal cohort comparisons, as well as with standardised mortality ratios (SMRs) from external cohort comparisons.We identified 2189 articles, and of these, 26 provided data on IHD and were retained. Most studies were classified as having a \'moderate\' level of risk of bias. Fourteen and 10 studies reporting external radiation doses were included in meta-analyses using SMR and ERR/Sv, respectively. The meta-summary SMR was 0.81 (95% CI 0.74 to 0.89) with evidence of reduced risk but high heterogeneity across studies. For internal cohort measures, the summary ERR/Sv for a lagged exposure of 10 years was 0.10 (95% CI 0.01 to 0.20) with low heterogeneity. The subgroup analysis by lagged exposure time showed the strongest association were for the 15 and 20 years lag.Our findings suggest that occupational exposure to LDIR increases the risk IHD mortality and highlight the relevance of internal cohort comparisons.
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  • 文章类型: Meta-Analysis
    值得注意的是,越来越多地使用放射性核技术,特别是在涉及辐射暴露的诊断和治疗程序中,引起人们对辐射对健康影响的担忧。尽管流行病学研究提供了强有力的证据,表明儿童接受辐射后患甲状腺癌的风险升高,与成人接触相关的甲状腺癌风险仍有待研究.我们对成年期辐射暴露后患甲状腺癌风险的相关研究进行了系统评价和荟萃分析。PubMed和WebofScience数据库用于选择符合条件的文章。筛选后,共确定了15项研究,其中有8项和11项研究估计了甲状腺癌的标准化发病率(SIR)和相对风险(RR)。分别。随机效应模型估计的总体SIR为2.19[95%置信区间(CI),1.54、3.10]。Cochran的Q检验显示SIR具有显著的异质性(Q=178,P<0.0001)。10mGy时的总RR为1.0038(95%CI,0.9991,1.0085),差异无统计学意义(Q=9.30,P=0.5041)。总SIR,以及每一项研究,表明有统计学意义的超额,这可能与筛查偏倚有关。在一些研究中,辐射相关的甲状腺癌风险升高;然而,RR在10mGy时的总体估计值不显著.这项研究表明,没有强有力的流行病学证据表明,在成年期辐射暴露中甲状腺癌的风险;然而,需要进一步的研究。
    Notably, the growing use of radionuclear technology, especially in diagnostic and therapeutic procedures involving radiation exposure, raises concerns about the health effects of radiation. Although epidemiological studies have provided strong evidence for elevated thyroid cancer risk after radiation exposure in childhood, the risk of thyroid cancer associated with adult exposure remains to be investigated. We conducted a systematic review and meta-analysis of relevant studies on the risk of developing thyroid cancer after radiation exposure in adulthood. The PubMed and Web of Science databases were used to select eligible articles. After screening, a total of 15 studies were identified in which estimates of the standardized incidence ratio (SIR) and the relative risk (RR) of thyroid cancer were available in 8 and 11 studies, respectively. The overall SIR estimated by the random effects model was 2.19 [95% confidence interval (CI), 1.54, 3.10]. Cochran\'s Q test showed significant heterogeneity in the SIRs (Q = 178, P < 0.0001). The overall RR at 10 mGy was 1.0038 (95% CI, 0.9991, 1.0085), with no significant heterogeneity (Q = 9.30, P = 0.5041). The total SIR, as well as that from each study, indicated a statistically significant excess, which could be related to screening bias. Radiation-related thyroid cancer risk was elevated in a few studies; however, the overall estimate of the RR at 10 mGy was not significant. This study demonstrates no strong epidemiological evidence for the risk of thyroid cancer in radiation exposure during adulthood; however, further research is needed.
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